PREVENTION OF ORAL CANCER BY TEA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 本研究针对健康志愿者。参与者将被分为两组：当前吸烟者和非吸烟者对照组。在两组中，每次治疗将饮用绿色茶和红茶、含咖啡因的水和水（安慰剂）4周，最初有3周的导入期和2周的“洗脱”期。在这些治疗期间，将每周采集一次口腔细胞，每周采集一次尿液样本，每两周采集一次血液。最初将对参与者进行临床评价，然后每月进行一次。要求受试者每周到诊所就诊一次。研究将持续25周，包括治疗。 我们的目标是研究一类由多不饱和脂肪酸（称为环状加合物）氧化形成的DNA损伤在导致肝癌中的特定生物学作用。肝癌的发病率在美国呈上升趋势，有证据表明肥胖和脂肪肝是潜在的危险因素。因此，我们的长期目标是产生信息，以阐明肝癌中肥胖的可能机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.