ES CELL TRANSPLANTATION AND PARKINSON?S DISEASE

ES 细胞移植与帕金森病

• 批准号: 7716400
• 负责人: Ei Terasawa-Grilley
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716400
• 关键词: Animals; Brain; Cell Transplantation; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Control Animal; Corpus striatum structure; Funding; Grant; Health Services Research; Human; Injection of therapeutic agent; Institution; Macaca mulatta; Operative Surgical Procedures; Parkinson Disease; Parkinsonian Disorders; Research; Research Personnel; Resources; Services; Source; Stem cell transplant; Substantia nigra structure; Symptoms; Testing; Transplantation; United States National Institutes of Health; dopaminergic neuron; embryonic stem cell; human embryonic stem cell; nonhuman primate; precursor cell; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test the hypothesis that neural precursor cells differentiated from embryonic stem cells and transplanted into the brain alleviates Parkinsonian symptoms in nonhuman primates. Hemi-parkinsonian symptoms were induced by MPTP injection. Neural precursor cells differentiated from human or rhesus embryonic stem cells were transplanted into the striatum and substantia nigra. Sham control animals received the same surgery, but no neural precursor cells. Results suggested that transplantation of neural precursor cells survived for up to 5 months, transformed into dopamine neurons, and alleviated Parkinsonian symptoms. These preliminary observations show potential use of embryonic stem cells for human clinical treatments. This research used Animal Services and Research Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 测试神经前体细胞从胚胎干细胞分化并移植到大脑中可以减轻非人类灵长类动物的帕金森症状的假设。 MPTP 注射诱发偏侧帕金森病症状。由人类或恒河猴胚胎干细胞分化而来的神经前体细胞被移植到纹状体和黑质中。假手术对照动物接受相同的手术，但没有神经前体细胞。结果表明，移植的神经前体细胞存活长达5个月，转化为多巴胺神经元，并缓解了帕金森症状。这些初步观察结果表明胚胎干细胞在人类临床治疗中的潜在用途。这项研究使用了动物服务和研究服务。