THE EFFECT OF ANOREXIA NERVOSA ON PEAK BONE MASS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 神经性厌食症（AN）是青春期女孩中第三常见的慢性疾病，患病率为0.2- 1%。 骨质减少是一个主要的并发症，神经性厌食症，无论是在女性青少年和成年妇女与这种饮食失调。 提高对骨矿物质代谢和预测骨矿物质增加恢复的因素的理解对于制定治疗策略以最大化青春期AN发作女孩的骨量至关重要。虽然在AN中发现了严重的雌激素缺乏，但没有对照研究调查雌激素给药对这一人群的影响。 在这项随机、安慰剂对照、双盲研究中，我们计划检查雌激素作为低剂量药丸（在患有AN的青春期女孩中，骨龄13.5-15岁）或作为透皮贴剂（在骨龄> 15岁的女孩中）给药1年和1/2年对患有这种疾病的青春期女孩骨量的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa (AN) is the third most common chronic illness among adolescent girls, with a prevalence of 0.2-1%. Osteopenia is a major co-morbid complication of anorexia nervosa both in female adolescents and in adult women with this eating disorder. Improved understanding of bone mineral metabolism and of factors that predict recovery of bone mineral accretion is critical to develop therapeutic strategies to maximize bone mass in girls with onset of AN in adolescence. Although profound estrogen deficiency is seen in AN, no controlled studies have investigated the effects of estrogen administration on this population. In this randomized, placebo controlled, double blinded study, we plan to examine the effects of administration of estrogen as a low dose pill (in adolescent girls with AN, bone age 13.5-15 years) or as a transdermal patch (in girls with bone age > 15 years) for 1 and 1/2 years on bone mass in adolescent girls with this disorder.