CLINICAL TRIAL: EFFECTS OF SUPRAPHYSIOLOGICAL RHGH ON BONE METABOLISM IN ANOREXI

临床试验：超生理学 RHGH 对厌食症患者骨代谢的影响

• 批准号: 7731266
• 负责人: ANNE KLIBANSKI
• 金额: $ 0.37万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731266
• 关键词: Anorexia Nervosa; Blinded; Body Composition; Bone Density; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Osteogenesis; Patients; Placebo Control; Randomized; Research; Research Personnel; Resistance; Resources; Source; United States National Institutes of Health; bone; bone metabolism; bone turnover; r-hGH-M

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia Nervosa (AN) is associated with a low bone mineral density (BMD). Studies suggest a nutritionally acquired resistance to GH, a bone anabolic factor, in AN. We hypothesize that supraphysiological rhGH in patients with AN will overcome the GH resistance, and cause subsequent beneficial effects on bone formation. 22 subjects will be single blinded, randomized & placebo controlled, while evaluating the effects of rhGH over 3 months. Bone turnover markers, body composition & BMD will be evaluated in this study.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 神经性厌食症（AN）与低骨矿物质密度（BMD）有关。研究表明AN患者存在对生长激素（一种骨合成代谢因子）的营养获得性抵抗。我们推测，超生理rhGH在AN患者将克服GH抵抗，并导致随后的骨形成的有益影响。22名受试者将是单盲、随机化和安慰剂对照的，同时评估rhGH在3个月内的效果。本研究将评估骨转换标志物、身体成分和BMD。