TOPICAL MICROBICIDE AGAINST SIV AND CHLAMYDIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：测试一种潜在的杀微生物剂预防艾滋病毒传播给妇女的效果。迫切需要这样一种有效的药剂，以遏制全球妇女艾滋病毒新感染率的显著上升。 该提案在体内测试了甘油单月桂酸酯预防猴免疫缺陷病毒阴道内传播至恒河猴的有效性，恒河猴是HIV性粘膜传播的高度相关非人灵长类动物模型。我们发现甘油单月桂酸酯不会改变恒河猴（猕猴）阴道乳酸杆菌，长期使用是安全的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test the efficacy of a potential microbicidal agent to prevent transmission of HIV to women. Such an effective agent is urgently needed to combat the predominant rise globally of new HIV infections in women. This proposal tested in vivo the efficacy of glycerol monolaurate to prevent intravaginal transmission of simian immunodeficiency virus to rhesus macaques, a highly relevant nonhuman primate model of sexual mucosal transmission of HIV. We found that glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginallactobacilli and is safe for chronic use.