Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

用于心内起搏器的纳米发电机驱动的自持续电源

• 批准号: 10415097
• 负责人: Xudong Wang
• 金额: $ 68.65万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415097
• 关键词: Address; Adsorption; Animals; Biology; Biomechanics; Blood; Cardiac; Cardiac Surgery procedures; Cardiovascular system; Charge; Clinical; Coagulation Process; Data; Development; Device Designs; Devices; Elastomers; Electricity; Electrodes; Electronics; Engineering; Ensure; Environment; Evaluation; Evolution; Family suidae; Fibrin; Frequencies; Future; Harvest; Heart; Hemostatic Agents; Implant; Location; Membrane; Modeling; Monitor; Motion; Muscle; Operative Surgical Procedures; Organ; Output; Pacemakers; Physiological; Power Sources; Proteins; Research; Right ventricular structure; Safety; Site; Source; Stretching; Surface; Surgeon; Surgical sutures; System; Techniques; Technology; Testing; Thrombelastography; Thrombosis; Time; Tissues; Work; biomaterial compatibility; clinically relevant; design; flexibility; heart function; implantation; improved; in vivo; in vivo evaluation; innovation; mechanical properties; microelectronics; miniaturize; multidisciplinary; nanoscale; next generation; novel; operation; porcine model; pressure; prevent; success; voltage

Project Summary: Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project is led by Dr. Wang (PI), with Drs. Hacker and Liu as the co-Is and a cardiac surgeon Dr. Osaki as collaborator, for the development of a flexible i-NG to harvest energy from biomechanical sources. Previous work from Wang and Hacker has confirmed the long-term stability of i-NGs and their negligible impacts on normal heart functions when sutured on swine hearts. Wang has also developed a flexible, micro-grating i-NG capable of converting slow organ motion to continuous alternating current (AC) electricity desired for efficient capacitor charging. Building on these supportive preliminary results, this project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. In Specific Aim 1, we will develop a stretchable SSPS that integrates a flexible i-NG with a commercial supercapacitor and regulating electronics. The membrane i-NG can convert heart beats into continuous, high-frequency AC electricity with an output voltage suitable for efficiently charging the supercapacitor. In Specific Aim 2, we will investigate the bio- and hemo-compatibility of SSPS ex vivo and test the SSPS device in a simulated intracardiac environment. In Specific Aim 3, we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The ability to power a commercial pacemaker will also be tested in vivo. In Specific Aim 4, we will investigate intracardiac implantation of SSPS on the internal RV free wall of a surgically removed and beating swine heart on a Langendroff apparatus to test the intracardiac operation ex vivo. This proposed research will develop a novel intracardiac energy harvester that is self-sustainable by harvesting biomechanical energy from heartbeats. Success of this research will establish a technology framework necessary to move rapidly to in vivo intracardiac implantation and testing of SSPS for powering intracardiac pacemakers . This intracardiac energy harvesting technique will present an unprecedented engineering solution to address the power supply challenges for the next generation intracardiac pacemakers by altering flexibility, decreasing size, improving safety, and eliminating the battery component.

项目摘要： 起搏器的革命进步包括一个微型且无铅的设计和心脏内部 植入。但是，笨重和僵硬的电池为进一步发展而产生了最大的障碍 可以连接并符合组织和肌肉表面的系统，而不会引起不必要的生理 更改。为了应对这一关键挑战，该项目建议开发自我维持的电源 （SSP）用于使用猪模型的心脏内起搏器。 SSP集成了可拉伸的频率调节 具有微型超级电容器和调节电子设备的植入纳米发育仪（I-NG），可以 通过从心跳中收集能量来自动，始终如一地为起搏器供电。 该项目由博士（PI）博士领导。黑客和刘（Co-IS）和心脏外科医生奥崎氏（Dr. Osaki） 合作者，开发灵活的I-NG，从生物力学来源收集能量。以前的工作 Wang和Hacker已经确认了I-NG的长期稳定性及其对正常心脏功能的影响不佳 当缝合在猪心上时。王还开发了一种灵活的微粒i-ng，能够转换慢 器官运动需要为有效电容器充电而进行连续交流电流（AC）电力。建立 这些支持性的初步结果，该项目着重于设计和验证专门用于供电的SSP 心脏心脏起搏器通过从心跳中收集能量。在特定目标1中，我们将开发可拉伸的SSP 这将灵活的I-NG与商业超级电容器和调节电子设备相结合。膜I-NG可以 将心脏跳动转换为连续的高频AC电力，其输出电压适合有效 为超级电容器充电。在特定目标2中，我们将研究SSP的Ex Vivo的生物和血液兼容性 并在模拟心脏内环境中测试SSP设备。在特定的目标3中，我们将表征电气 SSP的体内在右心外膜表面的不同位置和方向上的体内输出 （RV）猪心。随着时间的流逝，将监测心脏功能，以确保SSP植入不会改变心脏 功能。商业起搏器的动力能力也将在体内进行测试。在特定目标4中，我们将调查 SSP的心脏内植入在外科手术的内部无RV壁上，并在 Langendroff设备测试了体内的心脏内操作。 这项拟议的研究将开发出一种新颖的心内能量收割机，可以通过收获来自我维持 心跳产生的生物力学能量。这项研究的成功将建立一个必要的技术框架 快速移动到体内室内植入和SSP的测试，以为心脏内起搏器供电。这 心脏内能量收集技术将提出前所未有的工程解决方案，以解决能力 通过改变灵活性，减小尺寸，改善 安全，并消除电池组件。