PREVENTION OF ORAL CANCER BY TEA

通过茶预防口腔癌

• 批准号: 7719058
• 负责人: FUNG-LUNG CHUNG
• 金额: $ 57.69万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719058
• 关键词: Biological; Black Tea; Blood; Cells; Class; Clinic Visits; Computer Retrieval of Information on Scientific Projects Database; Control Groups; DNA Damage; Fatty Liver; Funding; Goals; Grant; Green tea; Incidence; Institution; Light; Malignant neoplasm of liver; Obesity; Oral; Participant; Placebos; Polyunsaturated Fatty Acids; Research; Research Personnel; Resources; Risk Factors; Role; Running; Sampling; Smoker; Source; Tea; United States National Institutes of Health; Urine; Water; Week; adduct; drinking; healthy volunteer; non-smoker; oral cancer prevention; oxidation; research clinical testing; treatment duration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.

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