BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

骨代谢的生化参数——年龄和性别对比

• 批准号: 3802253
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802253
• 关键词: 1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; aging; biomarker; bone density; bone metabolism; calcium; female; femur; gender difference; hormone regulation /control mechanism; human old age (65+); human subject; longitudinal human study; male; osteocalcin; parathyroid hormones; spine; young adult human (21-34)

Age-related changes in bone mass have been demonstrated in both men and women. A causal role in age-related bone loss has been attributed to alterations in vitamin D status, the bone mineral regulating hormones and/or renal function. it has been hypothesized that compromised vitamin D status and/or circulating levels of the active, hormonal form of the vitamin are a concomitant of aging and are responsible for part of the bone loss seen in the elderly. Studies in the Baltimore Longitudinal Study of Aging have demonstrated that there are no differences across the age span in 25-OHD or 1,25 (OH)2 D levels in normal men or women. Both men and women had an age associated increase in PTH levels that was not independently correlated with creatinine clearance. In order to determine the relationship between these parameters as well as measures of bone turnover (osteocalcin and urinary calcium) to bone mass, bone mineral density (BMD) at three sites (radius, spine and femur) was measured in normal men and women of the BLSA. Serum 25-OHD, 1,25(OH)2 D, and PTH were not related to BMD at any site in young (<48 years) men or old (>60 yrs) women. However, in old men, lower age-adjusted radius BMD was significantly associated with higher PTH and 1,25(OH)2 D and lower 25 OHD values. Young men, who had a cross-sectional decline in femoral BMD comparable to that of old men, had significant associations of high values for the markers of bone turnover with low age-adjusted BMD. These results emphasized the heterogeneity of bone loss and factors associated with it. This heterogeneity is partially dependent on age, gender, and the specific bone site involved.

在男性和女性中， 妇女 与年龄相关的骨丢失的因果作用被归因于 维生素D状态的改变，骨矿物质调节激素 和/或肾功能。 有人假设，受损的维生素 D状态和/或循环水平的活性，激素形式的 维生素是衰老的伴随物， 在老年人中看到的损失。 在巴尔的摩的纵向研究中， 老化表明，在不同年龄段之间没有差异， 25-OHD或1，25（OH）2 D水平。 男性和 女性的PTH水平与年龄相关， 与肌酐清除率独立相关。 为了确定 这些参数之间的关系以及骨的测量 骨矿物质转换（骨钙素和尿钙） 在三个部位（桡骨、脊柱和股骨）测量骨密度（BMD）， BLSA的正常男女 血清25-OHD、1，25（OH）2D和PTH 与年轻（<48岁）男性或老年（>60岁）男性任何部位的BMD无关 妇女 然而，在老年男性中，较低的年龄调整的桡骨BMD是 与较高的PTH和1，25（OH）2 D以及较低的25 OHD显着相关 价值观 年轻男性，股骨BMD横截面下降 与老年人相比， 对于低年龄校正BMD的骨转换标志物。 这些结果 强调了骨丢失的异质性及其相关因素。 这种异质性部分取决于年龄，性别和具体的 骨部位受累。