CSHL Protein Homeostasis in Health and Disease Conference

CSHL 健康与疾病中的蛋白质稳态会议

基本信息

批准号：
9470420
负责人：
DAVID J. STEWART
金额：
$ 3.07万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9470420
关键词：
Address Affect Aging Aging-Related Process Alpha Cell Alzheimer&apos s Disease Amino Acids Amyloidosis Animal Model Area Attention Basic Science Binding Biochemical Biogenesis Biology Biomedical Research Biophysics Businesses Cell Compartmentation Cell physiology Cells Characteristics Client Communicable Diseases Communities Complement Complex Data Development Diabetes Mellitus Dimensions Discipline Disease Ensure Environment Equilibrium Explosion Faculty Failure Feedback Financial Support Fire - disasters Fostering Future General Population Goals Health Heart Heart Diseases Heat shock proteins Heat-Shock Response Homeostasis Hormones Huntington Disease In Vitro Industry International Journals Knowledge Laboratories Malignant Neoplasms Measures Metabolic Diseases Metabolism Methods Molecular Molecular Chaperones Nerve Degeneration Neurodegenerative Disorders Oral Organism Parkinson Disease Participant Pathogenicity Pathway interactions Peptide Hydrolases Physiology Play Polymers Postdoctoral Fellow Prion Diseases Process Protein Conformation Proteins Publishing Quality Control Questionnaires Recording of previous events Research Institute Research Personnel Ribosomal Proteins Ribosomes Role Schedule Science Scientist Signal Transduction Slide Stress Thinking Time Toxic effect Translating Work age effect age related cell type disorder risk graduate student healthy aging in vivo insight interest lectures meetings novel polypeptide posters protein aggregation protein degradation protein folding protein function protein misfolding proteostasis repaired response success symposium tumor metabolism virtual

项目摘要

Cold Spring Harbor Laboratory Conference on Protein Homeostasis in Health and Disease April 17 – 21, 2018 ABSTRACT This proposal is a request for financial support for a meeting on PROTEIN HOMEOSTASIS IN HEALTH AND DISEASE to be held at Cold Spring Harbor Laboratory from April 17 – 21, 2018. This meeting is the premier international forum for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the relevance of this process to healthy aging and diseases of neurodegeneration, cancer, and metabolism guarantees an excitement and urgency of this meeting. Because of the recent developments that have identified the ribosome at the origin of protein folding, we will have a new session on this topic and another new session that emphasizes emerging quality control mechanisms. The relationship between synthesis, folding, translocation and degradation will be addressed through sessions on molecular mechanisms of chaperone function, degradative mechanisms and on spatial quality control and organellar proteostasis. These fundamental questions are at the heart of biology and will be complemented by sessions on aging and proteostasis failure, and how this establishes the risk for diseases of protein misfolding including Alzheimer's disease, ALS, Parkinson's disease and Huntington's disease. The themes of aging, proteostasis failure, and diseases of protein misfolding will be integrated throughout the meeting, and emerging principles on protein client interactions and alternate protein conformations will be predominantly displayed. The diverse protein quality control strategies used by compartments of the cell to ensure the integrity of the secretory and organellar pathways during times of protein folding stress will be represented by emerging topics on spatial quality control within a cell. The field of heat shock proteins and molecular chaperones has grown exponentially and draws interest not only from traditional scientific disciplines in the basic sciences but also from diverse areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will have eight lecture sessions, two poster sessions, a rapid-fire presentation session, and a panel discussion on scientific publishing. The proposed sessions include: 1) Proteostasis at the ribosome and protein folding, 2) Chaperone mechanisms I, 3) Novel mechanisms of quality control, 4) Degradation mechanisms, 5) Chaperone mechanisms II, 6) Aging and pathogenic aggregation, 7) Organellar proteostasis and spatial quality control, and 8) Proteostasis failure and disease. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. A maximum of two additional speakers will be pre-invited per session and the remainder will be selected from submitted abstracts. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, and to encourage diverse participation that recognizes new investigators.

冷春港实验室会议蛋白质稳态在健康和疾病中 2018年4月17日至21日抽象的该提案是为蛋白质稳态会议的会议的要求健康和疾病将于2018年4月17日至21日在冷泉港实验室举行。这次会议是在该领域介绍新结果的主要国际论坛，通过代表该领域的每个主要实验室的代表来参加。爆炸有关如何在体内获取和维持蛋白质折叠状态的新信息该过程与神经变性，癌症和代谢保证了这次会议的兴奋和紧迫性。因为最近已经鉴定出蛋白质折叠起源的核糖体的发展，我们将有一个有关此主题的新会议以及另一个强调新兴质量控制的新会议机制。合成，折叠，易位和降解之间的关系将是通过会议解决伴侣功能的分子机制，降解机理和空间质量控制和有机蛋白质的机制。这些基本问题是生物学的核心，将由有关衰老的会议完成蛋白质抑制衰竭，以及如何确定蛋白质疾病错误折叠的风险阿尔茨海默氏病，ALS，帕金森氏病和亨廷顿氏病。衰老的主题，蛋白质衰竭和蛋白质错误折叠疾病将整合到整个过程中蛋白质客户相互作用和替代蛋白质的会议和新兴原则构象将主要显示。多样的蛋白质质量控制策略由细胞隔室使用以确保秘密和细胞器的完整性蛋白质折叠应力时期的途径将由空间上的新兴主题表示单元内的质量控制。热激蛋白和分子伴侣的领域具有成倍成长，不仅从基本的传统科学学科中吸引了兴趣科学以及来自生物医学研究的潜水区域，包括神经退行性疾病，传染病，癌症，心脏病和衰老。会议将有八个演讲会议，两次海报会议，迅速演示会议和小组讨论关于科学出版。拟议的会话包括：1）核糖体处的蛋白质静脉曲张和蛋白质折叠，2）伴侣机制i，3）质量控制的新型机制，4）降解机制，5）伴侣机制II，6）衰老和致病性聚集， 7）细胞器蛋白质和空间质量控制，以及8）蛋白质衰竭和疾病。每个会议将由八到九个口头演讲组成，并由受邀的主持人主持扬声器。每个会话最多将预先提前两个扬声器其余部分将从提交的摘要中选择。这种谈判的平衡使会议得以领先科学家的功能演讲，以应对令人兴奋的新发展，并鼓励潜水员参与认可新研究人员。