University of South Florida Application for Improving Animal Resources

描述（由申请人提供）：支持要求在大学的老鼠屏障设施位于新的稳定的研究大楼（SRB）的大学附属H急需的移动设备。李莫菲特癌症中心和研究所于2005年2月被占领。自1996年以来，动物护理和使用服务需求增加了803%，主要是由于基因工程小鼠数量增加了1183%。该集中管理的AAALAC认证项目的现有动物设施的容量 在坦帕湾，所有的研究都超过了标准，而且都缺乏安全的微生物屏障，使研究面临因感染性暴露而无效的风险。SRB小鼠屏障设施位于联邦资助的小鼠研究的最大焦点附近，毗邻坦帕湾历史上最大的研究实验室扩建。该机构建立了6，231 nsf的额外小鼠饲养空间，小鼠模型核心的专用实验室，小鼠病理学核心的专用尸检，以及体内小鼠成像核心的一套实验室，所有这些都在严格的微生物安全环境中。需要超过17，640个微型隔离器来容纳多达70，560只小鼠。需要支持购买11%所需的小鼠微隔离器，或16个单独通风的小鼠微隔离器架，8个相关的空气处理器，140个额外的笼子设置和5个运输架。所申请的可移动设备的净效益将用于由使用这一区域资源的八个附属机构的科学家指导的国家认可的生命科学研究。

DESCRIPTION (provided by applicant): Support is requested for movable equipment critically needed in the University's Mouse Barrier Facility located in the new Stabile Research Building (SRB) of the University-affiliated H. Lee Moffitt Cancer Center and Research Institute occupied in February 2005. This facility was established in response to an 803% increase in animal care and use service demands since 1996, due principally to an 1183% increase in the number of genetically engineered mice. Capacities of existing animal facilities of this centrally administered, AAALAC accredited program in Tampa Bay had been exceeded, and all lacked a secure microbiological barrier, placing studies at risk of being invalidated due to infectious exposures. The SRB Mouse Barrier Facility is ideally located near the greatest focus of federally funded research involving mice, and adjacent to the largest research laboratory expansion in Tampa Bay history. The facility established 6,231 nsf of additional mouse housing space, a dedicated laboratory for the Mouse Models Core, a dedicated necropsy for the Mouse Pathology Core, and a suite of laboratories for the In Vivo Mouse Imaging Core, all in a setting of stringent microbiological security. More than 17,640 microisolators are needed to house up to 70,560 mice. Support is requested to purchase 11% of the needed mouse microisolators, or 16 individually ventilated mouse microisolator racks, 8 associated air handlers, 140 additional cage setups and 5 transport racks. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight affiliated institutions that use this regional resource.