Miniature Deep Thermal Imager for Continuous Monitoring of BAT Metabolism

用于连续监测 BAT 代谢的微型深层热成像仪

• 批准号: 8324550
• 负责人: Paolo Francesco Maccarini
• 金额: $ 19.12万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324550
• 关键词: Address; Adhesives; Affect; Back; Bandage; Brown Fat; Caliber; Clinical Research; Communication; Consumption; Coupling; Development; Devices; Diabetes Mellitus; Electromagnetics; Electronics; Energy Metabolism; Goals; Grant; Heating; Hour; Human; Human Activities; Human body; Image; Intervention; Investigation; Lead; Link; Measurement; Measures; Mediating; Medical; Metabolic; Metabolism; Methods; Modeling; Modification; Monitor; Obesity; Organ; Outcome; Outcomes Research; Pain; Painless; Patients; Pattern; Performance; Pharmaceutical Preparations; Play; Positron-Emission Tomography; Power Sources; Preparation; Process; Production; Radiation; Radiometry; Research; Role; Side; Skin; Stimulus; Surface; System; Techniques; Technology; Telemetry; Temperature; Testing; Thermogenesis; Thermometry; Time; Tissues; Toxic effect; Translating; Weight Gain; Wireless Technology; cost; design; detector; energy balance; insulin sensitivity; microwave electromagnetic radiation; miniaturize; new technology; novel strategies; sensor; tissue phantom; tool

DESCRIPTION (provided by applicant): The long term goal of this research is to create a miniature bandage-size non-invasive deep tissue thermal sensor that is sensitive to changes in tissue temperature at depth in the body. The objective of this project is to develop a low cost and harmless new tool for long term monitoring of metabolic activity of human brown adipose tissue (BAT). The rationale for undertaking this development is that there is currently no effective and reliable method for continuous monitoring of energy expenditure of a distributed organ like Brown Adipose Tissue (BAT) which is present in small multifocal depots. We intend to accomplish our objective by pursuing the following three specific aims: Aim 1: Design and fabricate a miniature radiometric sensor suitable for non-invasive measurement of thermal irregularities within 4 cm of the tissue surface. This sensor will require development of: 1.1) appropriate anatomical, thermal and electromagnetic models of BAT, 1.2) low profile microwave antenna with effective coupling to typical BAT regions, and 1.3) low power consumption integrated chip electronics (e.g. HEMT preamplifier, power detector, ultralow loss MEM switch, precision A/D converter). Aim 2: Integrate all components optimized in Aim 1 into an adhesive bandage-size patch sensor including radiometer circuitry, EMI shielding, battery power source, and wireless telemetry link. This miniaturized multichip circuit mounted on the back side ground plane of the receive antenna will require optimization of power consumption, thermal stability, and wireless communication for remote recording of temperature change over long time periods (hours to days) Aim 3: Characterize performance of microwave radiometric sensor in terms of sensing volume, accuracy and stability of temperature measurements, EMI rejection, and error free telemetry. Quantify antenna radiation patterns of the monitoring and telemetry antennas, and quantify temperature sensitivity of the multiband radiometer as functions of target size and depth in tissue and difference above core temperature in multilayer BAT phantoms - in preparation for subsequent use in humans. The expected outcome is a lightweight, adhesive bandage encased, safe and painless thermal monitoring sensor useful for clinical studies requiring long term characterization of energy production or utilization in tissue. The resulting technology should translate readily to thermal monitoring applications beyond this grant.

描述（由申请人提供）：本研究的长期目标是创建一种微型绷带大小的非侵入性深部组织热传感器，该传感器对体内深部组织温度的变化敏感。本项目的目标是开发一种低成本和无害的新工具，用于长期监测人类棕色脂肪组织（BAT）的代谢活动。进行该开发的基本原理是，目前没有有效和可靠的方法来连续监测分布式器官（如棕色脂肪组织（BAT））的能量消耗，棕色脂肪组织存在于小型多灶性贮库中。我们打算实现我们的目标，追求以下三个具体目标：目标1：设计和制造一个微型辐射传感器，适用于非侵入性测量的热不规则性在4厘米的组织表面。该传感器将需要开发：1.1）BAT的适当解剖学、热和电磁模型，1.2）与典型BAT区域有效耦合的低剖面微波天线，以及1.3）低功耗集成芯片电子器件（例如HEMT三极管、功率检测器、超低损耗MEM开关、精密A/D转换器）。目标二：将Aim 1中优化的所有组件集成到胶带大小的贴片传感器中，包括辐射计电路、EMI屏蔽、电池电源和无线遥测链路。这种小型化的多芯片电路安装在接收天线的背面接地层上，将需要优化功耗、热稳定性和无线通信，以远程记录长时间（数小时至数天）的温度变化。目标3：表征微波辐射传感器在感测体积、温度测量的准确性和稳定性、EMI抑制和无误差遥测方面的性能。量化监测和遥测天线的天线辐射模式，并量化多波段辐射计的温度灵敏度，作为目标尺寸和组织深度的函数，以及多层BAT幻影中核心温度以上的差异-为随后在人类中使用做准备。预期的结果是一个重量轻，绷带包裹，安全和无痛的热监测传感器，用于临床研究需要长期表征的能量产生或利用组织。由此产生的技术应该很容易转化为热监测应用超出了这个赠款。

项目成果

Study of the one dimensional and transient bioheat transfer equation: multi-layer solution development and applications.

一维瞬态生物传热方程的研究：多层解的开发和应用。

• DOI: 10.1016/j.ijheatmasstransfer.2012.11.082
• 发表时间: 2013
• 期刊: International journal of heat and mass transfer
• 影响因子: 5.2
• 作者: Rodrigues,DB;Pereira,PJS;Limão-Vieira,P;Stauffer,PR;Maccarini,PF
• 通讯作者: Maccarini,PF

Design of Small-sized and Low-cost Front End to Medical Microwave Radiometer.

小型低成本医用微波辐射计前端设计。

• 发表时间: 2010
• 期刊: Progress in Electromagnetics Research Symposium : [proceedings]. Progress in Electromagnetics Research Symposium
• 作者: Klemetsen,O;Birkelund,Y;Maccarini,PF;Stauffer,P;Jacobsen,SK
• 通讯作者: Jacobsen,SK

Thermal dosimetry for bladder hyperthermia treatment. An overview.

用于膀胱热疗的热剂量测定。

• DOI: 10.3109/02656736.2016.1156170
• 发表时间: 2016
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Schooneveldt,Gerben;Bakker,Akke;Balidemaj,Edmond;Chopra,Rajiv;Crezee,Johannes;Geijsen,ElisabethD;Hartmann,Josefin;Hulshof,MaartenCCM;Kok,HPetra;Paulides,MargarethusM;Sousa-Escandon,Alejandro;Stauffer,PaulR;Maccarini,PaoloF
• 通讯作者: Maccarini,PaoloF

Physics of Thermal Therapy: Fundamentals and Clinical Applications

热疗物理学：基础知识和临床应用

• DOI: 10.1118/1.4804052
• 发表时间: 2013
• 期刊: Medical Physics
• 影响因子: 3.8
• 作者: P. Stauffer

Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism.

人体组织传热数值 3D 建模，用于微波辐射监测棕色脂肪代谢。

• DOI: 10.1117/12.2004931
• 发表时间: 2013
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Rodrigues,DarioB;Maccarini,PaoloF;Salahi,Sara;Colebeck,Erin;Topsakal,Erdem;Pereira,PedroJS;Limão-Vieira,Paulo;Stauffer,PaulR
• 通讯作者: Stauffer,PaulR