黄色粘球菌的细胞间信号转导-猫眼课题宝

黄色粘球菌的细胞间信号转导

批准号：

7813783

负责人：

Wenyuan Shi

金额：

$34.04万

依托单位：

UNIVERSITY OF CALIFORNIA LOS ANGELES

依托单位国家：

美国

项目类别：

财政年份：

1996

资助国家：

美国

项目状态：

已结题

起止时间：

1996-08-01 至 2012-04-30

来源：

https://reporter.nih.gov/project-details/7813783

关键词：

Adherence Amino Acids Antibodies Bacteria Behavior Binding Biochemical Biochemistry Bioinformatics Biological Biological Models Candidate Disease Gene Cell membrane Cell physiology Cell surface Cells Chemicals Chemotaxis Complex Cytoplasm Data Development Event Flagella Frequencies Fruit Future Gene Expression Genes Genetic Genome Grant Homologous Gene Ion Channel Knowledge Label Lead Lectin Life Cycle Stages Location Measures Mechanics Membrane Methylation Microbial Biofilms Microscopic Modeling Modification Molecular Molecular Analysis Monitor Morphogenesis Motion Motor Mutagenesis Mutate Myxococcus xanthus Nature Operon Pathogenesis Pattern Phage Attachment Site Phenotype Physiological Physiology Pilum Plasmids Post-Translational Protein Processing Posttranslational Amino Acid Modification Production Property Proteins Proteomics Reagent Regulation Reporter Research Personnel Resistance Role Signal Transduction Site Social Behavior Solid Spatial Distribution Surface Swimming System Techniques Testing Time Tissues Touch sensation Transcriptional Regulation Virulent base cell motility combat epsin extracellular fascinate follow-up genetic analysis genetic regulatory protein improved insight microbial mutant neuronal cell body pathogenic bacteria research study scaffold sensor sensory system social tool

项目摘要

项目成果

Wenyuan Shi的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION (provided by applicant): Intercellular signaling is essential for complex microbial events such as development, pathogenesis and biofilm formation. Myxococcus xanthus is an excellent model bacterium for studying intercellular signaling because of its complex life cycle and coordinated social behaviors. This study focuses on M. xanthus social gliding motility and chemotaxis, a multi-cellular function involved in vegetative swarming and fruiting body formation. Previous studies show that social gliding motility/chemotaxis of M. xanthus involves the complex interactions of three major cellular components: type IV pili (TFP), exopolysacchrides (EPS), and a chemotaxis-like Frz sensory system (Frz). This study aims to understand the genetic and biochemical basis of M. xanthus social gliding motility/chemotaxis. Three specific aims are proposed in this application. Aim 1 is to analyze the genetic and biochemical properties of PilA to further understand the role of TFP in S-motility. Aim 2 is to study the molecular mechanisms associated with temporal and spatial control of EPS production and distribution to further understand the role of EPS in S-motility. Aim 3 is to explore the interaction between TFP & EPS and its associated biological events. The successful execution of these proposed studies will provide a molecular understanding of the TFP-EPS-Frz-associated social gliding motility and chemotaxis. The findings will reveal insightful biological knowledge about intercellular signaling events during the complex development of M. xanthus. Furthermore, these studies could discover the possible evolutionary connections between flagella based swimming motility and TFP dependent gliding motility. Since TFP, EPS and chemosensory proteins are also the key virulent factors for a variety of pathogenic bacteria during biofilm formation and tissue adherence and invasion, the knowledge gained from this study could also lead to new ways to combat microbial pathogenesis.

期刊论文(35)

专著(0)

科研奖励(0)

会议论文