GENOTYPIC AND PHENOTYPIC RESPONSE OF BREAST EPITHELIAL CELLS FROM WOMEN

女性乳腺上皮细胞的基因型和表型反应

• 批准号: 7719026
• 负责人: Peter G. Shields
• 金额: $ 0.34万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719026
• 关键词: Apoptosis; Biological Markers; Blood; Breast; Carcinogen Metabolism; Carcinogens; Computer Retrieval of Information on Scientific Projects Database; DNA Damage; Data; Epithelial Cells; Funding; Genes; Genotype; Grant; Institution; Mammary Gland Parenchyma; Measures; Organ; Penetrance; Phenotype; Purpose; Recruitment Activity; Research; Research Personnel; Resources; Source; Swab; TP53 gene; Time; Tissues; United States National Institutes of Health; Urine; Woman; Work; cancer risk; gene environment interaction; repository; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose of project: I. Recruit women who are undergoing reduction mamoplasty to provide an epidemiological profile, blood, urine, and breast tissue, which will be established as a data and tissue repository. 2. Utilize the repository to study low penetrance genes, investigate gene-environment interactions and establish genotype-phenotype relationships involving carcinogen metabolism, DNA damage, and response to DNA damage, in order to identify or validate the use of intermediate biomarkers of cancer risk. 3. To identify the relationship of biomarkers measured in surrogate tissues such as blood, buccal swabs and urine to the level of the same biomarker in the breast tissue, which is the target organ for the carcinogens under study. PROVIDE TIME LINE AND WORK PLANNED FOR THE REMAINDER OF THIS PROJECT: THREE YEARS, ESTABLISH CULTURES, DETERMINE P53 AND APOPTOSIS RESPONSE TO DNA DAMAGE, AND THEN IDENTIFY THE GENES RESPONSIBLE FOR SUCH

这个子项目是众多研究子项目之一