LONG TERM EFFECTS OF TESTOSTERONE IN HIV-INFECTED WOMEN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病毒感染妇女的雄激素缺乏症与肌肉减少症有关，并可能导致身体功能严重下降。在这些妇女中，肌肉质量减少是骨质减少的主要预测因素。此外，骨标志物表明，在这些患者中，骨形成相对减少，这也可能是由于成骨细胞功能的雄激素刺激减少所致。长期雄激素治疗对瘦体重、骨密度和其他临床终点（包括HIV感染女性的生活质量、功能状态、抑郁指数和神经认知功能）的影响尚不清楚。 与安慰剂治疗相比，在患有艾滋病消瘦的女性中，长期睾酮给药将增加骨密度和生活质量、功能状态、抑郁指数和神经认知功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Androgen deficiency in HIV-infected women is associated with sarcopenia and may cause critical reductions in physical functioning. Among such women, reduced muscle mass is a major predictor of osteopenia. Furthermore, bone markers suggest relatively reduced bone formation in such patients, which may also result from diminished androgenic stimulation of osteoblast function. The effects of long-term androgen therapy on lean body mass, bone density and other clinical endpoints including quality of life, functional status, depression indices and neurocognitive function in HIV-infected women are not known. Among women with AIDS wasting, long-term testosterone administration will increase bone density and quality of life, functional status, depression indices and neurocognitive function as compared to placebo treatment.