FUNCTIONAL NEUROANATOMY OF THE BASOLATERAL AMYGDALA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在本报告所述期间，我们绘制了大鼠和灵长类动物基底外侧杏仁核中定义的子区域神经元的生理特性。 此外，我们还研究了抑制性突触电位引起投射神经元放电同步化的细胞机制。 我们的数据表明，自发IPSPs相互作用的内在膜振荡是目前在膜电位接近阈值的动作电位产生。 我们有证据表明，三个内在的膜电流有助于振荡，这些电流可以积极修改的神经递质，通过G蛋白G-蛋白第二信使级联耦合。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period we mapped the physiological properties of neurons in defined sub-regions of the rat and primate basolateral amygdala. In addition, we worked to determine the cellular mechanisms underlying the synchronization of projection neuron firing by inhibitory synaptic potentials. Our data suggests that spontaneous IPSPs interact with an intrinsic membrane oscillation that is present at membrane potentials close to threshold for action potential generation. We have evidence that three intrinsic membrane currents contribute to the oscillation and that these currents can be positively modified neurotransmitters that couple through the Gs G-protein second messenger cascade.