Oklahoma Center for Respiratory and Infectious Diseases

项目总结 科布雷二期申请寻求支持，以进一步发展多研究所俄克拉荷马中心 呼吸系统和传染病研究所(OCRID)成为一个可持续的卓越研究中心。已建立 2013年，通过第一阶段科布雷赠款，OCRID迅速成为扩大呼吸系统的焦点 俄克拉何马州的传染病研究。OCRID调查人员来自世界各地的主要研究机构 俄克拉荷马州，包括俄克拉荷马州立大学(OSU)和俄克拉何马大学的10所学院 俄克拉何马州(OU)，以及一个独立的研究机构，俄克拉荷马州医学研究基金会 (OMRF)。OCRID致力于在呼吸系统和传染病方面的研究和培训方面的卓越表现，这是统一的 疾病。我们的科学家和领导层通过深思熟虑的教师指导培养卓越，稳健 跨学科协作、创新研究和动态的从工作台到床边到市场的方法。 作为俄亥俄州立大学有史以来收到的第一笔科布雷奖金，第一阶段奖在 俄克拉荷马州呼吸道传染病研究概况。在成功的基础上 第一阶段奖，这个第二阶段Cobre应用的总体目标是建立一个可持续的研究 呼吸系统和传染病领域的卓越中心。在四项第二期研究计划中， 呼吸道传染病在这一应用中由四名有才华和有前途的初级调查人员领导，两名 重点关注流感病毒，一种是肺炎链球菌，一种是铜绿假单胞菌。目标1将 在呼吸道感染专题领域扩大多学科调查人员的临界人数 疾病。这一目标将通过1)指导四个第二阶段项目负责人成为NIH资助的项目来实现 独立调查人员；2)招聘至少4名新的终身教职跟踪教员，其研究范围在 中心的重点；3)培养初级调查人员，并将现有调查人员重新定向到呼吸系统 通过试点项目进行传染病研究；以及4)招募和指导替代项目 目前的第二阶段项目负责人在最初的2-3年支持后轮换。目标2将 进一步发展研究基础设施，加强三个独特的研究核心(动物模型， 免疫病理学和分子生物学)。AIM 3将加强俄克拉荷马州的机构间合作 建立一个自给自足的呼吸道和传染病研究中心。OCRID VIA的进一步发展 这一第二阶段的COBRE将对#年的呼吸道和传染病研究产生更大的积极影响 俄克拉何马州，并将维持俄克拉荷马州唯一的此类中心。

PROJECT SUMMARY This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from major research institutions across the state of Oklahoma, including 10 colleges at Oklahoma State University (OSU) and the University of Oklahoma (OU), as well as an independent research institute, the Oklahoma Medical Research Foundation (OMRF). OCRID is unified by a commitment to excellence in research and training in respiratory and infectious diseases. Our scientists and leadership cultivate excellence through deliberate faculty mentorship, robust interdisciplinary collaboration, innovative research, and a dynamic bench-to-bedside-to-marketplace approach. As the first CoBRE grant ever received by OSU, the Phase I award has made a transformative change in the research landscape on respiratory infectious disease research in Oklahoma. Building on the success of the Phase I award, the overall objective of this Phase II CoBRE application is to build a sustainable research center of excellence in the field of respiratory and infectious diseases. Of the four Phase II research projects on respiratory infectious diseases in this application led by four talented and promising junior investigators, two focus on influenza virus, one on Streptococcus pneumonia and one on Pseudomonas aeruginosa. Aim 1 will expand the critical mass of multi-disciplinary investigators in the thematic area of respiratory infectious diseases. This aim will be accomplished by 1) mentoring four Phase II project leaders to become NIH-funded independent investigators; 2) hiring at least 4 new tenure-track faculty members whose research is within the focus of the Center; 3) nurturing junior investigators and re-directing established investigators into respiratory infectious disease research via a pilot project program; and 4) recruiting and mentoring replacement project leaders after the current Phase II project leaders rotate out after the initial 2-3 years of support. Aim 2 will further develop the research infrastructure by strengthening three unique research cores (Animal Models, Immunopathology, and Molecular Biology). Aim 3 will enhance inter-institutional collaborations in Oklahoma to develop a self-sustainable respiratory and infectious research center. The further development of OCRID via this Phase II CoBRE will have even greater positive impact on respiratory and infectious disease research in the state of Oklahoma and will sustain the only Center of its kind in Oklahoma.