Unique epigenetic states in plant stem cell niches for safeguarding genome integrity

植物干细胞生态位中独特的表观遗传状态可保护基因组完整性

• 批准号: DP140104044
• 负责人: Prof Ryan Lister
• 金额: $ 27.64万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104044
• 关键词: Unique; epigenetic; states; plant; stem

Plant stem cells are the foundation cells of all plant growth and development, including generation of the reproductive cells. Therefore, it is critical that stem cells defend against attacks that may damage the genome. A unique epigenetic state in plant stem cell niches has been discovered that may protect the genome from damage due to parasitic DNA elements. Using sophisticated genomics, genetics, and cellular technologies, this project will investigate how stem cell epigenetic state is linked to genome defence, how environmental stresses can disrupt the defence system, and the role of the system in driving new genetic diversity. This knowledge is of high importance as agricultural crops enter an era of increasingly challenging conditions.

植物干细胞是所有植物生长发育的基础细胞，包括生殖细胞的产生。因此，干细胞防御可能损害基因组的攻击至关重要。在植物干细胞小生境中发现了一种独特的表观遗传状态，它可以保护基因组免受寄生DNA元件的损害。利用复杂的基因组学，遗传学和细胞技术，该项目将研究干细胞表观遗传状态如何与基因组防御相关联，环境压力如何破坏防御系统，以及该系统在驱动新的遗传多样性中的作用。随着农业作物进入一个条件日益严峻的时代，这一知识具有高度重要性。