FUNCTIONAL NEUROANATOMY OF THE BASOLATERAL AMYGDALA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在报告期间，我们绘制了大鼠和灵长类杏仁基底外侧核特定亚区神经元的生理特性图。此外，我们致力于通过抑制性突触电位来确定投射神经元放电同步的细胞机制。我们的数据表明，自发的IPSP与固有的膜振荡相互作用，这种振荡存在于接近动作电位产生阈值的膜电位上。我们有证据表明，三个固有的膜电流参与了振荡，并且这些电流可以是正向修饰的神经递质，通过Gs G蛋白第二信使级联耦合。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period we mapped the physiological properties of neurons in defined sub-regions of the rat and primate basolateral amygdala. In addition, we worked to determine the cellular mechanisms underlying the synchronization of projection neuron firing by inhibitory synaptic potentials. Our data suggests that spontaneous IPSPs interact with an intrinsic membrane oscillation that is present at membrane potentials close to threshold for action potential generation. We have evidence that three intrinsic membrane currents contribute to the oscillation and that these currents can be positively modified neurotransmitters that couple through the Gs G-protein second messenger cascade.