NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 9462199
• 负责人: EDWARD F BELL
• 金额: $ 27.6万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9462199
• 关键词: Academic Medical Centers; Address; Agriculture; Area; Cessation of life; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Country; DNA Library; DNA Repository; Disabled Persons; Discipline of obstetrics; Disease; Enrollment; Ensure; Evaluation; Faculty; Fostering; Genetic; Genomic approach; Genomics; Health; Infant; Iowa; Medicine; Mission; Morbidity - disease rate; Multicenter Neonatal Research Network; Multicenter Trials; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care; Neonatology; Neurodevelopmental Impairment; Newborn Infant; Outcome; Patients; Pediatrics; Perinatal; Population; Premature Infant; Productivity; Research; Research Infrastructure; Resources; Role; Rural; Rural Population; Safety; Sampling; Therapeutic; Time; Translations; Universities; Work; base; career development; clinical practice; critically ill newborn; design; follow-up; genetic approach; member; mortality; neonate; novel therapeutics; population based; pressure; programs; prospective; public health relevance; research study; success

 DESCRIPTION (provided by applicant): The University of Iowa submits this renewal application for continued participation in the NICHD Cooperative Multicenter Neonatal Research Network (RFA-HD-16-020). We offer five special strengths to the Network. 1. Our NICU's clinical outcomes are superb - among the best in the world. Our ELBW mortality rate is perennially among the lowest in the Neonatal Research Network, and most years we have the lowest rate of the composite outcome of death or neurodevelopmental impairment. 2. We have a strong tradition and track record of important contributions in clinical research in neonates and infants. In the obstetrics units and the NICU, we have a robust infrastructure for the conduct and support of clinical research that has contributed to our productivity. 3. We have considerable expertise and resources in the area of genetics, including our Perinatal Research DNA Bank, which was created in 1999. Samples from our DNA Bank and others are being used for research on the genetic influences of neonatal disease. During our first 10 years in the Network, members of our team have worked with others in the Network to apply genetics and genomics approaches on a Network-wide scale, including a proposal to develop a prospective DNA repository. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of Iowa Network center represents this region and population. 5. We have performed extremely well as a Network center during the past 5 years. We have contributed 15% (17/114) of the new projects submitted for consideration since we joined the Network. Our ELBW mortality rate is always among the lowest in the Network, which allows us to see a large number of infants in follow-up.

 描述（由申请人提供）：爱荷华州的大学提交继续参与NICHD合作多中心新生儿研究网络（RFA-HD-16-020）的更新申请。我们为网络提供五个特殊优势。 1.我们的新生儿重症监护室的临床结果是一流的-在世界上最好的。在新生儿研究网络中，我们的ELBW死亡率常年处于最低水平，并且大多数年份我们的死亡或神经发育障碍复合结局率最低。 2.我们在新生儿临床研究方面有着悠久的传统和重要贡献的记录， 婴儿。在产科单位和新生儿重症监护室，我们有一个强大的基础设施，进行和支持临床研究，有助于我们的生产力。 3.我们在遗传学领域拥有大量的专业知识和资源，包括我们于1999年创建的围产期研究DNA库。我们的DNA库和其他机构的样本正在用于研究新生儿疾病的遗传影响。在我们进入该网络的头10年里，我们的团队成员与网络中的其他人合作，在全网络范围内应用遗传学和基因组学方法，包括提出一项开发潜在DNA储存库的建议。 4.作为一个主要以农业为基础的经济的农村国家唯一的学术医疗中心，我们代表了一个在NICHD网络中没有很好代表的人口。如果要将网络研究的结果推广到全国各地的患者，则应代表该国的这一大片地区。爱荷华州网络中心的大学代表这一地区和人口。 5.在过去的5年里，我们作为网络中心表现非常出色。自我们加入该网络以来，在提交审议的新项目中，我们贡献了15%（17/114）。我们的极低出生体重儿死亡率一直是该网络中最低的，这使我们能够看到大量的婴儿在后续行动。