Oklahoma Center for Respiratory and Infectious Diseases

俄克拉荷马州呼吸和传染病中心

• 批准号: 10215542
• 负责人: LIN LIU
• 金额: $ 223.38万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215542
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Animal Model; Applications Grants; Area; Award; Centers of Research Excellence; Collaborations; Communicable Diseases; Communities; Core Facility; Development; Disease; Faculty; Financial Support; Foundations; Funding; Goals; Grant; Health Sciences; Infectious Diseases Research; Influenza; Institutes; Institution; Journals; Leadership; Lung diseases; Lung infections; Malignant Neoplasms; Medical Research; Medicine; Mentors; Mentorship; Modernization; Molecular Biology; Nature; Oklahoma; Paper; Phase; Pilot Projects; Pneumonia; Population; Positioning Attribute; Program Research Project Grants; Pseudomonas aeruginosa; Publishing; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Respiratory Center; Respiratory Tract Infections; Scientist; Series; Services; Streptococcus pneumoniae; Talents; Technology; United States National Institutes of Health; Universities; Viral; bench to bedside; burden of illness; college; combat; drug development; immunopathology; improved; influenzavirus; innovation; inter-institutional; interdisciplinary collaboration; meetings; member; multidisciplinary; new technology; prevent; programs; public health priorities; recruit; respiratory; success; tenure track

PROJECT SUMMARY This CoBRE Phase II application seeks support to further develop the multi-institute Oklahoma Center for Respiratory and Infectious Diseases (OCRID) into a sustainable center of research excellence. Established in 2013 through the Phase I CoBRE grant, OCRID is quickly becoming a focal point for expanding respiratory infectious disease research in Oklahoma. OCRID investigators come from major research institutions across the state of Oklahoma, including 10 colleges at Oklahoma State University (OSU) and the University of Oklahoma (OU), as well as an independent research institute, the Oklahoma Medical Research Foundation (OMRF). OCRID is unified by a commitment to excellence in research and training in respiratory and infectious diseases. Our scientists and leadership cultivate excellence through deliberate faculty mentorship, robust interdisciplinary collaboration, innovative research, and a dynamic bench-to-bedside-to-marketplace approach. As the first CoBRE grant ever received by OSU, the Phase I award has made a transformative change in the research landscape on respiratory infectious disease research in Oklahoma. Building on the success of the Phase I award, the overall objective of this Phase II CoBRE application is to build a sustainable research center of excellence in the field of respiratory and infectious diseases. Of the four Phase II research projects on respiratory infectious diseases in this application led by four talented and promising junior investigators, two focus on influenza virus, one on Streptococcus pneumonia and one on Pseudomonas aeruginosa. Aim 1 will expand the critical mass of multi-disciplinary investigators in the thematic area of respiratory infectious diseases. This aim will be accomplished by 1) mentoring four Phase II project leaders to become NIH-funded independent investigators; 2) hiring at least 4 new tenure-track faculty members whose research is within the focus of the Center; 3) nurturing junior investigators and re-directing established investigators into respiratory infectious disease research via a pilot project program; and 4) recruiting and mentoring replacement project leaders after the current Phase II project leaders rotate out after the initial 2-3 years of support. Aim 2 will further develop the research infrastructure by strengthening three unique research cores (Animal Models, Immunopathology, and Molecular Biology). Aim 3 will enhance inter-institutional collaborations in Oklahoma to develop a self-sustainable respiratory and infectious research center. The further development of OCRID via this Phase II CoBRE will have even greater positive impact on respiratory and infectious disease research in the state of Oklahoma and will sustain the only Center of its kind in Oklahoma.

项目摘要 此CobRE第二阶段申请寻求支持，以进一步发展多研究所俄克拉荷马州中心 呼吸和传染病（OCRID）成为卓越的可持续研究中心。建立 2013年，通过第一阶段的CoBRE拨款，OCRID正在迅速成为扩大呼吸系统的焦点。 俄克拉荷马州的传染病研究。OCRID的调查人员来自世界各地的主要研究机构， 俄克拉荷马州，包括10所学院在俄克拉荷马州州立大学（OSU）和 俄克拉荷马州（俄克拉荷马州），以及一个独立的研究机构，俄克拉荷马州医学研究基金会 （OMRF）。OCRID致力于呼吸和传染病领域的卓越研究和培训， 疾病我们的科学家和领导通过精心的教师指导培养卓越， 跨学科合作、创新研究以及充满活力的从实验室到临床再到市场的方法。 作为俄勒冈州立大学收到的第一笔Cobre赠款，第一阶段的奖励对 俄克拉荷马州呼吸道传染病研究的研究前景。在联合国成功的基础上， 第一阶段的奖励，这第二阶段的总体目标是建立一个可持续的研究 呼吸道和传染病领域的卓越中心。在四个第二阶段的研究项目中， 呼吸道传染病在这个应用程序中由四个有才华和有前途的初级研究人员领导， 重点是流感病毒，一个是肺炎链球菌，一个是铜绿假单胞菌。目标1将 扩大呼吸道传染病专题领域多学科调查人员的临界数量 疾病这一目标将通过以下方式实现：1）指导四名第二阶段项目负责人成为NIH资助的 独立调查员; 2）雇用至少4名新的终身教职员工，他们的研究在 中心的重点; 3）培养初级研究者，并将已建立的研究者重新定向到呼吸系统 通过试点项目计划进行传染病研究;以及4）招募和指导替代项目 目前的第二阶段项目负责人在最初的2-3年支持后轮换。目标2将 通过加强三个独特的研究核心（动物模型， 免疫病理学和分子生物学）。目标3将加强俄克拉荷马州的机构间合作， 建立一个自我维持的呼吸和传染病研究中心。OCRID的进一步发展， 这个第二阶段的CoBRE将对呼吸道和传染病研究产生更大的积极影响， 俄克拉荷马州，并将维持俄克拉荷马州唯一的同类中心。