Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

用于心内起搏器的纳米发电机驱动的自持续电源

• 批准号: 10534064
• 负责人: Xudong Wang
• 金额: $ 7.42万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534064
• 关键词: 3-Dimensional; 3D Print; Academy; Architecture; Area; Atomic Force Microscopy; Biomechanics; Development; Devices; Diamond; Doctor of Philosophy; Educational process of instructing; Educational workshop; Engineering; Faculty; Film; Future Teacher; Goals; Harvest; Location; Measurement; Mechanics; Mentors; Modulus; Morphologic artifacts; Morphology; NCI Scholars Program; Output; Pacemakers; Phase; Positioning Attribute; Postdoctoral Fellow; Power Sources; Property; Readiness; Research; Research Activity; Resolution; Scanning Probe Microscopy; Slide; Stress; Surface; Testing; Training; Underrepresented Minority; Universities; base; career; design; doctoral student; experience; flexibility; improved; materials science; mechanical behavior; mechanical energy; mechanical properties; member; novel; parent grant; pressure; programs; response

This underrepresented minority (URM) supplement project is proposed for the PhD support for Corey Carlos with a research focus on atomic force microscopy (AFM) study of the mechanical and piezoelectric properties of flexible piezoelectric microstructures, and further improve his professional readiness toward his next academic career step. This research activity represents a logical extension of the fundamental goals outlined in the parent grant (R01HL157077). Specifically, this project explores an alternative approach toward intracardiac mechanical energy harvesting, aimed by the parent grant. While the parent grant focuses on using a sliding mode triboelectric nanogenerator design, this supplemental project will examine a new type of electromechanical materials that may serve as an alternative and promising material candidate for achieving intracardiac energy harvesting. The goal of this supplement project is therefore to test a 3D-printed piezoelectric microlattice that can offer designed mechanical flexibility and strong piezoelectric output under small pressure fluctuations. This study will provide an additional set of novel material options for the design of intracardiac biomechanical energy harvesters. This research goal will be achieved through two specific aims. In specific Aim 1, flexible piezoelectric films with microlattices will be fabricated by 3D printing using a novel piezoelectric composite, which can yield desired structural integrity and well-aligned piezoelectric phase. AFM will be used to characterize the localized mechanical property, and establish a relationship between the microstructure and flexibility to reveal the strain distribution when the microlattice is under pressure. In specific Aim 2, the local piezoelectric property from the microlattice will be characterized by the AFM-based piezoelectric force microscopy (PFM) mode, and correlate to the mechanical behaviors at different locations of the microlattice. Combining these characterization results, we will achieve synergistic optimization of mechanical and piezoelectric properties satisfying the requirements of flexible implantable nanogenerator devices. In the URM supplement project, Mr. Corey Carlos will perform the basic 3D print fabrication and carry out all the proposed AFM-based characterization under the mentoring of PI Wang. This supplement project offers an excellent opportunity for Corey to establish more experiences on soft bio-related materials characterizations and development. It will also help Corey to extend his research portfolio to the areas of biomedical materials and devices – an extremely promising direction that he wants to build his academic career. In the supplement project, Corey will also participate multiple teaching and output programs, including the First Year Faculty Teaching Academy (FYFTA), the WiscProf: Future Faculty in Engineering Workshop, and the Graduate Engineering Research Scholars (GERS) program.

这个代表不足的少数民族(URM)补充项目是为科里·卡洛斯的博士支持提出的， 原子力显微镜(AFM)研究材料的力学和压电性能 灵活的压电微结构，并进一步提高他的职业准备，为他的下一个学术 事业上的进步。这项研究活动代表了家长概述的基本目标的合乎逻辑的延伸 格兰特(R01HL157077)。具体地说，这个项目探索了一种替代心内机械治疗的方法。 能源采集，由父母拨款的目标。而父母资助的重点是使用滑动模式摩擦电动 纳米发电机的设计，这个补充项目将研究一种新型的机电材料， 可作为实现心内能量采集的一种替代材料和有前景的材料。这个 因此，本补充项目的目标是测试一种3D打印的压电微晶格，该微晶格可以提供设计的 机械灵活性好，压力波动小，压电输出能力强。这项研究将提供 另一套用于设计心内生物机械能量采集器的新材料选项。这 研究目标将通过两个具体目标来实现。在具体目标1中，柔性压电薄膜 微晶格将通过3D打印制造，使用一种新型的压电复合材料，可以产生所需的 结构完整，压电相排列良好。AFM将被用来表征本地化的 力学性能，并建立微观结构和柔韧性之间的关系，以揭示应变 微晶格受压时的分布。在具体目标2中，局部压电性能来自 微晶格将通过基于AFM的压电力显微镜(PFM)模式进行表征，并与 微晶格不同位置的力学行为。结合这些表征结果， 我们将实现满足要求的机械性能和压电性能的协同优化 灵活的可植入纳米发电机设备。在市建局补充计划中，科里·卡洛斯先生将表演 基本的3D打印制作，并在PI的指导下执行所有提出的基于AFM的表征 王。这个补充项目为Corey提供了一个极好的机会，让他在软件方面建立更多的经验 生物相关材料的表征与发展。它还将帮助科里扩大他的研究组合 到生物医学材料和设备领域--这是一个非常有希望的方向，他想要建立他的 学术生涯。在补充项目中，科里还将参与多个教学和产出项目， 包括第一年学院教学学院(FYFTA)，WiscProf：未来工程学学院 和研究生工程研究学者(GERS)计划。