NICHD Cooperative Multicenter Neonatal Research Network

 描述(由申请人提供)：爱荷华大学提交续签申请，继续参加NICHD合作多中心新生儿研究网络(RFA-HD-16-020)。我们为该网络提供了五个特别的优势。1.我们的NICU的临床结果是一流的--在世界上名列前茅。我们的ELBW死亡率在新生儿研究网络中一直是最低的，而且大多数年份我们的死亡或神经发育障碍的综合结局的比率都是最低的。2.我们在新生儿和新生儿的临床研究中做出了重要贡献，有着深厚的传统和过往记录 婴儿。在产科和NICU，我们拥有强大的基础设施来进行和支持临床研究，这对我们的生产力做出了贡献。3.我们在遗传学领域拥有相当多的专门知识和资源，包括我们于1999年建立的围产期研究DNA资料库。我们的DNA库和其他机构的样本正被用于研究新生儿疾病的遗传影响。在我们加入网络的头10年里，我们团队的成员与网络中的其他人合作，在网络范围内应用遗传学和基因组学方法，包括开发一个未来的DNA储存库的建议。4.作为一个以农村为主、经济以农业为基础的州唯一的学术医疗中心，我们代表的人口在NICHD网络中没有得到很好的代表。如果网络研究的结果要推广到全国的患者，就应该代表这个国家的这一大片地区。爱荷华大学网络中心代表着这个地区和人口。5.在过去的5年里，我们作为网络中心的表现非常好。自我们加入该网络以来，我们贡献了提交审议的新项目的15%(17/114)。我们的ELBW死亡率一直是该网络中最低的之一，这使我们能够看到大量婴儿在后续行动中。

 DESCRIPTION (provided by applicant): The University of Iowa submits this renewal application for continued participation in the NICHD Cooperative Multicenter Neonatal Research Network (RFA-HD-16-020). We offer five special strengths to the Network. 1. Our NICU's clinical outcomes are superb - among the best in the world. Our ELBW mortality rate is perennially among the lowest in the Neonatal Research Network, and most years we have the lowest rate of the composite outcome of death or neurodevelopmental impairment. 2. We have a strong tradition and track record of important contributions in clinical research in neonates and infants. In the obstetrics units and the NICU, we have a robust infrastructure for the conduct and support of clinical research that has contributed to our productivity. 3. We have considerable expertise and resources in the area of genetics, including our Perinatal Research DNA Bank, which was created in 1999. Samples from our DNA Bank and others are being used for research on the genetic influences of neonatal disease. During our first 10 years in the Network, members of our team have worked with others in the Network to apply genetics and genomics approaches on a Network-wide scale, including a proposal to develop a prospective DNA repository. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of Iowa Network center represents this region and population. 5. We have performed extremely well as a Network center during the past 5 years. We have contributed 15% (17/114) of the new projects submitted for consideration since we joined the Network. Our ELBW mortality rate is always among the lowest in the Network, which allows us to see a large number of infants in follow-up.