Autonomic Rare Diseases Clinical Research Consortium - Datamining Supplement

自主神经罕见疾病临床研究联盟 - 数据挖掘增刊

基本信息

  • 批准号:
    9718979
  • 负责人:
  • 金额:
    $ 6.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-08-15 至 2020-06-30
  • 项目状态:
    已结题

项目摘要

SUMMARY This application is being submitted in response to NOT-TR-18-019. Our goal is to use the existing dataset of patients enrolled in the Natural History Study of the Synucleinopathies, Project 1 of the Autonomic Rare Diseases Consortium, to explore the potential contribution of supine hypertension to the morbidity and mortality of patients with synucleinopathies. Our ultimate goal is to improve survival of patients with synucleinopathies, which are progressive neurodegenerative disorders caused by the abnormal accumulation of misfolded α- synuclein (αSyn) in the nervous system. Neurodegeneration of the autonomic nervous system causing cardiovascular autonomic dysfunction is a characteristic feature of patients with synucleinopathies. While a sustained fall in blood pressure on standing (i.e., neurogenic orthostatic hypotension, nOH) is their most commonly recognized feature, approximately 50% of patients with autonomic failure also have hypertension in the supine position. Because nOH and supine hypertension occur concomitantly in the same patient, their consequences are difficult to disentangle. nOH has immediate, short-term consequences such as syncope and falls, but it has also been associated with long-term renal, cardiac, and cerebrovascular complications was well as premature death. However, these studies did not account for the presence of supine hypertension as a potential confounder and hypertension is strongly associated with renal, cardiac and cerebral damage, as well as increased mortality. Therefore, the extent to which the results of previous studies of patients with hypertension apply to those with supine hypertension and nOH is unclear. Our HYPOTHESIS is that supine hypertension in patients with autonomic synucleinopathies increases the risk of end-target organ damage and negatively impacts survival in these patients. Our OBJECTIVE is use the existing dataset of patients enrolled in the Natural History Study of the Synucleinopathies (Project 1 of the Autonomic Rare Diseases Consortium) to determine whether supine hypertension contributes to morbidity and premature mortality of patients with synucleinopathies. Our AIMS are: ONE. To determine if supine hypertension is associated with increased burden of end-target organ damage in patients with synucleinopathies. And TWO: To define if supine hypertension increases the risk of major cardiovascular events and mortality in patients with synucleinopathies. It is conceivable that excess mortality in patients with synucleinopathies is not only due to the neurodegenerative process but, perhaps, also due to supine hypertension. If our hypothesis results to be correct, implementation of clinical studies for the prevention and treatment of supine hypertension in patients with synucleinopathies will be warranted.
总结

项目成果

期刊论文数量(110)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations.
  • DOI:
    10.1097/j.pain.0000000000002475
  • 发表时间:
    2022-06-01
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Kleykamp BA;Dworkin RH;Turk DC;Bhagwagar Z;Cowan P;Eccleston C;Ellenberg SS;Evans SR;Farrar JT;Freeman RL;Garrison LP;Gewandter JS;Goli V;Iyengar S;Jadad AR;Jensen MP;Junor R;Katz NP;Kesslak JP;Kopecky EA;Lissin D;Markman JD;McDermott MP;Mease PJ;O'Connor AB;Patel KV;Raja SN;Rowbotham MC;Sampaio C;Singh JA;Steigerwald I;Strand V;Tive LA;Tobias J;Wasan AD;Wilson HD
  • 通讯作者:
    Wilson HD
The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension.
  • DOI:
    10.1007/s00415-016-8375-x
  • 发表时间:
    2017-08
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Gibbons CH;Schmidt P;Biaggioni I;Frazier-Mills C;Freeman R;Isaacson S;Karabin B;Kuritzky L;Lew M;Low P;Mehdirad A;Raj SR;Vernino S;Kaufmann H
  • 通讯作者:
    Kaufmann H
Dexmedetomidine for refractory adrenergic crisis in familial dysautonomia.
Autonomic disorders predicting Parkinson's disease.
  • DOI:
    10.1016/s1353-8020(13)70024-5
  • 发表时间:
    2014-01
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Palma, Jose-Alberto;Kaufmann, Horacio
  • 通讯作者:
    Kaufmann, Horacio
Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response?
  • DOI:
    10.1113/ep085340
  • 发表时间:
    2015-11-01
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Mora, Cristina Fuente;Norcliffe-Kaufmann, Lucy;Kaufmann, Horacio
  • 通讯作者:
    Kaufmann, Horacio
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Italo Biaggioni其他文献

Italo Biaggioni的其他文献

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{{ truncateString('Italo Biaggioni', 18)}}的其他基金

Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic Hypotension
气道正压通气治疗仰卧位高血压和改善神经源性直立性低血压的血流动力学效应
  • 批准号:
    10532156
  • 财政年份:
    2021
  • 资助金额:
    $ 6.92万
  • 项目类别:
Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic Hypotension
气道正压通气治疗仰卧位高血压和改善神经源性直立性低血压的血流动力学效应
  • 批准号:
    10344947
  • 财政年份:
    2021
  • 资助金额:
    $ 6.92万
  • 项目类别:
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
肥胖心血管和代谢改变中的交感机制
  • 批准号:
    10417218
  • 财政年份:
    2019
  • 资助金额:
    $ 6.92万
  • 项目类别:
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
肥胖心血管和代谢改变中的交感机制
  • 批准号:
    10619649
  • 财政年份:
    2019
  • 资助金额:
    $ 6.92万
  • 项目类别:
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
肥胖心血管和代谢改变中的交感机制
  • 批准号:
    10192815
  • 财政年份:
    2019
  • 资助金额:
    $ 6.92万
  • 项目类别:
Splanchnic Circulation and Blood Pressure Regulation
内脏循环和血压调节
  • 批准号:
    9542936
  • 财政年份:
    2017
  • 资助金额:
    $ 6.92万
  • 项目类别:
Splanchnic Circulation and Blood Pressure Regulation
内脏循环和血压调节
  • 批准号:
    9253102
  • 财政年份:
    2015
  • 资助金额:
    $ 6.92万
  • 项目类别:
CLINICAL CORE
临床核心
  • 批准号:
    8147955
  • 财政年份:
    2010
  • 资助金额:
    $ 6.92万
  • 项目类别:
CARDIOVASCULAR REGUATIONS: AUTONOMIC/METBOLIC MECHANISMS
心血管调节:自主/代谢机制
  • 批准号:
    8147951
  • 财政年份:
    2010
  • 资助金额:
    $ 6.92万
  • 项目类别:
project 2 - Autonomic Rare Diseases Clinical Research Consortium
项目 2 - 自主神经罕见疾病临床研究联盟
  • 批准号:
    7901211
  • 财政年份:
    2009
  • 资助金额:
    $ 6.92万
  • 项目类别:

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Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity
久坐时间对超重/肥胖青少年心脏自主神经系统功能的自由生活和实验室影响
  • 批准号:
    10598404
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    2023
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  • 项目类别:
Assessment of Autonomic Nervous System Function in Post-Acute Sequelae of COVID-19 (PASC) and Characterization of the Patient Experience
COVID-19 急性后遗症 (PASC) 的自主神经系统功能评估和患者体验特征
  • 批准号:
    480723
  • 财政年份:
    2023
  • 资助金额:
    $ 6.92万
  • 项目类别:
Comprehensive research to elucidate the diversity and dispersibility of the autonomic nervous system
阐明自主神经系统多样性和分散性的综合研究
  • 批准号:
    23H00422
  • 财政年份:
    2023
  • 资助金额:
    $ 6.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Relationship of autonomic nervous system function on functional brain networks during normal drinking and abstinence in daily drinkers
日常饮酒者正常饮酒和戒酒时自主神经系统功能与功能性脑网络的关系
  • 批准号:
    10540603
  • 财政年份:
    2022
  • 资助金额:
    $ 6.92万
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The Acute Effects of Cannabis and Cannabinoids on Human Cardiovascular Physiology: Understanding Contributing Mechanisms in the Myocardium, Peripheral Vasculature, and Autonomic Nervous System.
大麻和大麻素对人类心血管生理学的急性影响:了解心肌、外周脉管系统和自主神经系统的贡献机制。
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    548126-2020
  • 财政年份:
    2022
  • 资助金额:
    $ 6.92万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Role of "motivation" neurons in regulating autonomic nervous system function
“动机”神经元在调节自主神经系统功能中的作用
  • 批准号:
    22K19709
  • 财政年份:
    2022
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    $ 6.92万
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    Grant-in-Aid for Challenging Research (Exploratory)
Verification of the effectiveness of neck and shoulder warm compresses in improving stiffness symptoms, psychological symptoms, and autonomic nervous system balance.
验证颈肩部热敷对改善僵硬症状、心理症状和自主神经系统平衡的有效性。
  • 批准号:
    22K17447
  • 财政年份:
    2022
  • 资助金额:
    $ 6.92万
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    Grant-in-Aid for Early-Career Scientists
Autonomic Nervous System Functioning in Heavy Drinking Adolescents: Interactions with sleep, circadian functioning, and health
酗酒青少年的自主神经系统功能:与睡眠、昼夜节律功能和健康的相互作用
  • 批准号:
    10201841
  • 财政年份:
    2021
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    $ 6.92万
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开发创新技术重建自主神经系统概念
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    21K18269
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    2021
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    $ 6.92万
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The Acute Effects of Cannabis and Cannabinoids on Human Cardiovascular Physiology: Understanding Contributing Mechanisms in the Myocardium, Peripheral Vasculature, and Autonomic Nervous System.
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    2021
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