PHASE II RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED SAFETY AND PHARMACOKINETIC

II 期随机、双盲、安慰剂对照安全性和药代动力学

• 批准号: 7716605
• 负责人: KRISTI L. WATTERBERG
• 金额: $ 0.83万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716605
• 关键词: Birth; Computer Retrieval of Information on Scientific Projects Database; Dose; Double-Blind Method; Drug Kinetics; Funding; Grant; Infant; Inositol; Institution; Intravenous; Phase; Placebo Control; Pregnancy; Purpose; Randomized; Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; renal tubular reabsorption

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is: a. Determine the single-dose pharmacokinetics of intravenous inositol given at a dose of either 60 or 120 mg/kg soon after birth to extremely low gestation infants. b. Determine whether the pharmacokinetics of inositol are linar or nonlinear and determine whether nonlinearity may be related to saturable renal tubular reabsorption.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是： a. 测定极低妊娠期婴儿出生后立即静脉给予肌醇60或120 mg/kg单次给药的药代动力学。 B. 确定肌醇的药代动力学是线性的还是非线性的，并确定非线性是否可能与饱和肾小管重吸收有关。