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Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of Bone

骨超短回波时间 (UTE) 磁共振成像

基本信息

批准号：
9344532
负责人：
Jiang Du
金额：
$ 41.8万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-17 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9344532
关键词：
Affect Age Biochemical Biochemical Markers Biological Markers Biomechanics Body mass index Bone Density Bone Marrow Cadaver Cattle Clinical Collagen Control Groups Diagnosis Dual-Energy X-Ray Absorptiometry Elderly Ethnic Origin Evaluation Fatty acid glycerol esters Fracture Goals Gold Head and neck structure Human Image Imaging Techniques Isotopes Leg Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Marrow Measurement Measures Medicine Minerals Modeling Monitor NMR Spectroscopy Neck Obesity Osteoporosis Physiologic pulse Play Porosity Postmenopause Premenopause Property Quantitative Evaluations Reference Standards Relaxation Risk Factors Roentgen Rays Role Sampling Scanning Signal Transduction Soft Tissue Disorder Specimen Staging Techniques Testing Therapeutic Time Triglycerides Trochanters Unsaturated Fats Water Woman Work X-Ray Computed Tomography age group base bone bone imaging bone loss bone quality clinical application cohort cortical bone density fracture risk improved in vivo in vivo imaging insight interest mechanical properties millisecond novel osteoporosis with pathological fracture public health relevance quantitative imaging spectroscopic imaging substantia spongiosa temporal measurement two-dimensional

项目摘要

DESCRIPTION (provided by applicant): Quantitative imaging of bone has been of central importance in medicine since Roentgen produced the first radiograph in 1895. The current gold standard technique DEXA measures bone mineral density (BMD). However, the majority of bone, including the organic matrix and bone water which together occupy ~60% of bone by volume is inaccessible. BMD by itself only predicts osteoporotic fractures with an accuracy of 30-50%. The overall fracture risk increases 13-fold from ages 60 to 80, but BMD alone only predicts a doubling of the fracture risk. In addition, recent studies demonstrate that bone marrow adiposity plays an active role in affecting bone quantity and quality. There is considerable interest in more comprehensive evaluation of bone quality using information not only about bone mineral, but organic matrix, bone water and marrow fat. All of these factors may play a role in maintaining the biomechanical integrity of cortical and trabecular bone. Magnetic resonance imaging (MRI) is routinely used in the diagnosis of soft tissue disease. However, bone is "invisible" using all clinical sequences due to its short T2*. We have developed 2D and 3D UTE sequences with TEs of 8 µs that are ~1000 times shorter than conventional TEs. This makes it possible to detect multiple water components in cortical bone, and fat content and composition in trabecular bone. The pore water content provides a surrogate measure of cortical porosity. Collagen-bound water provides an indirect measure of organic matrix density. Marrow fat content and composition provide BMD independent fracture risk factors. It would be a major advance to develop UTE MRI techniques to evaluate porosity and organic matrix density in cortical bone, as well as marrow fat content and composition in trabecular bone. This study aims to develop and combine novel 3D UTE MRI techniques to evaluate cortical and trabecular bone offering full insight into bone characterization and correlation with function. To achieve thi goal, in Aim 1 we will evaluate 3D UTE MRI techniques for assessment of cortical bone. We will determine the accuracy of UTE measurement of collagen-bound and pore water, and correlate UTE MRI metrics (collagen-bound and pore water content, T1, T2* and MTR) with biomechanical properties of cortical bone. In Aim 2 we will evaluate 3D UTE MRI techniques for evaluation of trabecular bone. We will determine the accuracy of 3D UTE MRI measurement of marrow fat content and composition and correlate 3D UTE MRI metrics with those from MR spectroscopy (MRS) as well as biomechanical properties of trabecular bone. In Aim 3 we will apply the validated 3D UTE MRI techniques to study one group of premenopausal women and two groups of postmenopausal women with slow or fast bone loss. We will compare the 3D UTE MRI and MRS metrics in different groups and correlate the results with BMD and biochemical markers. This work will provide accurate panels of 3D UTE MRI and MRS based biomarkers which may be important for assessing bone quality, and may have a major impact on the diagnosis and therapeutic monitoring of OP.