Small Animal Imaging Shared Resource

小动物成像资源提供使用多种模态的成像，包括深度解析或 平面荧光和生物发光成像、MRI、PET/CT和平面动脉造影。一些 有经验的研究者和技术人员，能够进行成像和数据辅助 解释与资源有关。有动物处理的基础设施（例如，麻醉， 输注，监测生命体征），并可促进和开展发展研究， 新的成像方案和方法评价。该资源由放射化学支持 实验室和分子合成实验室，并具有数据分析和存档的计算机能力。 小动物成像资源一直在促进和加强细胞和分子成像， 近十年来，基础设施建设不断发展。定期举办研讨会和专题讨论会， 激发了来自不同背景的科学家和医生（工程师， 化学家、分子生物学家和肿瘤学家）将成像应用于肿瘤学问题， 通过向几个人提供赠款来认可。该资源部分由U24 SAIRP（Pis Ralph）支持 Mason和Dean Sherry）于2007年4月开始。资源作为新的催化剂， 协调新基础设施的合作和重点，例如，获得NIH共享仪器赠款 2008年，Insfitutional获得了Caliper（Xenogen）Spectrum的专利，并投资于小动物MRI和PET/CT。 影像学（放射学）和组织学（病理学）是大多数临床查房和诊断的基础。 越来越多地，成像过滤到小动物研究，与优化的可用性相一致， 成像仪器人们认识到，分子生物学和药物设计的进步必须 移至体内评估。成像允许动物（肿瘤）作为自己的对照，实质上 提高研究效率。在许多情况下，动物模型（例如，转基因和敲除）是 非常舒适和/或供应不足。许多试剂，例如，可获得新的治疗性抗体 只是少量的需要更少的动物，节省成本，满足生物医学伦理目标 research.因此，最大限度地提高从个体受试者获得的数据的信息和质量， 提高研究效率，最终达到临床应用的目的。

The Small Animal Imaging Resource provides imaging using multiple modalifies including depth resolved or planar fluorescence and bioluminescent imaging, MRI, PET/CT, and planar scintigraphy. A number of experienced investigators and technical staff capable of undertaking imaging and assisfing in data interpretation are associated with the Resource. There is infrastructure for animal handling (e.g., anesthesia, infusion, monitoring vital signs) and can facilitate and undertake developmental studies for implementafion of new imaging protocols and evaluafion of methods. The Resource is supported by a radiochemistry laboratory and molecular synthesis laboratory and has computer capabilities for data analysis and archiving. The Small Animal Imaging Resource has been promofing and enhancing cellular and molecular imaging for the last 10 years and has developed substanfial infrastructure. Regular seminars and symposia have stimulated increasing interest among scienfists and physicians from diverse backgrounds (engineers, chemists, molecular biologists, and oncologists) to apply imaging to questions in oncology and this has been recognized by grants to several individuals. The Resource supported in part by a U24 SAIRP (Pis Ralph Mason and Dean Sherry) commenced in April 2007. The Resource serves as a catalyst for new collaborations and focus for coordinating new infrastructure, e.g., winning NIH Shared instrumentation grants for a Caliper (Xenogen) Spectrum in 2008 and Insfitutional investment in small animal MRI and PET/CT. Imaging (radiology) and histology (pathology) are the cornerstones of most clinical rounds and diagnoses. Increasingly, imaging is filtering down to small animal research, coinciding with the availability of opfimized imaging instrumentafion. There is a realization that progress in molecular biology and drug design must move to assessment in vivo. Imaging allows animals (tumors) to serve as their own controls, substanfially improving research efficiency. In many cases, animal models (e.g., transgenic and knockout) are exceedingly cosfiy and/or in short supply. Many reagents, e.g., novel therapeufic anfibodies are available only in small quantifies. Fewer animals are needed, saving on cost and meefing ethical goals for biomedical research. Thus, maximizing the information and quality of data obtained from individual subjects should enhance research efficiency and ulfimate translafion to the clinic.