2014 Bacterial Cell Surfaces Gordon Research Conference

描述（由申请人提供）：本提案寻求对第21届戈登细菌细胞表面研究会议的支持，该会议将于2014年6月22日至27日在佛蒙特州西多佛的雪山度假村举行。会议的重点是细菌包膜和表面的生物起源，结构和功能，包括细菌膜，细胞壁，表面附属物和聚合物。本次会议提出了一个多样化的主题，模型系统和方法相结合的生物化学，分子遗传学，结构生物学，生物物理学，成像和建模计划。将有9个会议的主题涉及1）细胞壁生物发生，2）表面聚合物，胞外多糖及其分泌，3）细胞区室化和蛋白质定位，4）运动，表面结构和接触依赖的细胞间活动，5）蛋白质分泌，6）细胞分裂和形态发生，7）包膜应激反应，8）内外膜生物发生，和9）穿过细胞被膜的运输。本次会议的目标是：1）通过汇集方法，专业知识，实验模型和资历方面的不同科学家群体，展示这些领域最新和最令人兴奋的研究; 2）产生新的想法，并促进这一不同研究人员群体之间的知识交流;和3）为研究生和博士后研究员提供机会，以简短的谈话或 海报格式，并与该领域的领导人互动。戈登研究会议的传统形式，与程序化的讨论会和下午和晚上的非正式聚会的机会，传达了一个合议的氛围，与会者之间的互动很容易实现。虽然提出的科学是基本的性质，这个多方面的会议的主题是实际利益的生物医学界在 致病机理、抗生素作用和耐药性以及宿主-微生物相互作用等领域，因为这些现象中的许多涉及膜、细胞壁和细胞表面水平的过程。因此，本次会议将为疫苗和抗菌策略的未来发展提供一个平台。

DESCRIPTION (provided by applicant): This proposal seeks support for the 21st Gordon Research Conference on Bacterial Cell Surfaces, which will be held June 22-27, 2014 at Mount Snow Resort, West Dover, VT. The meeting focuses on the biogenesis, structure and function of bacterial envelopes and surfaces, including bacterial membranes, cell walls, and surface appendages and polymers. This conference presents a diverse program in topics, model systems, and approaches combining biochemistry, molecular genetics, structural biology, biophysics, imaging and modeling. There will be 9 sessions on topics related to 1) cell wall biogenesis, 2) surface polymers, exopolysaccharides and their secretion, 3) cell compartmentalization and protein localization, 4) motility, surface structures and contact-dependent intercellular activities, 5) protein secretion, 6) cell division and morphogenesis, 7) envelope stress responses, 8) inner and outer membrane biogenesis, and 9) transport across the cell envelope. The objectives of this conference are to: 1) present the latest and most exciting research in these areas by bringing together a diverse group of scientists with respect to approaches, expertise, experimental model, and seniority; 2) generate new ideas and stimulate intellectual exchange between this diverse group of investigators; and 3) provide opportunities for graduate students and postdoctoral fellows to present their work in short-talk or poster format and to interact with leaders in the field. The traditional format of the Gordon Research Conferences, with programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, conveys a collegial atmosphere where interactions between attendees are easily attained. Although the science presented is basic in nature, the topics of this multifaceted conference are of practical interest to the biomedical community in the areas of pathogenesis, antibiotic action and resistance, and host-microbe interactions, as many of these phenomena involve processes at the level of membranes, cell walls and cell surface. This conference will thus provide a platform for future developments of vaccine and antibacterial strategies.