Radiofrequency Transmit and Receive Upgrade for 3T Research Scanner
3T 研究扫描仪的射频发射和接收升级
基本信息
- 批准号:7794553
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAlzheimer&aposs DiseaseAnatomyArtsAttentionAutistic DisorderBrainBreastCoiled BodiesCore FacilityDevelopmental DisabilitiesDiffusion Magnetic Resonance ImagingDiseaseElementsEnvironmentFunctional Magnetic Resonance ImagingFundingGrantHIVHeadHeart DiseasesHumanHuntington DiseaseImageInstitutionInvestigationMagnetic ResonanceMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalignant neoplasm of brainMemoryMetabolic DiseasesModalityMultiple SclerosisNoisePhysiologicalPhysiologyReadingResearchResearch InstituteResearch PersonnelResolutionResourcesRett SyndromeScanningSignal TransductionSliceSystemTimeTissuesUniversitiesclinical applicationcognitive functiondesignimprovedinstrumentationpublic health relevanceradiofrequencysoftware systemsspectroscopic imaging
项目摘要
DESCRIPTION (provided by applicant): We propose to upgrade the radiofrequency (RF) capabilities of our 3T research scanner at the F.M. Kirby Research Center of the Hugo Moser Research Institute at Kennedy Krieger (KKI). The purpose is to remain a state-of-the-art MRI core facility by 1) extending the RF transmit capabilities to parallel transmit (TX) and upgrading to system release 3.0, and 2) increasing the number of head coil elements for brain studies to 32 receive channels. This is necessary to address the needs of many investigators at the KKI and Johns Hopkins University (JHU) who presently have 20 NIH-funded grants with several aims that can strongly benefit from the improved technical capabilities provided by this upgrade. These investigators use the 3T system in the F.M. Kirby Research Center for structural MRI, functional MRI (fMRI), quantitative physiological MRI, magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI), and diffusion tensor imaging (DTI) of a large range of diseases and developmental disabilities. This proposed instrumentation will provide the following benefits: 1) Body coil TX /Release 3.0 system: upgrades us to the latest system software and hardware and expands our capabilities to multi-channel (parallel) RF transmit. The latter allows for RF transmit field optimization (B1+ shimming) to reduce dielectric shading at 3T, caused by the RF wavelength being on the order of the subject size. This is important for homogeneous image intensity and contrast, which benefits quantitative assessment of tissue volumes, metabolite levels, and other physiological parameters. In addition, the Release 3.0 upgrade will allow dynamic slice-by-slice B0 adjustment, providing increased local SNR, reduced spatial distortions, and better temporal stability for fMRI. 2) 32-channel 1H receive-only head coil: Currently, the brain studies in the grants listed use the 8- channel receive coil. Compared to this, the 32-channel coil increases cortical signal-to-noise ratio (SNR) by more than 50% and the coil design allows the efficient use of high acceleration factor SENSE imaging in all three directions. This is due to a large reduction in the noise-amplification factor (g-factor), which can be more than 40-80% depending on the acceleration rate and directions used. These primary advantages can be used to: a) better detect small signals (MRS) or small signal changes (fMRI); b) increase spatial resolution for all modalities; c) reduce scan times (i.e., yield shorter scans) for especially in 3D acquisition sequences for structural MRI and MRSI; d) reduce spatial distortions in fast single-shot acquisitions, such as used for DTI and fMRI. This 3T RF transmit/receive upgrade is essential for continued high-quality state-of-the-art research for the NIH-funded researchers at our institutions who are served by the core facilities of our NIH/NCRR Research Resource.
PUBLIC HEALTH RELEVANCE: The proposed system upgrades will benefit all researchers using the F.M. Kirby Research Center at the Hugo Moser Research Institute at Kennedy Krieger. The Center provides a core magnetic resonance facility within an interdisciplinary environment for the investigation of human anatomy, function and physiology. Cognitive functions including memory, attention, reading ability, and others are studied in conditions such as autism, Rett syndrome, and many other developmental disabilities. Other clinical applications include imaging studies of cancer (brain, breast), Huntington's disease, Alzheimer's disease, HIV, multiple sclerosis, cardiac disease, and rare metabolic disorders.
描述(由申请人提供):我们建议升级 F.M. 的 3T 研究扫描仪的射频 (RF) 功能。肯尼迪克里格 (KKI) 雨果·莫泽研究所的柯比研究中心。其目的是通过以下方式保持最先进的 MRI 核心设施:1) 将 RF 传输能力扩展到并行传输 (TX) 并升级到系统版本 3.0,以及 2) 将用于大脑研究的头部线圈元件数量增加到 32 个接收通道。这对于满足 KKI 和约翰霍普金斯大学 (JHU) 的许多研究人员的需求是必要的,他们目前拥有 20 项 NIH 资助的赠款,其多个目标可以从此次升级提供的改进的技术能力中受益匪浅。这些调查人员使用 F.M. 中的 3T 系统。柯比研究中心致力于研究多种疾病和发育障碍的结构 MRI、功能 MRI (fMRI)、定量生理 MRI、磁共振波谱 (MRS) 和光谱成像 (MRSI) 以及扩散张量成像 (DTI)。该提议的仪器将提供以下好处: 1) 体线圈 TX/Release 3.0 系统:将我们升级到最新的系统软件和硬件,并将我们的能力扩展到多通道(并行)射频传输。后者允许 RF 发射场优化(B1+ 匀场),以减少 3T 时的介电遮蔽,这是由 RF 波长与对象尺寸相当的量级引起的。这对于均匀的图像强度和对比度非常重要,有利于组织体积、代谢物水平和其他生理参数的定量评估。此外,3.0版升级将允许动态逐片B0调整,为fMRI提供更高的局部SNR、减少空间失真和更好的时间稳定性。 2)32通道1H仅接收头部线圈:目前,列出的资助中的大脑研究使用8通道接收线圈。与此相比,32通道线圈将皮质信噪比(SNR)提高了50%以上,并且线圈设计允许在所有三个方向上高效利用高加速因子SENSE成像。这是由于噪声放大系数(g 系数)大幅降低,根据所使用的加速度和方向,噪声放大系数可能超过 40-80%。这些主要优点可用于: a) 更好地检测小信号 (MRS) 或小信号变化 (fMRI); b) 提高所有模式的空间分辨率; c) 减少扫描时间(即,产生更短的扫描),特别是在结构 MRI 和 MRSI 的 3D 采集序列中; d) 减少快速单次采集中的空间失真,例如用于 DTI 和 fMRI。 这种 3T RF 发射/接收升级对于我们机构中由 NIH 资助的研究人员持续进行高质量的最先进研究至关重要,这些研究人员由 NIH/NCRR 研究资源的核心设施提供服务。
公共卫生相关性:拟议的系统升级将使所有使用 F.M. 的研究人员受益。肯尼迪克里格雨果莫泽研究所的柯比研究中心。该中心在跨学科环境中提供核心磁共振设施,用于研究人体解剖学、功能和生理学。研究人员在自闭症、雷特综合征和许多其他发育障碍等疾病中研究了记忆、注意力、阅读能力等认知功能。其他临床应用包括癌症(脑癌、乳腺癌)、亨廷顿病、阿尔茨海默病、HIV、多发性硬化症、心脏病和罕见代谢性疾病的成像研究。
项目成果
期刊论文数量(0)
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Peter CM Van Zijl其他文献
Peter CM Van Zijl的其他文献
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