FUNCTIONAL NEUROANATOMY OF THE BASOLATERAL AMYGDALA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定杏仁核基底外侧投射神经元的固有膜和局部网络特性，这些特性有助于杏仁核基底外侧投射神经元的整体振荡活动。我们开始绘制大鼠和灵长类杏仁基底外侧核特定亚区神经元的生理特性图。虽然BLA中间神经元是一个异质的细胞群，但传统上该区域的投射神经元被聚集在一起作为一个同源单位。我们收集了来自大鼠和灵长类动物的数据，这些数据直接与BLA投射神经元功能特性的同质性概念相矛盾。我们正在使用多因子分析和K-均值聚类分析来梳理BLA投射神经元的不同亚群。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this study are to identify intrinsic membrane, and local network properties that contribute to oscillatory activity in ensembles of basolateral amygdala projection neurons. We began to map the physiological properties of neurons in defined sub-regions of the rat and primate basolateral amygdala. While BLA interneurons are known to be a heterogeneous cell population, traditionally projection neurons in this region have been lumped together as a homologous unit. We have collected data from both the rat and primate that directly contradicts the notion of homogeneity in the functional properties of BLA projections neurons. We are using multiple factorial analyses in conjunction with K-means cluster analysis to tease apart distinct subpopulations of BLA projection neurons.