Neighborhood Characteristics and Diabetes Incidence in the Multiethnic Cohort Stu

多民族队列研究中的社区特征和糖尿病发病率

• 批准号: 8024269
• 负责人: KA'IMI ALOHILANI SINCLAIR
• 金额: $ 11.16万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8024269
• 关键词: Neighborhood; Characteristics; Diabetes; Incidence; Multiethnic

DESCRIPTION (provided by applicant): Candidate. The overarching goal of this Mentored Career Development Award (K01) is to provide Dr. Sinclair with the skills and experience to establish an independent program of diabetes-related disparities research. This career development award is grounded in a multilevel population health conceptual framework that merges advanced didactic instruction with individualized one-on-one mentorship. The advanced research training will serve to catalyze Dr. Sinclair's work, which focuses on unexplored contextual factors that contribute to diabetes prevalence and incidence. This award will provide her with time and salary support to develop an educational foundation and research program that broadens her capabilities to carry out multilevel health disparities research. To build this foundation, the training program consists of three core components: 1) formal coursework in epidemiology, biostatistics, Geographic Information Systems (GIS) technology, spatial analysis, and health disparities research, 2) mentored research training in multilevel modeling and GIS, and 3) instruction in the responsible conduct of research. Dr. Sinclair brings together an interdisciplinary mentorship board that offers extensive research experience and support of her career development program. The K01 award will allow her to benefit from a rich, multidisciplinary mentorship and training environment, which includes experts in epidemiology, biostatistics, GIS, diabetes, and health disparities research. Research Project. Dr. Sinclair proposes to empirically examine the spatial patterning and distribution of diabetes risk factors, prevalence and incidence among the Multiethnic Cohort Study participants by combining individual- and area-level data. The Multiethnic Cohort Study includes a diverse population-based sample of more than 100,000 Hawaiian residents, identified in 1993-1996, who have been followed for more than 15 years. In the proposed project, Dr. Sinclair will geocode the residential addresses of study participants at the time of entry into the cohort. Neighborhood socioeconomic status will be defined from the 1990 U.S. Census. Similarly, measures of neighborhood resources for physical activity and access to healthy foods will be defined. Research aims are to: 1) determine the cross-sectional association between neighborhood characteristics and the prevalence of diabetes and individual-level risk factors for diabetes, including obesity, poor diet, and low levels of physical activity, 2) assess the longitudinal association between neighborhood characteristics and the incidence of diabetes after adjustment for individual-level diabetes risk factors, and 3) examine if the association between neighborhood characteristics and diabetes prevalence and incidence differs by race and ethnicity. The use of a multilevel perspective can help to identify factors associated with diabetes-related disparities, and is congruent with the NIH strategic plan to move the country toward health equity. Findings from this study will illuminate the larger social and economic forces that create differences in health between neighborhoods, and identify geographical areas where traditional and novel public health interventions may best be targeted. The K01 award is critical to Dr. Sinclair's future as a diabetes researcher and will provide her with the time, mentorship, research skills, analytical training, and practical research experience to develop into an independently funded investigator in diabetes prevention and control among health disparate populations. Environment. The University of Hawaii at Manoa is a major education and research facility that serves as the center for research and advanced graduate and professional studies. The UH School of Medicine houses the largest biomedical research facility in Hawaii, and is the most culturally and ethnically diverse medical school in the U.S. Housed within the medical school is the Department of Native Hawaiian Health where Dr. Sinclair is a member of the research faculty. Laurence N. Kolonel, MD, PhD, will serve as Dr. Sinclair's primary mentor. Dr. Kolonel is a Professor at the UH Cancer Research Center and Principal Investigator of the Multiethnic Cohort Study from which Dr. Sinclair will draw her research project. The Cancer Research Center is an NCI- designated cancer center and receives funding from a Cancer Center Support Grant. The Center's mission is to reduce the burden of cancer through research, education, and service with an emphasis on the unique ethnic, cultural, and environmental characteristics of Hawaii and the Pacific. There are currently three cohort studies in the Epidemiology Program, including the Multiethnic Cohort Study. A GIS workgroup, of which Dr. Sinclair is a member, was recently formed to examine contextual factors and cancer incidence. There are several shared resources of the Cancer Center including the Hawaii Tumor registry which is a member of NCI's SEER Program; biostatistics which provides support for study design and data analysis; nutrition support which provides expertise in dietary questionnaire development and maintains extensive food and supplement composition databases; an analytical laboratory capable of analyzing biospecimens and foods for a wide array of constituents; a genomics laboratory which supports studies of genetic susceptibilities and whole-genome expression; and a bioinformatics group which supports the management and analysis of large and complex datasets. While the research activities of the faculty are varied, they are thematically related to the focus on ethnic diversity. 2 PUBLIC HEALTH RELEVANCE: The NIDDK Mentored Research Scientist Development Award will allow for additional training and mentorship that will position Dr. Sinclair to become an independent investigator. She will need protected time to acquire the comprehensive training in health disparities research and multilevel modeling. Dr. Sinclair's proposed research is may aid in efforts to understand and address the persistent problem of inequalities in health from a multilevel perspective. The proposed research has the potential to move our current understanding of contextual/environmental factors and diabetes forward.

描述（由申请人提供）：候选人。该导师职业发展奖 (K01) 的总体目标是为 Sinclair 博士提供建立糖尿病相关差异研究独立项目的技能和经验。该职业发展奖以多层次的人口健康概念框架为基础，将先进的教学指导与个性化的一对一指导相结合。高级研究培训将有助于促进辛克莱博士的工作，其重点是导致糖尿病患病率和发病率的未探索的背景因素。该奖项将为她提供时间和工资支持，以发展教育基金会和研究项目，从而扩大她开展多层次健康差异研究的能力。为了奠定这一基础，培训计划由三个核心组成部分组成：1) 流行病学、生物统计学、地理信息系统 (GIS) 技术、空间分析和健康差异研究的正式课程，2) 多层次建模和 GIS 方面的指导研究培训，以及 3) 负责任的研究行为指导。辛克莱博士组建了一个跨学科导师委员会，为她的职业发展计划提供丰富的研究经验和支持。 K01 奖将使她受益于丰富的多学科指导和培训环境，其中包括流行病学、生物统计学、GIS、糖尿病和健康差异研究方面的专家。研究项目。辛克莱博士建议通过结合个人和地区层面的数据，对多种族队列研究参与者中糖尿病危险因素、患病率和发病率的空间模式和分布进行实证研究。多种族队列研究包括 1993 年至 1996 年间确定的超过 100,000 名夏威夷居民的不同人群样本，并对这些居民进行了超过 15 年的跟踪调查。在拟议的项目中，辛克莱博士将对研究参与者进入队列时的居住地址进行地理编码。社区的社会经济地位将根据 1990 年美国人口普查确定。同样，还将定义用于体育活动和获取健康食品的社区资源的衡量标准。研究目的是：1) 确定邻里特征与糖尿病患病率以及个人层面糖尿病风险因素（包括肥胖、不良饮食和低水平体力活动）之间的横断面关联；2) 在调整个人层面糖尿病风险因素后评估邻里特征与糖尿病发病率之间的纵向关联；3) 检查邻里特征与糖尿病患病率和发病率之间是否存在关联 因种族和民族而异。使用多层次视角可以帮助确定与糖尿病相关的差异相关的因素，并且与 NIH 推动国家实现健康公平的战略计划一致。这项研究的结果将阐明造成社区之间健康差异的更大的社会和经济力量，并确定传统和新型公共卫生干预措施最有针对性的地理区域。 K01 奖对于 Sinclair 博士作为一名糖尿病研究人员的未来至关重要，将为她提供时间、指导、研究技能、分析培训和实践研究经验，以发展成为一名独立资助的研究人员，从事健康不同人群的糖尿病预防和控制。环境。夏威夷大学马诺阿分校是一所主要的教育和研究机构，是研究和高级研究生及专业研究的中心。夏威夷大学医学院拥有夏威夷最大的生物医学研究设施，也是美国文化和种族最多元化的医学院。医学院内设有夏威夷原住民健康部，辛克莱博士是该部的研究人员。医学博士、哲学博士 Laurence N. Kolonel 将担任 Sinclair 博士的主要导师。 Kolonel 博士是夏威夷大学癌症研究中心的教授，也是多种族队列研究的首席研究员，Sinclair 博士将从该研究中得出她的研究项目。癌症研究中心是 NCI 指定的癌症中心，并接受癌症中心支持补助金的资助。该中心的使命是通过研究、教育和服务减轻癌症负担，重点关注夏威夷和太平洋地区独特的种族、文化和环境特征。目前流行病学计划中有三项队列研究，包括多种族队列研究。 Sinclair 博士是一个 GIS 工作组的成员，最近成立了该工作组来检查背景因素和癌症发病率。癌症中心有多个共享资源，包括夏威夷肿瘤登记处（NCI SEER 计划成员）；生物统计学为研究设计和数据分析提供支持；营养支持，提供膳食调查问卷开发方面的专业知识，并维护广泛的食品和补充剂成分数据库；能够分析生物样本和食品中多种成分的分析实验室；支持遗传易感性和全基因组表达研究的基因组学实验室；以及一个支持管理和分析大型复杂数据集的生物信息学小组。虽然教师的研究活动多种多样，但它们的主题都与对种族多样性的关注有关。 2 公共健康相关性：NIDDK 指导研究科学家发展奖将允许额外的培训和指导，使 Sinclair 博士成为一名独立研究者。她将需要受保护的时间来获得健康差异研究和多层次建模方面的全面培训。辛克莱博士提出的研究可能有助于从多层次的角度理解和解决持续存在的健康不平等问题。拟议的研究有可能推动我们目前对背景/环境因素和糖尿病的理解。