Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
基本信息
- 批准号:10214573
- 负责人:
- 金额:$ 49.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-13 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAdolescentAdultAngiographyBloodBlood CirculationBlood VesselsBlood VolumeBlood flowBone MarrowClinical ResearchClinical TrialsClinical Trials DesignCombination immunotherapyCommunitiesCorrosion CastingDoseFemaleFour-dimensionalFractionationFutureGoalsImmune responseImmune systemLaboratory miceLibrariesLymphocyteMale AdolescentsMeasuresMethodologyMethodsModalityModelingMusNatureOrganPatient RepresentativePatientsPopulationRadiationRadiation Dose UnitRadiation InteractionRadiation OncologyRadiation therapyRiskRodentSiteStructureTherapeutic StudiesTimeTreatment Protocolsbasecell killingcortical bonedesigndosimetryex vivo imagingin vivo imaginginnovationirradiationlymph nodeslymphoid organmalemathematical modelmicroCTmouse modelnovelpre-clinical researchpreclinical studyprocess optimizationsimulationskeletaltooltreatment optimizationtreatment planning
项目摘要
Project Abstract / Summary
This proposal will develop methods to quantify the interaction of radiation with the immune system, particularly
the blood (i.e., circulating lymphocytes). We envision that future treatment planning in radiation oncology will
treat lymphatic nodes and the blood as organs at risk and include them in the treatment optimization process
so as to influence the level at which the radiation treatment impacts the immune system of the patient. During
radiation therapy, depletion of circulating lymphocytes originates mainly from (1) immediate cell killing during
irradiation of blood vessels, and thus circulating lymphocytes, within the treatment field and (2) to a lesser
extent, the radiation dose to lymphocytes residing within lymphoid organs that can mobilize their lymphocyte
population upon systemic depletion.
There are currently no whole-body computational phantoms available that can facilitate the calculation of blood
or lymphocyte dose-volume histograms. However, this tool is a prerequisite to the use of bio-mathematical
models for clinical trial design. The phantoms to be developed in this study will be the first to fill this urgent
need for the radiation therapy and research communities. In addition to the overall innovative nature of this
project, several of our methods are novel and have never been employed in our field:
• The first use of tetrahedral mesh structures to model blood vessels (SA1)
• The first implementation of a whole-body compartment model for blood flow (SA2)
• The first four-dimensional modeling of blood flow using vasculature structures (SA3)
• The first model of the mouse vasculature for pre-clinical studies (SA4)
项目摘要/摘要
该提案将开发方法来量化辐射与免疫系统的相互作用,特别是
血液(即,循环淋巴细胞)。我们设想,放射肿瘤学的未来治疗计划将
将淋巴结和血液作为有风险的器官进行治疗,并将其纳入治疗优化过程
从而影响放射治疗影响患者免疫系统的水平。期间
在放射治疗中,循环淋巴细胞的消耗主要源于(1)在放射治疗期间的立即细胞杀伤,
照射治疗区域内的血管,从而照射循环淋巴细胞,以及(2)照射到较小的
程度,对淋巴器官内淋巴细胞的辐射剂量,
人口系统性枯竭。
目前还没有全身计算幻影可用于促进血液的计算
或淋巴细胞剂量-体积直方图。然而,这个工具是使用生物数学的先决条件。
用于临床试验设计的模型。在这项研究中开发的幻影将首先填补这一紧迫的
需要放射治疗和研究社区。除了整体创新的性质,
项目,我们的几种方法是新颖的,从来没有在我们的领域使用:
·首次使用四面体网格结构对血管进行建模(SA 1)
·第一次实现血流的全身隔室模型(SA 2)
·使用脉管系统结构的血流的第一四维建模(SA 3)
·用于临床前研究的第一个小鼠脉管系统模型(SA 4)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WESLEY E BOLCH其他文献
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{{ truncateString('WESLEY E BOLCH', 18)}}的其他基金
Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes
项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件
- 批准号:
10327396 - 财政年份:2022
- 资助金额:
$ 49.05万 - 项目类别:
Project 1: Deployable Software for the Rapid Assessment of Organ Dose Following Radionuclide Intakes
项目 1:用于快速评估放射性核素摄入后器官剂量的可部署软件
- 批准号:
10589871 - 财政年份:2022
- 资助金额:
$ 49.05万 - 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
- 批准号:
10429988 - 财政年份:2020
- 资助金额:
$ 49.05万 - 项目类别:
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
开发用于血液剂量测定的全身计算模型,以模拟辐射对免疫系统的影响
- 批准号:
10655343 - 财政年份:2020
- 资助金额:
$ 49.05万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10200807 - 财政年份:2019
- 资助金额:
$ 49.05万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10456116 - 财政年份:2019
- 资助金额:
$ 49.05万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10696129 - 财政年份:2019
- 资助金额:
$ 49.05万 - 项目类别:
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid Imaging
MIRDCalc — 用于导出和报告核医学、计算机断层扫描和混合成像中患者器官剂量的社区工具
- 批准号:
10017971 - 财政年份:2019
- 资助金额:
$ 49.05万 - 项目类别:
APPLICATION OF MR IMAGING TO THE STUDY OF BONE DOSIMETRY
MR成像在骨剂量研究中的应用
- 批准号:
7182973 - 财政年份:2005
- 资助金额:
$ 49.05万 - 项目类别:
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