Tissue Core-UNMC Rapid Autopsy Program

组织核心-UNMC快速尸检项目

• 批准号: 10707538
• 负责人: Paul M Grandgenett
• 金额: $ 9.66万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707538
• 关键词: Acute; Adrenal Glands; Archives; Ascites; Autopsy; Benign; Biological; Biopsy; Cancer Center; Cell Culture Techniques; Cell Line; Chronic; Clinical; Clinical Data; Clinical Trials; Collaborations; Collection; Core Facility; DNA; Database Management Systems; Dedications; Diagnostic; Diagnostic Procedure; Disease; Disease Resistance; Disease model; Duodenum; Eligibility Determination; Ensure; Fibrosis; Fresh Tissue; Goals; Growth; Histologic; Human; Informed Consent; Intercellular Fluid; Large Intestine; Liquid substance; Liver; Lung; Lymphocyte; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of pancreas; Medical center; Modeling; Muscle; Nebraska; Neoplasm Metastasis; Neuroendocrine Tumors; Oncology; Operative Surgical Procedures; Organ; Organ Procurements; Organoids; Pancreas; Pancreatic Ductal Adenocarcinoma; Pancreatic carcinoma; Pancreatitis; Patient Care; Patient Monitoring; Patients; Peripheral Blood Lymphocyte; Plasma; Procedures; Quality Control; Recording of previous events; Reproducibility; Research; Research Activity; Research Personnel; Resistance; Resources; Respiratory Diaphragm; Risk; Sampling; Scientist; Sequence Analysis; Serum; Small Intestines; Specimen; Spleen; System; Tissue Banks; Tissues; Translational Research; Universities; Writing; Xenograft procedure; biobank; lymph nodes; multidisciplinary; neoplastic; novel; peripheral blood; programs; repository; research study; resistance mechanism; sample archive; therapy resistant

Project Summary Abstract All projects in this ARTNet application will use deidentified human specimens for research directed at understanding acquired resistance to therapy in pancreatic ductal adenocarcinoma. In order to provide the necessary specimens, a Tissue Core has been developed in cooperation with and under the auspices of the University of Nebraska Medical Center (UNMC) Tissue Bank, with the goal of providing a coordinated and centralized core dedicated to procuring, processing and distributing biological specimens and associated de- identified clinical data. The Rapid Autopsy Program (RAP) core facility stores normal, benign (i.e. acute and/or chronic fibrosing pancreatitis) and malignant pancreatic tissues (including both primary and metastatic pancreatic carcinomas as well as neuroendocrine tumors) and peripheral blood lymphocytes, plasma and serum from patients undergoing surgical procedures for pancreatic malignancies and from deceased patients with a history of pancreatic cancer (rapid autopsy). Non-cancer donor whole pancreata, spleen, duodenum, liver, lung, muscle, lymph node and adrenal tissue are also collected in collaboration with local organ procurement agencies. The RAP biorepository also coordinates with surgery and oncology, as well as several well-established UNMC patient monitoring programs, such as the PCDC and PCCR, to develop robust longitudinal collections of pre, early, and end-stage tissue and biofluid sample sets. Importantly, the currently archived samples available from the rapid autopsy program are a UNMC-based resource representing the exact sample sets necessary to investigate acquired resistance in PDAC disease and continued growth of the resource will only serve to enhance UNMC’s ability to study disease resistance. The core also maintains a cache of various resources available to all cancer investigators, such as disease and normal TMAs, donor sample sequence analysis and fresh tissue acquisition. The bank includes a mechanism for database management and specimen distribution (Freezerworks) and a uniform system of prioritization of requested materials has been defined and used by the Tissue Bank Oversight Committee. This core facility is intended to benefit the specific research activities of the ARTNet, as well as the research activities of other scientists within and outside of UNMC who are concentrating on translational research issues and resistance mechanisms. Only specimens obtained from clinically indicated surgeries after all other diagnostic procedures have been performed will be submitted to the UNMC ARTNet tissue bank for resistance research. The specimens would otherwise be discarded or disposed. Eligible patients have the opportunity to participate by submitting written informed consent. There is no risk to the patient or compromise to the patient's care, as all the procedures performed would be performed for diagnostics regardless of the collection need. .

项目摘要 在此应用中的所有项目将使用去识别的人类标本进行研究， 了解胰腺导管腺癌的获得性耐药。为了提供 必要的标本，一个组织核心已经开发合作，并在主持下， 内布拉斯加大学医学中心（UNMC）组织库，目标是提供一个协调和 集中式核心，专门用于采购、处理和分发生物标本以及相关的去 识别的临床数据。快速尸检程序（RAP）核心设施储存正常、良性（即急性） 和/或慢性纤维化胰腺炎）和恶性胰腺组织（包括原发性和转移性 胰腺癌以及神经内分泌肿瘤）和外周血淋巴细胞、血浆和 来自进行胰腺恶性肿瘤外科手术的患者和来自死亡患者的血清 有胰腺癌病史的患者（快速尸检）。非癌症捐赠者全胰腺，脾脏， 十二指肠、肝、肺、肌肉、淋巴结和肾上腺组织也与当地的 器官采购机构RAP生物储存库还与外科和肿瘤学以及 几个完善的联合国医务委员会病人监测计划，如PCDC和PCCR，以发展 对前期、早期和末期组织和生物流体样本集进行稳健的纵向收集。重要的是 目前，快速尸检项目提供的存档样本是联合国军事委员会的资源 代表研究PDAC疾病获得性耐药性所需的确切样本集， 资源的持续增长只会有助于提高联合国监测委员会研究抗病能力的能力。的 核心还维护了所有癌症研究人员可用的各种资源的缓存，例如疾病和 正常TMA、供体样品序列分析和新鲜组织采集。该银行包括一个 数据库管理和标本分发机制（Freezerworks）和统一的 组织库监督委员会已确定并使用所需材料的优先级。 该核心设施旨在使ARTNet的具体研究活动以及研究受益 联合国海洋学委员会内外专注于转化研究的其他科学家的活动 问题和阻力机制。 只有从所有其他诊断程序后的临床手术中获得的标本才具有 将提交给联合国MC ARTNet组织库进行耐药性研究。的 否则将丢弃或处置样本。符合条件的患者有机会参加 提交书面知情同意书。不会对患者造成风险或影响患者的护理， 因为所执行的所有过程都将被执行用于诊断而不管收集需要如何。 .