Academic Training Program in Pediatric Pulmonary Disease

描述（由申请人提供）：由于缺乏对疾病基本机制的了解和新的治疗策略的发展，我们对儿童呼吸系统疾病的理解和治疗的进展受到限制。该计划的目的是为对儿童肺部疾病感兴趣的学术导向的儿科医生提供严格的多学科培训。该提案是科罗拉多大学医学院NIH儿科肺脏疾病培训计划的更新，并代表了自1988年以来存在的完善计划的延续。目前的建议已经扩大，以代表我们的培训计划的演变，并反映我们的高度互动，多学科的教师。该项目的优势包括整合两家合作医院（儿童医院（TCH）和国家犹太医学研究中心（ncc））以及ncc和UCHSC校园的五个研究单位（发育肺生物学实验室，儿科心肺中心实验室，围产期研究设施，再生医学和心血管肺实验室）的广泛资源所带来的好处。这些资源被组合成一个多功能的训练环境，用于基础研究和应用研究。该计划的教师包括PPGs的Pis， SCCORs，囊性纤维化治疗发展中心奖，NIH临床研究中心奖，以及几个解决肺生物学领域基础，应用和临床研究问题的个人奖项。实验室和临床研究人员之间的合作是该提案的主要优势，加强了来自不同背景的科学家和临床医生之间的互动，并鼓励“从实验室到床边”的儿科肺病治疗方法。培训项目的所有参与者都是全职的学术人员，包括儿科肺病和重症监护医师-调查员，以及来自UCHSC的几位基础（博士）和其他科学家。从我们的儿科肺科、重症监护和新生儿奖学金培训项目的候选人中挑选出具有明确学术目标的最有前途的个人。经过一年的临床培训（由其他来源资助），在高级研究员的直接指导下提供实验室或临床研究经验。为学员提供统计学、分子生物学、细胞生理学、伦理学和其他领域的结构化课程。（摘要结束）

DESCRIPTION (provided by applicant): Advances in our understanding and treatment of childhood respiratory disorders have been limited by a lack of insight into basic mechanisms of disease and the development of novel therapeutic strategies. The purpose of this program is to provide rigorous multidisciplinary training for academically oriented pediatricians interested in childhood lung diseases. This proposal is a reneal of the NIH Training Program in Pediatric Pulmonary Lung Disease at the University of Colorado School of Medicine, and represents the continuation of a well-established program that has ixisted since 1988. This current proposal has been expanded to represent the evolution of our training program and to refelct our highly interactive, multidisciplinary faculty. Strengths of this program include benefits derived from the integration of extensive resources of two collaborating hospitals (The Children's Hospital (TCH) and National Jewish Medical and Research Center (NJC)) and five research units at NJC and the UCHSC campus (Developmental Lung Biology Laboratory, Pediatric Heart Lung Center Laboratory, the Perinatal Research Facility, Regenerative Medicine and the Cardiovascular Pulmonary Laboratories). These resources are combined into a versatile training evnironment for both basic and applied research. Faculty in this program include the Pis of PPGs, SCCORs, a Therapeutic Development Center Award in Cystic Fibrosis, and NIH Clinical Research Center Grant, and several individual awards that address basic, applied and clinical research questions in the area of pulmonary biology. Collaborations between laboratory and clinical investigators are a major strength of this proposal, enhancing interactions between scientists and clinicians from diverse backgrounds and encouragaing "bench to bedside" approaches to pediatric lung disease. All participants in the training program are full-time academic faculty, and include pediatric pulmonary and critical care physican- investigators, along with several basic (PhD) and other scientists from throughout the UCHSC. The most promising individuals with clearly defined academic goals are selected from candidates within our pediatric pulmonary, critical care and neonatology fellowship training programs. After a clinical year of training (funded from other sources), laboratory or clinical research experience is provided under the direct mentorship of a senior investigator. Structured course work in statistics, molecular biology, cell physiology, ethics, and other areas are provided to trainees. (End of Abstract)