Understanding and preventing breast cancer disparties in Latinas

描述(申请人提供)：乳腺癌是美国最常见的拉美裔女性癌症。拉美裔美国人的乳腺癌发病率(83.5/100,000)低于非西班牙裔白人(147.3/100,000)；然而，随着拉美裔妇女采用美国主流文化的做法，她们患乳腺癌的风险增加。此外，拉美裔妇女患乳腺癌的风险更高，预后也很差。这一PSO应用程序的首要主题是了解和预防乳腺癌的前兆，并降低拉丁裔人的乳腺癌发病率和死亡率。这将在多个层面上进行，并将吸引多个学科的研究人员参与。项目经过精心设计，以促进对拉丁裔乳腺癌的了解和预防。该PSO应用程序的长期目标是了解拉丁裔人群中乳腺癌的前驱因素，了解拉丁裔人群中发现的乳腺癌类型，并开发和实施一项全面的筛查计划，以增加拉丁裔人群中早期乳腺癌的发现机会。我们的短期目标是： 1.在符合年龄条件的拉丁裔中增加乳腺癌筛查； 2.了解拉丁裔人的血统、体重指数、炎症和乳腺癌之间的关系 3.通过识别与三阴性(TN)和HER-2过度表达(HER-2)肿瘤相关的危险因素，了解预后不良乳腺癌的病因方面，与非西班牙裔白人相比，三阴性(TN)和HER-2过度表达(HER-2)肿瘤在拉丁裔更常见 4.了解血统在拉丁裔乳腺癌先证者和发病率中的作用。 5.探讨肿瘤相关通路信号转导相关基因的表达。这项申请致力于以一种全面的、多层次的方法来减少健康差距。它的项目范围从生物和遗传到人们生活的社会背景。通过其四个项目和核心，拟议的中心将涵盖乳腺癌的许多方面，从生物学过程和遗传途径到乳腺癌的个人决定因素和社会决定因素。

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among Hispanic women in the United States (US). The incidence of breast cancer among Hispanics (83.5 per 100,000) is lower than that among non-Hispanic Whites (147.3 per 100,000); however, as Hispanic women adopt the practices of mainstream US culture, their risk for breast cancer increases. Further, Hispanic women are at increased risk for breast cancers with poor prognosis. The overarching theme of this PSO application is to understand and prevent pre-cursors of breast cancer and to reduce breast cancer morbidity and mortality among Latinas. This will be done at multiple levels and will engage researchers across several disciplines. Projects have been carefully designed to contribute understanding to and preventing breast cancer in Latinas. It is the lonq-term goal of this PSO application to understand the antecedents of breast cancer in the Latina population, to understand the types of breast cancer found in the Latina population, and develop and implement a comprehensive program of screening to increase the opportunities for early breast cancer detection among Latinas. Our short-term obiectives are to: 1. Increase breast cancer screening among age-eligible Latinas; 2. Understand the processes by which ancestry, BMI, inflammation, and breast cancer are related in Latinas 3. To understand aspects of the etiology of poor prognosis breast cancers by identifying risk factors related to triple negative (TN) and HER-2-overexpressing (H2E) tumors, which are more commonly found in Latinas compared to non-Hispanic whites 4. To understand the role of ancestry in breast cancer antecedents and incidence among Latinas. 5. To explore expression of genes involved in tumor-related pathways signaling. This application is committed to a comprehensive multi-level approach to reducing health disparities. Its projects range from the biologic and genetic to the social context within which people live. Through its four projects and cores, the proposed Center will cover a myriad of aspects of breast cancer, from biological processes and genetic pathways to individual determinants and social determinants of breast cancer.