Translational Approaches to the Study of Emotion in Self-Injury

自伤情绪研究的转化方法

• 批准号: 7905976
• 负责人: Catherine Rose Glenn
• 金额: $ 2.95万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2011-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905976
• 关键词: Accounting; Adolescent; Affect; Affective; Arousal; Aversive Stimulus; Behavior; Blinking; Borderline Personality Disorder; Child; Control Groups; DSM-V; Data; Development; Diagnostic; Dialectical behavior therapy; Disease; Distress; Emotional; Emotions; Etiology; Feeling; Frequencies; Goals; Image; Impairment; Individual; Informal Social Control; Inpatients; International; Knowledge; Laboratories; Laboratory Study; Manuals; Measures; Modeling; Nature; Patient Self-Report; Physiological; Prevention; Process; Protocols documentation; Proxy; Psychological reinforcement; Psychophysiology; Public Health; Punishment; Recovery; Reflex action; Reporting; Research; Role; Sampling; Science; Self-Injurious Behavior; Societies; Source; Stimulus; Study Section; Sum; Time; Tissues; base; design; effective intervention; emotion regulation; emotional experience; emotional reaction; emotional stimulus; improved; indexing; injured; non-suicidal self injury; peer; public health relevance; response; suicidal; translational approach; treatment program; young adult

DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) describes the deliberate and direct injuring of body tissue without suicidal intent for purposes not socially sanctioned (International Society for the Study of Self-injury; ISSS). Converging evidence suggests that the most common function of NSSI is to regulate negative emotional experiences (e.g., to stop bad feelings). In fact, self-injurers report more frequent and intense negative emotions, a reduction in negative emotions following a self-injurious act, and more emotion dysregulation than non-injurers. Taken together, research suggests that NSSI serves an emotion regulation function for individuals who struggle to regulate emotion. Therefore, careful examination of emotion dysregulation in NSSI could substantially improve knowledge about etiology, prevention, and treatment. Thus far, most of what we know about emotion in NSSI is based on self-report studies, which arguably provide only a crude understanding of emotional deficits. Research guided by an affective science framework could provide more nuanced and clinically useful information about emotion in NSSI. Specifically, emotion can be separated into multiple components, each of which represents a potential source of impairment in disorders characterized by emotion dysregulation. The present study will apply this framework to the study of emotion in NSSI by employing the eyeblink startle reflex, a well-validated physiological measure used to study emotional processing. More specifically, two possible sources of emotion dysregulation will be examined: the magnitude of the startle reflex will be measured 1) during the presentation of emotional and neutral pictures (i.e., to index emotional reactivity) and 2) several seconds following the presentation of these stimuli (i.e., to index return to emotional baseline). The time-course of emotional recovery following aversive stimuli will be further examined in a second study. The study protocol will be administered to a self-injuring and two non-injuring control samples (i.e., affectively distressed non-injurers and non-affectively distressed non-injurers).The long-term goal is to generate more precise knowledge regarding the source and nature of emotional dysregulation in NSSI that can guide the design and implementation of treatments. PUBLIC HEALTH RELEVANCE: Rates of NSSI are disproportionately high in adolescents and young adults. Other than Dialectical Behavior Therapy (DBT), which is an intensive, most often inpatient, treatment program for self-injurers with borderline personality disorder, there is currently no treatment for self-injury. This project represents the first step in a programmatic line of research to generate clinically useful models of emotion dysregulation in NSSI to guide the development of effective interventions.

描述（由申请人提供）：非自杀性自伤 (NSSI) 是指为了不受社会认可的目的而故意和直接伤害身体组织，而没有自杀意图（国际自伤研究学会；ISSS）。综合证据表明，NSSI 最常见的功能是调节负面情绪体验（例如，停止不良情绪）。事实上，自残者比非自残者报告更频繁和强烈的负面情绪，自残行为后负面情绪减少，以及更多的情绪失调。综上所述，研究表明 NSSI 对于难以调节情绪的个体具有情绪调节功能。因此，仔细检查 NSSI 的情绪失调可以极大地提高对病因、预防和治疗的认识。到目前为止，我们对 NSSI 情绪的了解大多基于自我报告研究，可以说这些研究仅提供了对情绪缺陷的粗略理解。以情感科学框架为指导的研究可以提供有关 NSSI 情绪的更细致和临床有用的信息。具体来说，情绪可以分为多个组成部分，每个组成部分都代表了以情绪失调为特征的疾病的潜在损害来源。本研究将通过使用眨眼惊吓反射（一种用于研究情绪处理的经过充分验证的生理测量方法）将此框架应用于 NSSI 中的情绪研究。更具体地说，将检查情绪失调的两个可能来源：将测量惊吓反射的强度：1）在呈现情绪和中性图片期间（即，索引情绪反应性）和2）呈现这些刺激后几秒钟（即，索引返回到情绪基线）。第二项研究将进一步研究厌恶刺激后情绪恢复的时间过程。该研究方案将针对一个自伤者和两个非伤害者对照样本（即情感上痛苦的非伤害者和非情感上痛苦的非伤害者）进行。长期目标是获得有关 NSSI 情绪失调的来源和性质的更准确的知识，以指导治疗的设计和实施。公共卫生相关性：青少年和年轻人的 NSSI 发生率异常高。辩证行为疗法（DBT）是一种针对患有边缘性人格障碍的自伤者的强化治疗方案，通常是住院治疗，除此之外，目前还没有针对自伤的治疗方法。该项目代表了一系列研究的第一步，旨在生成临床上有用的 NSSI 情绪失调模型，以指导有效干预措施的开发。