Georgia Diabetes Translation Research Center

项目摘要/摘要 在过去的25年里，美国的糖尿病流行已经发生了相当大的变化。值得注意的是， 糖尿病患病率和绝对数的增长远远超过了统计预测， 越来越多的糖尿病患者是少数族裔和低收入人群 社会经济背景、发病和首次诊断似乎比过去几十年更年轻。尽管 糖尿病预防和管理的证据基础已经扩大-随之而来的是，在 护理和控制糖尿病及相关合并症--主要差距依然存在：1)患有糖尿病的人数比例 未确诊的糖尿病和糖尿病前期没有改善；2)对预防的参与度极低；以及 3)年轻人和被剥夺公民权的糖尿病患者在控制方面进展不佳。而且，虽然 “经典”糖尿病并发症，如心肌梗塞、中风和截肢的发生率 在过去的20年里急剧下降，同样，这些下降对年轻人、少数族裔来说不那么令人印象深刻， 和较低的社会经济人口；以及其他糖尿病并发症的增加，如认知 衰弱、抑郁和心力衰竭。因此，似乎患有糖尿病的年轻人将与 生命早期的经典并发症和患有糖尿病的老年美国人将与更多年的身体状况作斗争 和精神残疾。这在数量、复杂性(即， 多种发病率)，以及与糖尿病相关的医疗系统费用。为了应对这些趋势， 美国东南部，那里的糖尿病结果差异特别明显，佐治亚州埃默里大学 理工学院和莫尔豪斯医学院共同提议建立佐治亚州 糖尿病翻译研究中心(GDTRC)。凭借其广泛的专业基础；丰富的联邦-和 基金会资助的项目平台；接触社区、卫生系统、地方和联邦政府；以及 容易获得的工具和技术；GDTRC准备加快糖尿病的开展和使用 东南部的翻译研究。GDTRC提供翻译研究核心(设计和评估； 参与度和行为改变；以及差异)旨在响应关闭剩余的需求 糖尿病检测、预防和护理方面的差距，以及美国糖尿病人口不断变化的概况。 GDTRC将带来创新、合作、多学科、包容性的精神(例如，考虑到 传统的[种族/民族]和新的观点[例如，寿命上的差异；人的不同结果 患有抑郁症或认知能力下降])，并继续学习以促进更多和有用的糖尿病 翻译研究。此外，GDTRC的区域核心、浓缩计划以及试点和可行性 该计划将“扩大馅饼”，并产生意识和需求、与专业人员的链接、工具(例如，开放的 访问资源库)和机会(例如，试点和小额赠款)，并托管在线和面对面平台 与GDTRC及其庞大的资源基础进行接触。

PROJECT SUMMARY/ABSTRACT The diabetes epidemic in the United States (US) has evolved considerably over the last quarter century. Of note, the growth in prevalence and absolute numbers of people with diabetes has far exceeded statistical projections, growing proportions of those affected by diabetes are people of minority race/ethnicities and from lower socioeconomic backgrounds, and onset and first diagnosis appear to be younger than in decades past. Though the evidence base for diabetes prevention and management has grown ‒ and with that, some improvement in care and control of diabetes and associated co-morbidities ‒ major gaps persist: 1) The proportion of people with undiagnosed diabetes and prediabetes has not improved; 2) Engagement in prevention is exceedingly low; and 3) Young adults and disenfranchised populations with diabetes fare poorly in terms of control. And, while incidence rates of “classical” diabetes complications like myocardial infarction, stroke, and amputations have dramatically declined in the last 20 years, again, these declines were less impressive for young adults, minorities, and low socioeconomic populations; and there have been increases in other diabetes complications like cognitive decline, depression, and heart failure. As such, it appears that younger people with diabetes will contend with classical complications earlier in life and older Americans with diabetes will contend with more years of physical and mental disability. This has profound implications for US health care in terms of the volume, complexity (i.e., multi-morbidity) of cases, and health system costs related to diabetes. To address these trends in the Southeastern US, where disparities in diabetes outcomes are particularly apparent, Emory University, Georgia Institute of Technology, and the Morehouse School of Medicine together propose to establish the Georgia Diabetes Translation Research Center (GDTRC). With its broad base of expertise; wealth of federal- and foundation-funded project platforms; access to communities, health systems, local and federal government; and readily-available tools and technologies; the GDTRC is poised to accelerate the conduct and use of diabetes translation research in the Southeast. The GDTRC offers Translation Research Cores (Design and Evaluation; Engagement and Behavior Change; and Disparities) designed to be responsive to the need to close remaining gaps in diabetes detection, prevention, and care, and to the changing profile of the US diabetes population. GDTRC will bring a spirit of innovation, collegiality, multidisciplinarity, inclusivity (e.g., considering disparities from traditional [race/ethnic] and new perspectives [e.g., disparities across the lifespan; disparate outcomes in people with depression or cognitive decline]), and continued learning towards promoting more and useful diabetes translation research. Further, the GDTRC's Regional Core, Enrichment Program, and Pilot and Feasibility Program will “grow the pie” and generate awareness and demand, linkage to expert faculty, tools (e.g., open- access resource library) and opportunities (e.g., pilot and micro grants), and host online and in-person platforms to engage with GDTRC and its base of tremendous resources.