A Wearable Wireless System for Real-Time Monitoring of Chemical Toxicants

用于实时监测化学毒物的可穿戴无线系统

• 批准号: 7894022
• 负责人: NONGJIAN TAO
• 金额: $ 63.7万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7894022
• 关键词: Achievement; Air; Air Pollution; Arizona; Asthma; Autistic Disorder; Benzene; Breathing; Cellular Phone; Chemical Exposure; Chemicals; Chronic Disease; Collaborations; Communication; Communication Aids for Disabled; Computer software; Computers; Consumption; Data; Data Analyses; Data Collection; Detection; Development; Devices; Diabetes Mellitus; Disease; Electronics; Elements; Engineering; Environment; Environmental Exposure; Environmental Pollutants; Epidemiologist; Epidemiology; Exposure to; Feasibility Studies; Gases; Genes; Goals; Health; Housing; Human; Hybrids; Individual; Industry; Laboratories; Lead; Link; Location; Measurement; Measures; Mechanics; Methods; Monitor; Occupational; Occupations; Performance; Persons; Play; Polymers; Population Study; Process; Questionnaires; Real-Time Systems; Recording of previous events; Research; Resources; Role; Sampling; Scientist; Signal Transduction; Specificity; System; Technology; Technology Transfer; Telephone; Testing; Time; Toluene; Toxic Environmental Substances; Universities; Validation; Wireless Technology; Work; Xylene; air sampling; base; cancer type; cost; design; epidemiology study; ethylbenzene; expectation; experience; flexibility; gene environment interaction; health disparity; human disease; monitoring device; novel; novel strategies; occupational health/safety; parent grant; pollutant; product development; programs; public health relevance; real world application; research and development; response; sensor; success; tool; toxicant; trafficking; transmission process; volatile organic compound

DESCRIPTION (provided by applicant): Evidence has shown that the recent increases in chronic diseases, such as asthma, certain type of cancers, diabetes and autism, are linked to the exposure of individuals to various environmental pollutants. In order to fully establish the correlation between a disease and a specific pollutant, new tools to measure personal environmental exposures are required. As a response to this need, an interdisciplinary team has been assembled to develop, build and test a wearable wireless sensor system for real time detection of toxic volatile organic compounds in air,-and the effort has been supported by the NIH/NIEHS Gene-Environment Initiative (GEI) program. Over the past two years, substantial advances have been made towards the final goal. Important achievements include successfully development of a wearable device that can detect ppbV level environmental pollutants in real time; seamless communication of the wearable device with a cell phone that can receive, process, display and store the sensor data; and demonstration of the wearable wireless sensor system for real world applications at indoors, gas stations and airport. Building upon the success, this revision project will expand the scope of the parent grant by exploring two particularly exciting new opportunities: 1 )development of a new hybrid detection method for Benzene, Toluene, Ethylbenzene and Xylenes (BTEX) that can provide unparalleled performance for determining personal exposure levels; and 2) working with epidemiologists to apply the new sensing tools to subsets of existing population studies of traffic-related air pollution, a primary cause of common diseases such as asthma. The hybrid detection unit will be built and integrated into the existing wearable device to work synergistically, providing new important functions to epidemiologists. It should be noted that the current commercial devices not only are bulky and expensive but also lack the selectivity to detect and analyze low ppb-levels of BTEX, which are thus not suitable for the epidemiology studies. The collaboration with epidemiologists will accelerate the transition from research and development to field test and validation. This revision effort will also lead to job creation and technology transfer from universities to industry. PUBLIC HEALTH RELEVANCE: A novel approach will be developed to detect, quantify and identify BTEX associated with road traffic activities. The approach is designed to provide otherwise unavailable high quality chemical exposure information and serve as a tool to dramatically advance epidemiological and occupational studies.

描述(由申请人提供)：有证据表明，哮喘、某些类型的癌症、糖尿病和自闭症等慢性病最近的增加与个人接触各种环境污染物有关。为了充分确定疾病和特定污染物之间的相关性，需要新的工具来衡量个人环境暴露。作为对这一需求的回应，已经组建了一个跨学科的团队来开发、建造和测试一种可穿戴的无线传感器系统，用于实时检测空气中的有毒挥发性有机化合物--这项努力得到了NIH/NIEHS基因环境倡议(GEI)计划的支持。在过去两年中，朝着最终目标取得了实质性进展。重要成就包括成功开发了可穿戴设备，可以实时检测ppbv水平的环境污染物；可穿戴设备与可以接收、处理、显示和存储传感器数据的手机进行无缝通信；以及可穿戴无线传感器系统的演示，用于室内、加油站和机场的真实应用。在成功的基础上，这一修订项目将通过探索两个特别令人兴奋的新机会来扩大父母资助的范围：1)开发一种新的苯、甲苯、乙苯和二甲苯(BTEX)混合检测方法，可以在确定个人接触水平方面提供无与伦比的性能；2)与流行病学家合作，将新的传感工具应用于与交通相关的空气污染的现有人口研究的子集，这是哮喘等常见疾病的主要原因。混合检测单元将被构建并整合到现有的可穿戴设备中，以协同工作，为流行病学家提供新的重要功能。应该指出的是，目前的商业设备不仅体积庞大、价格昂贵，而且缺乏检测和分析低ppb水平的苯系物的选择性，因此不适合进行流行病学研究。与流行病学家的合作将加快从研究和开发到现场测试和验证的过渡。这一修订努力还将导致创造就业机会和将技术从大学转移到行业。 公共卫生相关性：将开发一种新的方法来检测、量化和识别与道路交通活动相关的苯系物。该方法旨在提供其他方面无法获得的高质量化学品暴露信息，并作为一种工具，极大地促进流行病学和职业研究。