Neural Bases of Self-regulatory Control in Bulimia Nervosa

神经性贪食症自我调节控制的神经基础

• 批准号: 9392278
• 负责人: Laura A. Berner
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392278
• 关键词: Adult; Affect; Affective; Age; Anterior; Base of the Brain; Behavior; Behavior Control; Behavioral; Binge Eating; Brain; Bulimia; Chronic; Comorbidity; Complement; Controlled Study; Corpus striatum structure; Data; Development; Disease; Down-Regulation; Eating; Eating Disorders; Emotional; Emotions; Equilibrium; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Habits; Impairment; Impulse Control Disorders; Impulsive Behavior; Individual; Informal Social Control; Intervention; Investigation; Link; Matched Group; Measures; Mediating; Medical; Mental disorders; Modeling; Motor; National Institute of Mental Health; National Research Service Awards; Neurocognitive; Operant Conditioning; Participant; Pathology; Patient Self-Report; Pattern; Performance; Prefrontal Cortex; Process; Psychotherapy; Recurrence; Regulation; Reporting; Research; Research Training; Resistance; Sampling; Self-control as a personality trait; Severities; Strategic Planning; Symptoms; Task Performances; Testing; Training; Training Activity; Vomiting; Woman; base; behavior measurement; brain behavior; cingulate cortex; design; emotion regulation; experience; functional disability; improved; interest; loss of control over eating; motor control; negative affect; neural circuit; neurodevelopment; novel; positive emotional state; programs; public health relevance; purge; relating to nervous system; research study; response; skills; therapy development

 DESCRIPTION (provided by applicant): Recent evidence suggests that impairments in self-regulatory control may contribute to the development and persistence of bulimia nervosa (BN). "Loss of control" over eating and compensatory behaviors in BN may result, in part, from deficits in inhibitory control and associated brain-based dysfunction in corticostriatal circuits. In additin, recent models of BN pathology suggest that impairments in self-regulation of emotion may relate to disorder-specific behaviors. Deficits in the ability to exert self-regulatory control may also allow repeated binge eating and purging to become an entrenched behavioral pattern. Identification and characterization of brain-based abnormalities in BN, which could inform novel interventions that target these abnormalities, is imperative. A main objective of the National Institute of Mental Health Strategic Plan includes promoting discovery of brain-behavior processes that contribute to mental illness. Consistent with this strategic objective and the need to develop new and targeted treatments for BN, the proposed Ruth L. Kirschstein National Research Service Award (NRSA) is a three-year program of research and training focused on the overlapping corticostriatal neural circuits mediating multiple self-regulatory capacities in adult BN. Prior studies of control-related deficits in BN have been limited by their use of a singl task to study a single neurocognitive process. The proposed study assesses, among women with BN (n = 30) and group-matched controls (n = 30), the behavioral and neural determinants of three forms of self-regulation (motor inhibition, emotion regulation, and goal-directed action control) and examines relations among these capacities and BN symptoms. The project combines functional magnetic resonance imaging (fMRI), eating disorder symptom assessment, and well-validated neurocognitive tasks. The project aims to test the hypotheses that: 1) women with BN will demonstrate decreased corticostriatal activation and impaired performance during motor inhibitory control and emotion regulation tasks, 2) women with BN will demonstrate deficient goal-directed control abilities, and 3) BN participants with more severe symptoms will demonstrate the greatest impairments in corticostriatal activation, and a model including self-regulatory abilities in all three domains will best predict BN severity. To our knowledge, this project is the first to examine brain activation during negative and positive emotion regulation in BN and the first to investigate a potential relative imbalance in goal-directed control and habit-based responding in BN. This NRSA will lay groundwork for future investigations of the neural substrates of eating disorders by providing the applicant with the advanced skills and research experience needed to collect, analyze, and interpret fMRI and behavioral data, along with introductory training in neurodevelopment. The project's novel integration of multiple, non-symptom-specific probes of motor, affective, and goal-directed behavioral control within the same sample permits distinction of the relative contributions of these self- regulatory control capacities to BN pathology.

 描述（由申请人提供）：最近的证据表明，自我调节控制的损害可能有助于神经性贪食症（BN）的发展和持续。BN的饮食和代偿行为“失控”可能部分是由于皮质纹状体回路抑制性控制和相关脑功能障碍的缺陷。此外，最近的BN病理模型表明，情绪自我调节的损伤可能与疾病特异性行为有关。缺乏自我调节控制的能力可能 也会让反复暴饮暴食和排泄成为一种根深蒂固的行为模式。识别和表征BN中基于大脑的异常，这可以为针对这些异常的新干预提供信息，这是必要的。国家精神卫生研究所战略计划的一个主要目标包括促进发现导致精神疾病的大脑行为过程。根据这一战略目标和开发新的BN靶向治疗方法的需要，提出了Ruth L。Kirschstein国家研究服务奖（NRSA）是一项为期三年的研究和培训计划，重点是成年BN中介导多种自我调节能力的重叠皮质纹状体神经回路。先前对BN中控制相关缺陷的研究受限于他们使用单一任务来研究单一的神经认知过程。拟议的研究评估，BN（n = 30）和组匹配的控制（n = 30），行为和神经的决定因素的三种形式的自我调节（运动抑制，情绪调节，目标导向的行动控制），并检查这些能力和BN症状之间的关系。该项目结合了功能性磁共振成像（fMRI），进食障碍症状评估和经过充分验证的神经认知任务。该项目旨在检验以下假设：1）BN女性将在运动抑制控制和情绪调节任务期间表现出皮质纹状体激活减少和表现受损，2）BN女性将表现出目标导向控制能力不足，3）症状更严重的BN参与者将表现出皮质纹状体激活的最大损伤，并且包括所有三个领域中的自我调节能力的模型将最好地预测BN严重性。据我们所知，这个项目是第一个研究大脑激活过程中的消极和积极的情绪调节， BN和第一个调查潜在的相对不平衡的目标导向的控制和习惯为基础的反应在BN。本NRSA将为申请人提供收集、分析和解释功能磁共振成像和行为数据所需的高级技能和研究经验，并沿着神经发育的入门培训，从而为未来研究进食障碍的神经基础奠定基础。该项目在同一样本中新颖地整合了运动、情感和目标导向行为控制的多种非症状特异性探针，从而可以区分这些自我调节控制能力对BN病理的相对贡献。