Component III: Stress Related College Drinking: Learned and Genetic Vulnerabiliti

第三部分：与压力相关的大学饮酒：习得性和遗传性脆弱性

• 批准号: 7499828
• 负责人: HOWARD TENNEN
• 金额: $ 25.34万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-03-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499828
• 关键词: Address; Affect; Affective; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Alleles; Behavioral Genetics; Belief; Buffers; Candidate Disease Gene; Carrier Proteins; DNA; Daily; Data; Data Collection; Dependence; Development; Disease susceptibility; Early identification; Emotional; Environment; Etiology; Event; Expectancy; Family; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genotype; Goals; Grant; Individual; Intake; Internet; Intervention; Investigation; Learning; Life; Link; Measures; Mediating; Memory; Modeling; Motivation; Neurotransmitters; Numbers; Outcome; Participant; Pathway interactions; Pattern; Persons; Phenotype; Play; Population; Prevention; Preventive; Process; Publishing; Reporting; Research; Risk; Risk Factors; Role; Saliva; Serotonin; Social support; Source; Stress; Stressful Event; Students; Surveys; Symptoms; System; Techniques; Testing; Time; Variant; alcohol effect; alcohol use disorder; base; college drinking; coping; day; drinking; drinking behavior; experience; genetic risk factor; innovation; interest; neurotransmission; response; serotonergic regulation; serotonin transporter; social; social cognitive theory; stressor; university student

Component III - Stress-Related College Drinking: Learned and Genetic Vulnerabilities The proposed study will examine simultaneously the roles of learned and genetic risk factors for college student drinking in response to stress- and affect-related triggers. Specifically, we will evaluate how sociallylearned vulnerabilities, such as beliefs and motivations regarding the calming effects of drinking, as well as genetic vulnerabilities, including genes related to serotonin function, serve as diatheses for engaging in stress- and negative affect-related drinking (SNAD). Our proposed study will model SNAD processes at two levels. At the MACRO-LEVEL, we will examine how learned and genetic vulnerabilities interplay with major life stressors (i.e., early family environment, traumatic encounters, and negative life events) to influence average drinking outcomes and abuse/dependent symptoms among college students. At the MICROLEVEL, we will examine how learned and genetic vulnerabilities interplay with daily stressors and negative affect states to influence drinking, alcohol abuse/dependence symptoms, and coping-related drinking on a day-to-day basis among college students. To address these aims, we will employ an innovative Internet reporting system to (a) administer one-time measures of social learning risk factors, major life stressors, and average alcohol abuse/dependence symptoms and (b) track daily stress, affect, and alcohol use during a 30- day period among 1600 college students. This close to real-time data collection technique will minimize memory biases, thereby providing robust and reliable reports of daily alcohol use and related experiences. Saliva will be collected and DNA isolated and genotyped for carefully selected candidate genes, including the serotonin transporter gene-linked polymorphism (5-HTTLPR) and other genes identified as potentially important risk factors for engaging in stress-related drinking. The proposed study is the first to examine how social learning and genetic vulnerabilities together contribute to both drinking levels in response to major life stressors and day-to-day drinking patterns in response to proximal daily stressors. This project will provide greater understanding of the factors that engender maladaptive drinking behaviors in a college-student population, which will potentially inform preventive and treatment interv

组件III-与压力相关的大学饮酒：学习和遗传脆弱性 拟议的研究将同时检查学到的大学和遗传风险因素的作用 学生饮酒是为了应对压力和影响相关的触发因素。具体而言，我们将评估社会学的方式 脆弱性，例如关于饮酒的平静作用的信念和动机，以及 遗传脆弱性，包括与5-羟色胺功能有关的基因，是参与 应力和负面影响相关的饮酒（SNAD）。我们提出的研究将模拟SNAD过程的两个 水平。在宏观层面上，我们将研究学习和遗传脆弱性与主要的相互作用 生活压力源（即早期家庭环境，创伤性遭遇和负面生活事件）影响 大学生的平均饮酒结果和滥用/依赖症状。在mictovel， 我们将研究学习和遗传脆弱性如何与日常压力源相互作用和负面 影响国家影响饮酒，酗酒/依赖症状以及与饮酒有关 大学生的日常基础。为了解决这些目标，我们将采用创新的互联网 报告系统向（a）管理社会学习风险因素，主要生活压力和 平均酒精滥用/依赖性症状以及（b）30-期间的日常压力，影响和饮酒 1600名大学生的日期。这种接近实时数据收集技术将最小化 记忆偏见，从而提供每日酒精饮酒和相关经验的强大而可靠的报告。 将收集唾液，并分离出DNA，并分离出基因分型，以精心选择的候选基因，包括 5-羟色胺转运蛋白基因连锁多态性（5-HTTLPR）和其他被鉴定为潜在的基因 参与与压力有关的饮酒的重要风险因素。拟议的研究是第一个研究如何 社会学习和遗传脆弱性共同有助于两种饮酒水平，以响应主要生活 压力源和日常饮酒方式，以响应近端压力源。这个项目将提供 对大学生中导致不良适应饮酒行为的因素有更深入的了解 人口，可能会为预防和治疗间隔提供信息