NOCTURNAL SECRETION OF OVARIAN STEROIDS, LH, AND FSH IN ADOLESCENT GIRLS

青春期女孩卵巢类固醇、LH 和 FSH 的夜间分泌

• 批准号: 7718607
• 负责人: John C Marshall
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718607
• 关键词: Adolescent; Androgen Receptor; Androgens; Computer Retrieval of Information on Scientific Projects Database; Female Adolescents; Follicle Stimulating Hormone; Funding; Grant; Institution; Knowledge; Ovarian; Pattern; Polycystic Ovary Syndrome; Progesterone; Puberty; Research; Research Personnel; Resources; Source; Steroids; United States National Institutes of Health; Woman

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to polycystic ovary syndrome (PCOS). Women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility, likely due to elevated levels of androgens, as GnRH sensitivity can be restored to normal by androgen receptor blockade. We aim to examine the nocturnal secretory patterns of ovarian steroids, LH, & FSH in adolescent girls with or without elevated androgens during puberty. The results will advance our knowledge of the causes of PCOS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 青少年高雄激素血症似乎是多囊卵巢综合征（PCOS）的先兆。患有 PCOS 的女性对黄体酮抑制 GnRH 搏动的敏感性降低，可能是由于雄激素水平升高，因为 GnRH 敏感性可以通过雄激素受体阻断恢复到正常。我们的目的是检查青春期雄激素升高或不升高的青春期女孩的卵巢类固醇、LH 和 FSH 的夜间分泌模式。研究结果将增进我们对多囊卵巢综合症病因的了解。