CLINICAL TRIAL: THE EFFECTS OF TESTOSTERONE AND ACTONEL ON BONE DENSITY IN ANORE
临床试验:睾酮和 Actonel 对肛门骨密度的影响
基本信息
- 批准号:7731240
- 负责人:
- 金额:$ 2.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-01 至 2008-05-31
- 项目状态:已结题
- 来源:
- 关键词:Adrenal GlandsAnorexia NervosaBone DensityCellsClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseEating DisordersFractureFundingGrantHormonesInstitutionMaintenanceMuscleOsteoblastsOsteogenesisOsteoporosisOsteoporosis preventionOvaryPharmaceutical PreparationsPhysiologicalPostmenopausePurposeResearchResearch PersonnelResourcesRisedronateSourceTestosteroneUnited States National Institutes of HealthWomanbonemenrisedronate sodium
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Anorexia nervosa is an eating disorder that can cause thinning of the bones (a decrease in bone density). A significant decrease in bone density is called osteopenia or osteoporosis. Sometimes the loss of bone density can be severe enough to cause breaks and fractures of the bones. It is not known what causes the bones to thin in anorexia nervosa. The purpose of the study is to evaluate the effects of two different medications, physiologic testosterone replacement and risedronate, on bone density in subjects with anorexia nervosa. Testosterone is a hormone that is made by the ovaries and adrenal glands in both women and men and has been shown to be important for prevention of osteoporosis and maintenance of muscle mass in men. Testosterone has been shown to stimulate bone forming cells called osteoblasts, and to increase bone formation and bone density in post-menopausal women, but its effects on bone formation or bone density in women with anorexia nervosa are not known. Actonel is a medication that is prescribed for low bone density to postmenopausal women.
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
神经性厌食症是一种进食障碍,可导致骨骼变薄(骨密度下降)。骨密度的显著下降称为骨量减少或骨质疏松。有时,骨密度的丧失可能会严重到足以导致骨骼断裂和骨折。目前尚不清楚是什么原因导致神经性厌食症患者的骨骼变薄。本研究的目的是评估两种不同的药物--生理性睾酮替代疗法和利塞膦酸对神经性厌食症患者骨密度的影响。睾酮是一种荷尔蒙,由女性和男性的卵巢和肾上腺产生,已被证明对预防男性骨质疏松症和维持肌肉质量非常重要。已有研究表明,睾酮可以刺激称为成骨细胞的骨形成细胞,并增加绝经后女性的骨形成和骨密度,但它对患有神经性厌食症的女性的骨形成或骨密度的影响尚不清楚。Actonel是一种针对绝经后妇女骨密度低的药物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANNE KLIBANSKI其他文献
ANNE KLIBANSKI的其他文献
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{{ truncateString('ANNE KLIBANSKI', 18)}}的其他基金
The Role of lncRNA MEG3 in Clinically Non-functioning Pituitary Adenomas
lncRNA MEG3 在临床无功能垂体腺瘤中的作用
- 批准号:
9215659 - 财政年份:2016
- 资助金额:
$ 2.2万 - 项目类别:
Hormonal Factors in the Treatment of Anorexia Nervosa
治疗神经性厌食症的激素因素
- 批准号:
8599482 - 财政年份:2010
- 资助金额:
$ 2.2万 - 项目类别:
IGF-1 and Bone Loss in Women with Anorexia Nervosa
神经性厌食症女性的 IGF-1 和骨质流失
- 批准号:
8063348 - 财政年份:2010
- 资助金额:
$ 2.2万 - 项目类别:
Hormonal Factors in the Treatment of Anorexia Nervosa
治疗神经性厌食症的激素因素
- 批准号:
8401158 - 财政年份:2010
- 资助金额:
$ 2.2万 - 项目类别:
PHYSIOLOGIC GH ADMIN ON CARDIOVASCULAR RISK MARKERS IN WOMEN WITH GH DEFICIENCY
GH 生理学管理对 GH 缺乏女性心血管风险标志物的影响
- 批准号:
7731234 - 财政年份:2008
- 资助金额:
$ 2.2万 - 项目类别:
THE EFFECT OF ANOREXIA NERVOSA ON PEAK BONE MASS
神经性厌食症对峰值骨量的影响
- 批准号:
7731313 - 财政年份:2008
- 资助金额:
$ 2.2万 - 项目类别:
HORMONE DYNAMICS AND BONE MINERAL DENSITY IN ANOREXIA NERVOSA VS HYPOTHALAMIC
神经性厌食症与下丘脑性厌食症的激素动态和骨矿物质密度
- 批准号:
7731326 - 财政年份:2008
- 资助金额:
$ 2.2万 - 项目类别:
CLINICAL TRIAL: EFFECTS OF SUPRAPHYSIOLOGICAL RHGH ON BONE METABOLISM IN ANOREXI
临床试验:超生理学 RHGH 对厌食症患者骨代谢的影响
- 批准号:
7731266 - 财政年份:2008
- 资助金额:
$ 2.2万 - 项目类别:
相似海外基金
THE EFFECTS OF TESTOSTERONE AND ACTONEL ON BONE DENSITY IN ANOREXIA NERVOSA
睾酮和 Actonel 对神经性厌食症骨密度的影响
- 批准号:
7607040 - 财政年份:2006
- 资助金额:
$ 2.2万 - 项目类别:
THE EFFECTS OF RHIGF-I AND ACTONEL ON BONE DENSITY IN ANOREXIA NERVOSA
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- 批准号:
7205042 - 财政年份:2004
- 资助金额:
$ 2.2万 - 项目类别:
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睾酮和 Actonel 对神经性厌食症骨密度的影响
- 批准号:
7205082 - 财政年份:2004
- 资助金额:
$ 2.2万 - 项目类别:
THE EFFECTS OF RHIGF-I AND ACTONEL ON BONE DENSITY IN ANOREXIA NERVOSA
RHIGF-I 和 Actonel 对神经性厌食症骨密度的影响
- 批准号:
6982560 - 财政年份:2003
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$ 2.2万 - 项目类别:
The effect of Chronic Malnutrition on growth and volumetric bone density in adolescents with Anorexia Nervosa
慢性营养不良对神经性厌食症青少年生长和骨密度的影响
- 批准号:
nhmrc : 987607 - 财政年份:1998
- 资助金额:
$ 2.2万 - 项目类别:
NHMRC Postgraduate Scholarships
EFFECTS OF RHIGF-1 AND ESTROGEN ON BONE DENSITY IN ANOREXIA NERVOSA
RHIGF-1 和雌激素对神经性厌食症骨密度的影响
- 批准号:
6280042 - 财政年份:1997
- 资助金额:
$ 2.2万 - 项目类别:
LONGITUDINAL STUDY OF BONE DENSITY IN ANOREXIA NERVOSA
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- 批准号:
3159597 - 财政年份:1989
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- 资助金额:
$ 2.2万 - 项目类别:














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