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Translational Approaches to the Study of Emotion in Self-Injury

自伤情绪研究的转化方法

基本信息

批准号：
8070428
负责人：
Catherine Rose Glenn
金额：
$ 0.11万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2011-07-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8070428
关键词：
Accounting Adolescent Affect Affective Arousal Aversive Stimulus Behavior Blinking Borderline Personality Disorder Child Control Groups DSM-V Data Development Diagnostic Dialectical behavior therapy Disease Distress Emotional Emotions Etiology Feeling Frequencies Goals Health Image Impairment Individual Informal Social Control Inpatients International Knowledge Laboratories Laboratory Study Manuals Measures Modeling Nature Patient Self-Report Physiological Prevention Process Protocols documentation Proxy Psychological reinforcement Psychophysiology Public Health Punishment Recovery Reflex action Reporting Research Role Sampling Science Self-Injurious Behavior Societies Source Stimulus Study Section Sum Time Tissues base design effective intervention emotion regulation emotional experience emotional reaction emotional stimulus improved indexing injured non-suicidal self injury peer response suicidal translational approach treatment program young adult

项目摘要

DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) describes the deliberate and direct injuring of body tissue without suicidal intent for purposes not socially sanctioned (International Society for the Study of Self-injury; ISSS). Converging evidence suggests that the most common function of NSSI is to regulate negative emotional experiences (e.g., to stop bad feelings). In fact, self-injurers report more frequent and intense negative emotions, a reduction in negative emotions following a self-injurious act, and more emotion dysregulation than non-injurers. Taken together, research suggests that NSSI serves an emotion regulation function for individuals who struggle to regulate emotion. Therefore, careful examination of emotion dysregulation in NSSI could substantially improve knowledge about etiology, prevention, and treatment. Thus far, most of what we know about emotion in NSSI is based on self-report studies, which arguably provide only a crude understanding of emotional deficits. Research guided by an affective science framework could provide more nuanced and clinically useful information about emotion in NSSI. Specifically, emotion can be separated into multiple components, each of which represents a potential source of impairment in disorders characterized by emotion dysregulation. The present study will apply this framework to the study of emotion in NSSI by employing the eyeblink startle reflex, a well-validated physiological measure used to study emotional processing. More specifically, two possible sources of emotion dysregulation will be examined: the magnitude of the startle reflex will be measured 1) during the presentation of emotional and neutral pictures (i.e., to index emotional reactivity) and 2) several seconds following the presentation of these stimuli (i.e., to index return to emotional baseline). The time-course of emotional recovery following aversive stimuli will be further examined in a second study. The study protocol will be administered to a self-injuring and two non-injuring control samples (i.e., affectively distressed non-injurers and non-affectively distressed non-injurers).The long-term goal is to generate more precise knowledge regarding the source and nature of emotional dysregulation in NSSI that can guide the design and implementation of treatments. PUBLIC HEALTH RELEVANCE: Rates of NSSI are disproportionately high in adolescents and young adults. Other than Dialectical Behavior Therapy (DBT), which is an intensive, most often inpatient, treatment program for self-injurers with borderline personality disorder, there is currently no treatment for self-injury. This project represents the first step in a programmatic line of research to generate clinically useful models of emotion dysregulation in NSSI to guide the development of effective interventions.

描述(由申请人提供)：非自杀性自残(NSSI)是指出于未经社会认可的目的故意和直接伤害身体组织而没有自杀意图的行为(国际自伤研究学会；ISSS)。越来越多的证据表明，NSSI最常见的功能是调节负面情绪体验(例如，停止不良情绪)。事实上，自伤者比非自伤者报告更频繁和更强烈的负面情绪，自我伤害行为后负面情绪的减少，以及更多的情绪失调。总而言之，研究表明，NSSI对努力调节情绪的人起到了情绪调节功能。因此，在NSSI中仔细检查情绪失调可以极大地提高对病因、预防和治疗的知识。到目前为止，我们在NSSI中对情绪的了解大多是基于自我报告研究，这些研究可以说只提供了对情绪缺陷的粗略理解。在情感科学框架的指导下进行的研究可以提供关于NSSI中情绪的更细微的和临床有用的信息。具体地说，情绪可以分为多个成分，每一个成分都代表着以情绪失调为特征的障碍的一个潜在的损害来源。本研究将把这一框架应用于NSSI中的情绪研究，采用眨眼惊吓反射，这是一种用于研究情绪加工的有效生理测量。更具体地说，将研究情绪失调的两个可能来源：惊吓反射的大小将被测量：1)在情绪和中性图片的呈现期间(即，指示情绪反应)和2)这些刺激呈现后的几秒钟(即，指示回到情绪基线)。厌恶刺激后情绪恢复的时间进程将在第二项研究中进一步研究。研究方案将应用于一个自我伤害和两个非伤害对照样本(即情感痛苦的非伤害者和非情感痛苦的非伤害者)。长期目标是产生关于NSSI中情绪失调的来源和性质的更准确的知识，以指导治疗的设计和实施。公共卫生相关性：在青少年和年轻人中，NSSI的发病率高得不成比例。除了辩证行为疗法(DBT)，这是一种针对患有边缘人格障碍的自伤者的强化治疗计划，通常是住院患者，目前还没有针对自伤的治疗方法。该项目代表了在NSSI中产生临床上有用的情绪失调模型以指导有效干预措施发展的程序性研究路线的第一步。