2014 Bacterial Cell Surfaces Gordon Research Conference

描述(由申请人提供)：本提案寻求对第21届戈登细菌细胞表面研究会议的支持，该会议将于2014年6月22日至27日在佛蒙特州西多佛市雪山度假村举行。会议重点讨论细菌包膜和表面的生物发生、结构和功能，包括细菌膜、细胞壁和表面附件和聚合物。这次会议提出了一个不同的计划，在主题，模型系统，和方法结合生物化学，分子遗传学，结构生物学，生物物理学，成像和建模。将举行9场会议，主题涉及1)细胞壁生物发生，2)表面聚合物，胞外多糖及其分泌，3)细胞区划和蛋白质定位，4)运动，表面结构和接触依赖的细胞间活动，5)蛋白质分泌，6)细胞分裂和形态发生，7)被膜胁迫反应，8)内膜和外膜生物形成，以及9)跨细胞膜运输。这次会议的目的是：1)通过聚集不同的科学家在方法、专业知识、实验模型和资历方面展示这些领域的最新和最令人兴奋的研究；2)产生新的想法并促进这不同的研究人员之间的智力交流；3)为研究生和博士后研究员提供机会，以简短的谈话或 海报格式，并与该领域的领导人互动。戈登研究会议的传统形式是按程序安排讨论会议，并在下午和晚上提供非正式聚会的机会，传达出一种与会者之间很容易实现互动的大学氛围。虽然所介绍的科学本质上是基础的，但这次多方面会议的主题对生物医学社区具有实际意义 在发病机制、抗生素作用和耐药性以及宿主-微生物相互作用等领域，这些现象中的许多涉及膜、细胞壁和细胞表面的过程。因此，这次会议将为疫苗和抗菌策略的未来发展提供一个平台。

DESCRIPTION (provided by applicant): This proposal seeks support for the 21st Gordon Research Conference on Bacterial Cell Surfaces, which will be held June 22-27, 2014 at Mount Snow Resort, West Dover, VT. The meeting focuses on the biogenesis, structure and function of bacterial envelopes and surfaces, including bacterial membranes, cell walls, and surface appendages and polymers. This conference presents a diverse program in topics, model systems, and approaches combining biochemistry, molecular genetics, structural biology, biophysics, imaging and modeling. There will be 9 sessions on topics related to 1) cell wall biogenesis, 2) surface polymers, exopolysaccharides and their secretion, 3) cell compartmentalization and protein localization, 4) motility, surface structures and contact-dependent intercellular activities, 5) protein secretion, 6) cell division and morphogenesis, 7) envelope stress responses, 8) inner and outer membrane biogenesis, and 9) transport across the cell envelope. The objectives of this conference are to: 1) present the latest and most exciting research in these areas by bringing together a diverse group of scientists with respect to approaches, expertise, experimental model, and seniority; 2) generate new ideas and stimulate intellectual exchange between this diverse group of investigators; and 3) provide opportunities for graduate students and postdoctoral fellows to present their work in short-talk or poster format and to interact with leaders in the field. The traditional format of the Gordon Research Conferences, with programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, conveys a collegial atmosphere where interactions between attendees are easily attained. Although the science presented is basic in nature, the topics of this multifaceted conference are of practical interest to the biomedical community in the areas of pathogenesis, antibiotic action and resistance, and host-microbe interactions, as many of these phenomena involve processes at the level of membranes, cell walls and cell surface. This conference will thus provide a platform for future developments of vaccine and antibacterial strategies.