THE EFFECT OF ANOREXIA NERVOSA ON PEAK BONE MASS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经性厌食症(AN)是青春期女孩中第三常见的慢性病，患病率为0.2-1%。骨量减少是神经性厌食症的主要并发症，在女性青少年和患有这种饮食障碍的成年女性中都是如此。更好地了解骨矿物质代谢和预测骨矿物质积累恢复的因素，对于制定治疗策略，最大限度地增加青春期AN女孩的骨量至关重要。尽管在AN中发现严重的雌激素缺乏，但没有对照研究调查雌激素对这一人群的影响。在这项随机、安慰剂对照的双盲研究中，我们计划检测雌激素作为低剂量药片(在患有骨龄13.5-15岁的青春期女孩中)或作为透皮贴片(在骨龄为15岁的女孩中)持续1年和1年半对患有这种疾病的青春期女孩的骨量的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa (AN) is the third most common chronic illness among adolescent girls, with a prevalence of 0.2-1%. Osteopenia is a major co-morbid complication of anorexia nervosa both in female adolescents and in adult women with this eating disorder. Improved understanding of bone mineral metabolism and of factors that predict recovery of bone mineral accretion is critical to develop therapeutic strategies to maximize bone mass in girls with onset of AN in adolescence. Although profound estrogen deficiency is seen in AN, no controlled studies have investigated the effects of estrogen administration on this population. In this randomized, placebo controlled, double blinded study, we plan to examine the effects of administration of estrogen as a low dose pill (in adolescent girls with AN, bone age 13.5-15 years) or as a transdermal patch (in girls with bone age > 15 years) for 1 and 1/2 years on bone mass in adolescent girls with this disorder.