BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

骨代谢的生化参数——年龄和性别对比

• 批准号: 3745468
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745468
• 关键词: adult human (21+); aging; bone density; bone metabolism; calcium metabolism; female; gender difference; human data; human old age (65+); human very old age (85+); male; muscle strength; sex hormones

Age-related changes in bone mass have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. The relationship of muscle strength, as estimated by concentric torque in the lower extremity, to bone mineral density, was evaluated in 80 men and 73 women ranging from 23 to 88 years of age. These normal volunteers from the Baltimore Longitudinal Study of Ageing had highly significant negative correlations of age with muscle strength and bone mineral density. At the same time muscle strength was positively correlated with estimates of bone mineral density. When the effect of age was analyzed by multiple regression techniques there was no age-independent contribution of muscle strength to bone mineral density in women, but there remained a significant relationship of muscle strength to bone mass in men with stronger men having greater bone mass at any age. This different strength-bone relationship in men and women may indicate a role for anabolic sex hormones in the maintenance of bone mass during aging.

在这两名男性中， 和妇女 年龄和性别相关的差异激素，营养和 参与骨转换的生理变量在 阐明正常衰老和疾病中骨骼生理学的变化。 的 肌肉力量的关系，如通过在 下肢，骨矿物质密度，评价了80名男子和73 年龄在23岁至88岁之间的妇女。 这些正常的志愿者来自 巴尔的摩老龄化纵向研究具有高度显著性， 年龄与肌力、骨矿含量呈负相关 密度的 与此同时，肌肉力量与 骨矿物质密度的估计值。当分析年龄的影响时， 多元回归分析表明， 肌肉力量对女性骨密度的贡献，但 肌肉力量与骨量之间仍有显著关系， 在任何年龄段，强壮的男性都有更大的骨量。 这 男性和女性不同的力量-骨骼关系可能表明 合成代谢性激素在维持骨量中的作用 衰老