THE EFFECT OF ANOREXIA NERVOSA ON PEAK BONE MASS

神经性厌食症对峰值骨量的影响

• 批准号: 7731313
• 负责人: ANNE KLIBANSKI
• 金额: $ 0.83万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731313
• 关键词: Adolescence; Adult; Age; Anorexia Nervosa; Chronic Disease; Complication; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; Disease; Dose; Double-Blind Method; Eating Disorders; Estrogens; Female Adolescents; Funding; Grant; Institution; Metabolism; Minerals; Placebo Control; Population; Prevalence; Randomized; Recovery; Research; Research Personnel; Resources; Source; Therapeutic; United States National Institutes of Health; Woman; bone; girls; improved; pill

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa (AN) is the third most common chronic illness among adolescent girls, with a prevalence of 0.2-1%. Osteopenia is a major co-morbid complication of anorexia nervosa both in female adolescents and in adult women with this eating disorder. Improved understanding of bone mineral metabolism and of factors that predict recovery of bone mineral accretion is critical to develop therapeutic strategies to maximize bone mass in girls with onset of AN in adolescence. Although profound estrogen deficiency is seen in AN, no controlled studies have investigated the effects of estrogen administration on this population. In this randomized, placebo controlled, double blinded study, we plan to examine the effects of administration of estrogen as a low dose pill (in adolescent girls with AN, bone age 13.5-15 years) or as a transdermal patch (in girls with bone age > 15 years) for 1 and 1/2 years on bone mass in adolescent girls with this disorder.

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