Membranous Nanogenerators for in vivo Bio-mechanical Energy Harvesting

用于体内生物机械能量收集的膜纳米发电机

• 批准号: 9418602
• 负责人: Xudong Wang
• 金额: $ 33.3万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9418602
• 关键词: Adhesions; Agitation; Animal Model; Animals; Area; Articulation; Binding; Biological; Biomechanics; Blood Circulation; Cardiac; Cardiac Surgery procedures; Charge; Chemicals; Cicatrix; Clinical; Corrosion; Data; Development; Devices; Dimensions; Disease model; Energy-Generating Resources; Engineering; Environment; Feedback; Future; Growth; Harvest; Health; Heart; Human body; Implant; Inflammation; Life; Limb structure; Liquid substance; Mechanics; Membrane; Methods; Modulus; Monitor; Morphology; Mus; Muscle; Nanostructures; Nanotechnology; Operative Surgical Procedures; Organ; Output; Pacemakers; Performance; Physicians; Physiology; Polymers; Porifera; Power Sources; Property; Rattus; Research; Research Personnel; Resistance; Respiration; Respiratory Diaphragm; Running; Safety; Savings; Scientist; Series; Stretching; Surface; Surgeon; Surgical sutures; System; Technology; Time; Tissues; Ultrasonics; Weight; Work; absorption; biocompatible polymer; biological systems; biomaterial compatibility; chemical property; density; design; energy density; experience; flexibility; imaging study; implantable device; implantation; improved; in vivo; in vivo evaluation; in vivo imaging; infancy; innovation; insight; light weight; limb movement; mechanical properties; medical specialties; nano; nanomaterials; nanoscale; novel; novel strategies; operation; polyvinylidene fluoride; pressure; public health relevance; success

 DESCRIPTION: Self-powered implantable biomedical devices that provide continuous, real-time sensing, monitoring, and various other vital health functions will only be possible through the development of novel power sources that can harvest energy from the implant's surroundings, in vivo. A variety of energy sources in the human body such as limb articulation, respiration, and heartbeat can provide sufficient power for small biomedical devices. However, the development of in vivo energy harvesting devices into useful electrical power is still in infancy. In this project, we propose to explore innovative nanotechnology to develop ultrathin, lightweight, stretchable and bio-compatible piezoelectric polymer membranes with tunable modulus that can efficiently and discreetly convert the nano-/microscale mechanical energy found in human body to electrical energy, and thereby realize a self-sufficient power supply for implantable biomedical devices. This project builds on the PI (Wang)'s recent development of flexible nanogenerator (NG) - a novel approach for effectively converting mechanical energy into electric energy using polymeric piezoelectric nanomaterials. The Co-I (Cai) has >10 years of experience with in vivo imaging studies and surgical procedures in small animals. The Co-I Dr. Kohmoto specializes in all areas of clinical cardiac surgery and cardiac physiology, and will oversee and perform the advanced surgical procedures needed in the proposed work. Together they form a synergistic team with complementary expertise to design, investigate, and optimize the proposed implantable NGs both ex vivo and in vivo. In Specific Aim 1, we will fabricate flexible membranes from polyvinylidene fluoride (PVDF) with a sponge-like internal mesoporosity. The pore dimension and density will be controlled to engineer the membrane's mechanical and piezoelectric properties, and thus to maximize the mechanical energy absorption and conversion. In Specific Aim 2, we will investigate and optimize the morphology-related capability of harvesting bio-mechanical energy in simulated in vivo conditions. The encapsulation material and electric circuit will be studied to minimize the stray current from NGs. In Specific Aim 3, we will improve the long-term stability of NG membrane on muscle/tissue surfaces via a series of strategies such as scar tissue growth, suture- and pin hole-assisted attachment. The static and dynamic adhesion stability, as well as the as well as potential inflammation and biofouling issues will be investigated and optimized. In Specific Aim 4, the morphology-related capability of harvesting bio-mechanical energy from limb movement, heartbeat, and diaphragm expansion will be studied in vivo using mice or rats. This research will overcome the yet insurmountable challenges of fabricating biocompatible piezoelectric polymer nanostructures and establish a new capability of extracting useful electrical energy from the human body while resulting in minimal impact on the organ's normal functions. The success of this project will make significant contribution to the advancement of the power components of current life-saving implantable devices by reducing the size, lowering the energy density, minimizing the protection package, and resolving safety concerns of the battery systems.

 描述：只有通过开发能够从体内植入物周围环境获取能量的新型电源，才能提供连续、实时传感、监测和各种其他重要健康功能的自供电植入式生物医学设备。人体的肢体关节、呼吸、心跳等多种能源可以为小型生物医学设备提供充足的动力。然而，将体内能量收集装置转化为有用电力的发展仍处于起步阶段。在这个项目中，我们建议探索创新的纳米技术，开发超薄、轻质、可拉伸和生物相容性可调模量的压电聚合物膜，能够高效、谨慎地将人体中的纳米/微米级机械能转化为电能，从而实现植入式生物医学设备的自给自足电源。该项目以 PI（Wang）最近开发的柔性纳米发电机（NG）为基础，这是一种利用聚合物压电纳米材料有效地将机械能转化为电能的新方法。 Co-I (Cai) 在小动物体内成像研究和外科手术方面拥有超过 10 年的经验。 Co-I Kohmoto 博士专门研究临床心脏手术和心脏生理学的所有领域，并将监督和执行拟议工作中所需的高级外科手术。他们共同组成了一个具有互补专业知识的协同团队，以设计、研究和优化所提出的离体和体内植入式 NG。在具体目标 1 中，我们将用聚偏二氟乙烯 (PVDF) 制造具有海绵状内部介孔的柔性膜。控制孔隙尺寸和密度，以设计膜的机械和压电性能，从而最大限度地提高机械能的吸收和转换。在具体目标 2 中，我们将研究并优化在模拟体内条件下收集生物机械能的形态相关能力。我们将对封装材料和电路进行研究，以尽量减少 NG 的杂散电流。 在具体目标3中，我们将通过疤痕组织生长、缝合和针孔辅助附着等一系列策略来提高肌肉/组织表面NG膜的长期稳定性。将研究和优化静态和动态粘附稳定性以及潜在的炎症和生物污垢问题。在具体目标 4 中，将使用小鼠或大鼠在体内研究从肢体运动、心跳和膈肌扩张中收集生物机械能量的形态相关能力。这项研究将克服制造生物相容性压电聚合物纳米结构的难以克服的挑战，并建立一种从人体提取有用电能的新能力，同时对器官正常功能的影响最小。该项目的成功将通过减小尺寸、降低能量密度、最小化保护封装以及解决电池系统的安全问题，为当前救生植入设备的电源组件的进步做出重大贡献。