NEUROENDOCRINE FACTORS IN ADOLESCENT OBESITY

青少年肥胖的神经内分泌因素

• 批准号: 7731256
• 负责人: ANNE KLIBANSKI
• 金额: $ 0.05万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731256
• 关键词: Adolescent; Age; Body Composition; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Development; Employee Strikes; Epidemic; Female Adolescents; Funding; Grant; Hormones; Institution; Insulin; Insulin Resistance; Neurosecretory Systems; Obesity; Overweight; Pattern; Research; Research Personnel; Resources; Somatotropin; Source; Stomach; United States National Institutes of Health; Weight; age group; ghrelin; increased appetite

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH), and insulin, which have not been examined in the adolescent age group. Ghrelin, a hormone produced mainly in the stomach, increases appetite and causes GH secretion. This study will compare the change in secretion of ghrelin and GH in overweight and normal weight adolescent girls. Understanding obesity-related changes in ghrelin and GH and their relationship to body composition, insulin resistance, and appetite will help in the development of strategies to reduce complications of obesity.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肥胖是一种流行病，它比以往任何时候都更年轻。 肥胖与几种激素的分泌模式的变化有关，包括生长素素，生长激素（GH）和胰岛素，这些激素尚未在青少年年龄组中进行检查。 Ghrelin是一种主要在胃中产生的激素，可增加食欲并引起GH分泌。 这项研究将比较超重和正常体重青春期女孩中Ghrelin和GH的分泌变化。 了解与肥胖相关的变化蛋白和GH的变化及其与身体成分，胰岛素抵抗和食欲的关系将有助于制定减少肥胖并发症的策略。