CLINICAL TRIAL: THE EFFECTS OF TESTOSTERONE AND ACTONEL ON BONE DENSITY IN ANORE

临床试验：睾酮和 Actonel 对肛门骨密度的影响

• 批准号: 7731240
• 负责人: ANNE KLIBANSKI
• 金额: $ 2.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731240
• 关键词: Adrenal Glands; Anorexia Nervosa; Bone Density; Cells; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Eating Disorders; Fracture; Funding; Grant; Hormones; Institution; Maintenance; Muscle; Osteoblasts; Osteogenesis; Osteoporosis; Osteoporosis prevention; Ovary; Pharmaceutical Preparations; Physiological; Postmenopause; Purpose; Research; Research Personnel; Resources; Risedronate; Source; Testosterone; United States National Institutes of Health; Woman; bone; men; risedronate sodium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa is an eating disorder that can cause thinning of the bones (a decrease in bone density). A significant decrease in bone density is called osteopenia or osteoporosis. Sometimes the loss of bone density can be severe enough to cause breaks and fractures of the bones. It is not known what causes the bones to thin in anorexia nervosa. The purpose of the study is to evaluate the effects of two different medications, physiologic testosterone replacement and risedronate, on bone density in subjects with anorexia nervosa. Testosterone is a hormone that is made by the ovaries and adrenal glands in both women and men and has been shown to be important for prevention of osteoporosis and maintenance of muscle mass in men. Testosterone has been shown to stimulate bone forming cells called osteoblasts, and to increase bone formation and bone density in post-menopausal women, but its effects on bone formation or bone density in women with anorexia nervosa are not known. Actonel is a medication that is prescribed for low bone density to postmenopausal women.

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