Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

用于心内起搏器的纳米发电机驱动的自持续电源

• 批准号: 10534064
• 负责人: Xudong Wang
• 金额: $ 7.42万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534064
• 关键词: 3-Dimensional; 3D Print; Academy; Architecture; Area; Atomic Force Microscopy; Biomechanics; Development; Devices; Diamond; Doctor of Philosophy; Educational process of instructing; Educational workshop; Engineering; Faculty; Film; Future Teacher; Goals; Harvest; Location; Measurement; Mechanics; Mentors; Modulus; Morphologic artifacts; Morphology; NCI Scholars Program; Output; Pacemakers; Phase; Positioning Attribute; Postdoctoral Fellow; Power Sources; Property; Readiness; Research; Research Activity; Resolution; Scanning Probe Microscopy; Slide; Stress; Surface; Testing; Training; Underrepresented Minority; Universities; base; career; design; doctoral student; experience; flexibility; improved; materials science; mechanical behavior; mechanical energy; mechanical properties; member; novel; parent grant; pressure; programs; response

This underrepresented minority (URM) supplement project is proposed for the PhD support for Corey Carlos with a research focus on atomic force microscopy (AFM) study of the mechanical and piezoelectric properties of flexible piezoelectric microstructures, and further improve his professional readiness toward his next academic career step. This research activity represents a logical extension of the fundamental goals outlined in the parent grant (R01HL157077). Specifically, this project explores an alternative approach toward intracardiac mechanical energy harvesting, aimed by the parent grant. While the parent grant focuses on using a sliding mode triboelectric nanogenerator design, this supplemental project will examine a new type of electromechanical materials that may serve as an alternative and promising material candidate for achieving intracardiac energy harvesting. The goal of this supplement project is therefore to test a 3D-printed piezoelectric microlattice that can offer designed mechanical flexibility and strong piezoelectric output under small pressure fluctuations. This study will provide an additional set of novel material options for the design of intracardiac biomechanical energy harvesters. This research goal will be achieved through two specific aims. In specific Aim 1, flexible piezoelectric films with microlattices will be fabricated by 3D printing using a novel piezoelectric composite, which can yield desired structural integrity and well-aligned piezoelectric phase. AFM will be used to characterize the localized mechanical property, and establish a relationship between the microstructure and flexibility to reveal the strain distribution when the microlattice is under pressure. In specific Aim 2, the local piezoelectric property from the microlattice will be characterized by the AFM-based piezoelectric force microscopy (PFM) mode, and correlate to the mechanical behaviors at different locations of the microlattice. Combining these characterization results, we will achieve synergistic optimization of mechanical and piezoelectric properties satisfying the requirements of flexible implantable nanogenerator devices. In the URM supplement project, Mr. Corey Carlos will perform the basic 3D print fabrication and carry out all the proposed AFM-based characterization under the mentoring of PI Wang. This supplement project offers an excellent opportunity for Corey to establish more experiences on soft bio-related materials characterizations and development. It will also help Corey to extend his research portfolio to the areas of biomedical materials and devices – an extremely promising direction that he wants to build his academic career. In the supplement project, Corey will also participate multiple teaching and output programs, including the First Year Faculty Teaching Academy (FYFTA), the WiscProf: Future Faculty in Engineering Workshop, and the Graduate Engineering Research Scholars (GERS) program.

这个代表性不足的少数民族（URM）补充项目是为博士支持科里卡洛斯与 一个研究重点是原子力显微镜（AFM）的机械和压电性能的研究， 柔性压电微结构，并进一步提高他的专业准备，他的下一个学术 职业阶梯这项研究活动代表了一个合乎逻辑的延伸的基本目标概述了在家长 赠款（R 01 HL 157077）。具体来说，该项目探索了一种替代方法， 能量收集，由家长资助。虽然父母补助金的重点是使用滑动模式摩擦电 纳米发电机设计，这个补充项目将研究一种新型的机电材料， 可以作为实现心内能量收集的替代和有前景的材料候选物。的 因此，这个补充项目的目标是测试3D打印的压电微晶格，可以提供设计的 机械柔性和在小压力波动下的强压电输出。本研究将提供 用于设计心内生物力学能量采集器的额外一组新型材料选项。这 研究目标将通过两个具体目标来实现。在具体的目标1中，制备了柔性压电膜， 微晶格将使用新型压电复合材料通过3D打印制造，该复合材料可以产生所需的 结构完整性和良好排列压电相。原子力显微镜将用于表征本地化的 力学性能，并建立微观结构和柔性之间的关系，以揭示应变 当微晶格处于压力下时的分布。在具体的目标2中，来自压电晶体的局部压电性质被确定为压电晶体的压电特性。 微晶格将通过基于AFM的压电力显微镜（PFM）模式来表征，并关联 在微晶格的不同位置处的机械行为。结合这些表征结果， 我们将实现满足要求的机械和压电性能的协同优化 柔性可植入纳米发电机设备。在URM补充项目中，Corey卡洛斯先生将执行 基本的3D打印制造，并在PI的指导下进行所有拟议的基于AFM的表征 王.这个补充项目提供了一个很好的机会，科里建立更多的经验，软 生物相关材料的表征和开发。这也将有助于科里扩大他的研究组合 到生物医学材料和设备领域-一个非常有前途的方向，他想建立他的 学术生涯。在补充项目中，Corey还将参与多个教学和输出项目， 包括第一年的教师教学学院（FYFTA），WiscProf：未来的工程学院 研讨会和研究生工程研究学者（GERS）计划。