PREVENTION OF ORAL CANCER BY TEA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.