2012 Bioelectrochemistry Gordon Research Conference & Gordon Research Seminar

描述(由申请人提供)：本提案请求部分支持将于2012年6月30日至7月6日在意大利巴尔加举行的戈登研究会议和戈登生物电化学研究研讨会。会议的主题是“身体的电动”。会议的广泛目标是从对电场中复合膜的详细了解到通过电化学、基因电转移以及伤口愈合和诊断应用而激动人心的新临床应用之间划清界限。本次会议的具体目的是召集38位代表电场/组织相互作用研究前沿的跨学科演讲者和讨论领袖，与总共140名与会者在9个重点会议期间进行深入讨论。作为一个特别的特点，预计将举行戈登研究研讨会，让年轻研究人员在实际戈登会议开始前24小时内会面并展示他们的成果。预计将有50名博士后研究员、临床研究员和博士生参加此次研讨会。会议将以一个强大的演讲者团队开始，讨论细胞膜和电场之间的相互作用，因为它们与细胞发育有关。接下来的课程包括关于探头和传感器开发的课程，以跟踪电场对细胞和组织的影响。随后的课程将重点介绍外加电场及其在 基因和药物传递。参与基于电穿孔疗法(如电化疗和基因电转移)的临床试验的研究人员和医生小组将从基础科学到实际临床应用的讨论架起桥梁。最后，关于弱电场功能的新的和令人兴奋的数据将导致对它们的讨论 用于诊断和治疗癌症、伤口愈合和其他疾病。 与公共卫生相关：过去30年来，该会议的重点是膜、细胞和生物体与电场的相互作用，特别关注那些参与疾病诊断和治疗的人，包括癌症、肺、神经、遗传疾病和慢性伤口。在高压电场中，细胞可以发生通透性，这可以用来向细胞加载化疗或DNA，而在弱电场中，细胞可能会对定向信号做出反应，这可以用于伤口愈合。通过强调涉及工程、化学、材料科学、成像、细胞生物学、生理学和医学的多学科研究揭示的基本机制，在促进自由和开放的思想交流的氛围中，会议希望加快药物疗法和其他干预措施的优化设计，以减轻这些疾病状态给国家公共卫生带来的负担。

DESCRIPTION (provided by applicant): This proposal requests partial support for the Gordon Research Conference and Gordon Research Seminar on Bioelectrochemistry to be held in Barga, Italy between June 30 to July 6, 2012. The meeting theme is "The body electric". The broad goal of the conference is to draw a direct line from a detailed understanding of the complex membrane in the electric field to exciting new clinical applications with electrochemotherapy, gene electrotransfer, as well as wound healing and diagnostic applications. The specific aim of this meeting is to convene 38 cross-disciplinary speakers and discussion leaders representing the forefront of research into electric field/tissue interactions with a total of 140 participants for in depth discussions during 9 focused sessions. As a particular feature, a Gordon Research Seminar, intended for young researchers to meet and present their results in the 24 hours before the actual Gordon Conference starts, is envisaged. A total of 50 postdoctoral fellows, clinical fellows, and Ph.D. students are anticipated to attend th seminar. The conference will commence with a strong team of speakers discussing interactions between the cell membrane and electric fields as they pertain to cellular development. Sessions to follow include those on probe and sensor development to follow consequences of electric fields on cells and tissues. Subsequent sessions focus on applied electric fields and their use for gene and drug delivery. A panel of researchers and doctors involved in clinical trials on electroporation based therapies (such as electrochemotherapy and gene electrotransfer) will bridge the discussion from basic science to actual clinical application. Finally, new and exciting data on the understanding of the function of weak electric fields will lead to discussions on their use for diagnostic purposes and in the treatment of cancer, in wound healing, and other diseases. PUBLIC HEALTH RELEVANCE: The Conference, ongoing for the past 30 years, focuses on the interactions of membranes, cells, and organisms with electric fields, with a special interest i those involved in diagnosis and treatment of disease, including cancer, pulmonary, neural, genetic disorders, and chronic wounds. In high voltage fields, cell permeabilization can occur which can be used to load cells with chemotherapy or DNA, whereas in weak electric fields, cells may respond to directional cues and this can be used in wound healing. By emphasizing basic mechanisms revealed by multidisciplinary studies involving engineering, chemistry, materials science, imaging, cell biology, physiology, and medicine, in an atmosphere fostering the free and open exchange of ideas, the Conference hopes to accelerate optimal design of drug therapies and other interventions to ease the burden these disease states place on the nation's public health.