A Cohort for Studying the Burden of Cardiometabolic Diseases in Guam and Pohnpei

项目摘要 美国附属的太平洋群岛(USAPI)的岛民经历了一些最高的死亡率 世界上由非传染性疾病(NCD)引起的比率，但它们被排除在 国家健康调查，如国家健康和营养检查调查和 全国健康访谈调查。缺乏关于人口的纵向健康数据使得 要真正了解他们面临的健康差距和限制他们的能力是极其困难的 以满足他们的长期健康需求。该项目的目的是建立 关岛和关岛的一代流行病学队列，重点是心脏代谢危险因素 波恩佩。大约1100名儿童和父母(或550天)将被招募以获得 来自两代USAPI的非传染性疾病生活方式因素的信息。具体目标是： 1)估计非传染性疾病生活方式因素(文化适应、酒精、槟榔、饮食、 高血压、肥胖、体力活动、睡眠、压力和吸烟)，2)估计 通过生物标志物检测糖尿病(DM)和血脂异常的患病率，以及3)验证 糖尿病与黑棘皮病的关系。孩子们将从早期开始招募 听力和检测干预关岛和波恩佩的出生队列。研究人员将 接受有关人口健康研究的伦理和方法方面的培训。数据收集将 包括调查问卷和收集生物检疫样本，以核实 心脏代谢生物标志物。在整个研究过程中，拟议的伙伴关系 (在关岛大学和密克罗尼西亚学院的方案中，公共卫生 实验室、社区合作伙伴以及政府和非政府机构 数据链接基础设施的形式)，将进一步发展。流行病学队列将是 通过将工作制度化并在合作伙伴之间分担工作来维持。随着时间的推移， 数据将提供关岛和波恩佩心脏代谢风险的关键信息，并将 用于完善健康信息和干预战略，以及改善平等 与USAPI人群相关的卫生保健做法。 1

Project Summary Islanders in the US-Affiliated Pacific Islands (USAPI) experience some of the highest mortality rates resulting from non-communicable diseases (NCD) in the world, yet they are excluded from national health surveys such as the National Health and Nutrition Examination Survey and the National Health Interview Survey. The absence of longitudinal health data on populations makes it extremely difficult to truly understand their health disparities they face and restricts the ability to address their long-term health needs. The intent of this project is to establish the baseline of a generational epidemiologic cohort, with a focus on cardiometabolic risk factors, in Guam and Pohnpei. Approximately 1,100 children and parents (or 550 dayds) will be recruited to obtain information on NCD lifestyle factors from two generations of USAPIs. The specific aims are to: 1) estimate the prevalence of NCD lifestyle factors (acculturation, alcohol, betel nut, diet, hypertension, obesity, physical activity, sleep, stress, and tobacco use), 2) estimate the prevalence diabetes mellitus (DM) and dyslipidemia through biomarkers, and 3) validate the association of DM and acanthosis nigricans. The children will be recruited from the Early Hearing and Detection Intervention birth cohorts in Guam and Pohnpei. The research staff will be trained in the ethics and methods involved in population health research. Data collection will include survey questionnaires and the collection of biospecimens for the verification of cardiometabolic biomarkers. Throughout the research process, the proposed partnerships (among the University of Guam and College of Micronesia programs, the public health laboratories, community partners, and government and non-government agencies with some form of data linkage infrastructure), will be further developed. The epidemiologic cohort will be sustained through the institutionalization and sharing of the work among partners. Over time the data will provide critical information on the cardiometabolic risk in Guam and Pohnpei and will be used to refine health messages and intervention strategies, as well as improve the equality of health care practices relevant to USAPI populations. 1