Translational Approaches to the Study of Emotion in Self-Injury

自伤情绪研究的转化方法

基本信息

批准号：
8070428
负责人：
Catherine Rose Glenn
金额：
$ 0.11万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2011-07-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8070428
关键词：
Accounting Adolescent Affect Affective Arousal Aversive Stimulus Behavior Blinking Borderline Personality Disorder Child Control Groups DSM-V Data Development Diagnostic Dialectical behavior therapy Disease Distress Emotional Emotions Etiology Feeling Frequencies Goals Health Image Impairment Individual Informal Social Control Inpatients International Knowledge Laboratories Laboratory Study Manuals Measures Modeling Nature Patient Self-Report Physiological Prevention Process Protocols documentation Proxy Psychological reinforcement Psychophysiology Public Health Punishment Recovery Reflex action Reporting Research Role Sampling Science Self-Injurious Behavior Societies Source Stimulus Study Section Sum Time Tissues base design effective intervention emotion regulation emotional experience emotional reaction emotional stimulus improved indexing injured non-suicidal self injury peer response suicidal translational approach treatment program young adult

项目摘要

DESCRIPTION (provided by applicant): Non-suicidal self-injury (NSSI) describes the deliberate and direct injuring of body tissue without suicidal intent for purposes not socially sanctioned (International Society for the Study of Self-injury; ISSS). Converging evidence suggests that the most common function of NSSI is to regulate negative emotional experiences (e.g., to stop bad feelings). In fact, self-injurers report more frequent and intense negative emotions, a reduction in negative emotions following a self-injurious act, and more emotion dysregulation than non-injurers. Taken together, research suggests that NSSI serves an emotion regulation function for individuals who struggle to regulate emotion. Therefore, careful examination of emotion dysregulation in NSSI could substantially improve knowledge about etiology, prevention, and treatment. Thus far, most of what we know about emotion in NSSI is based on self-report studies, which arguably provide only a crude understanding of emotional deficits. Research guided by an affective science framework could provide more nuanced and clinically useful information about emotion in NSSI. Specifically, emotion can be separated into multiple components, each of which represents a potential source of impairment in disorders characterized by emotion dysregulation. The present study will apply this framework to the study of emotion in NSSI by employing the eyeblink startle reflex, a well-validated physiological measure used to study emotional processing. More specifically, two possible sources of emotion dysregulation will be examined: the magnitude of the startle reflex will be measured 1) during the presentation of emotional and neutral pictures (i.e., to index emotional reactivity) and 2) several seconds following the presentation of these stimuli (i.e., to index return to emotional baseline). The time-course of emotional recovery following aversive stimuli will be further examined in a second study. The study protocol will be administered to a self-injuring and two non-injuring control samples (i.e., affectively distressed non-injurers and non-affectively distressed non-injurers).The long-term goal is to generate more precise knowledge regarding the source and nature of emotional dysregulation in NSSI that can guide the design and implementation of treatments. PUBLIC HEALTH RELEVANCE: Rates of NSSI are disproportionately high in adolescents and young adults. Other than Dialectical Behavior Therapy (DBT), which is an intensive, most often inpatient, treatment program for self-injurers with borderline personality disorder, there is currently no treatment for self-injury. This project represents the first step in a programmatic line of research to generate clinically useful models of emotion dysregulation in NSSI to guide the development of effective interventions.

描述（由申请人提供）：非自杀的自我伤害（NSSI）描述了没有自杀意图的无自杀意图的故意和直接伤害未经社会认可的目的（国际自我伤害研究学会； ISS）。融合的证据表明，NSSI最常见的功能是调节负面的情绪经历（例如，阻止不良情绪）。实际上，自我伤害者报告了比非互动者更频繁和强烈的负面情绪，减少负面情绪的减少以及情绪失调。综上所述，研究表明，NSSI为努力调节情绪的个体发挥了情感调节功能。因此，仔细检查NSSI中的情绪失调可以大大提高对病因，预防和治疗的知识。到目前为止，我们对NSSI中情绪的了解的大多数基于自我报告研究，这可以说仅提供对情绪缺陷的粗略理解。以情感科学框架为指导的研究可以提供有关NSSI情绪的更细微和临床上有用的信息。具体而言，情绪可以分为多个组成部分，每个组成部分代表了以情绪失调为特征的疾病中潜在的损害来源。本研究将通过采用Eykeblink惊吓反射（一种用于研究情绪处理的精心验证的生理方法），将此框架应用于NSSI的情绪研究。更具体地说，将检查两个可能的情绪失调来源：惊吓反射的大小将测量1）在表现出情绪和中性图片（即，以索引情感反应性）和2）呈现这些刺激后的几秒钟（即，以返回情绪基线）。在第二项研究中将进一步研究厌恶刺激后的情绪恢复的时间顺序。该研究方案将用于自我伤害和两个非侵害对照样本（即，有情遇难的非伤害者和非相互痛苦的非伤害者）。长期目标是对NSSI中情绪失调的源和性质的更精确的知识，从而指导治疗的设计和实施。公共卫生相关性：青少年和年轻人的NSSI率不成比例。除了辩证行为疗法（DBT）以外，这是针对具有边缘性人格障碍的自我伤害者的密集，最常见的治疗计划，目前尚无治疗自我伤害的治疗方法。该项目代表了一项计划的研究线中的第一步，该研究线在NSSI中产生临床上有用的情绪失调模型，以指导有效的干预措施的发展。