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Imaging and Radiochemistry Core

成像和放射化学核心

基本信息

批准号：
9532118
负责人：
PAT B ZANZONICO
金额：
$ 14.45万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9532118
关键词：
Animal Model Animals Binding Biological Blood Brain Neoplasms Cancer Model Chemicals Clinical Computer software Computers Cyclotrons Detection Development Diagnostic Imaging Dose Dyes Equipment Fluorescence Functional Imaging Funding Genetic Engineering Hand High Pressure Liquid Chromatography I125 isotope Image Investigation Iodine Kinetics Label Laboratories Lutetium Magnetic Resonance Imaging Malignant Neoplasms Memorial Sloan-Kettering Cancer Center Methods Miniature Swine Modality Modeling Molecular Mus Nerve Non-Small-Cell Lung Carcinoma Normal tissue morphology Optics Peptides Positron Positron-Emission Tomography Primary Brain Neoplasms Production Property Radiation Radiochemistry Radioisotopes Radiolabeled Radiometry Reagent Research Research Project Grants Research Support Resource Sharing Resources Rodent Running Silicon Dioxide System Tissue Sample Tracer Translations Tumor Tissue Ultrasonography Xenograft procedure base cancer imaging clinically translatable cyanine dye 5 data management dosimetry fluorescence imaging imaging capabilities imaging study imaging system in vivo in vivo Model in vivo imaging system instrumentation melanoma microPET molecular phenotype nanomedicine nanoparticle optical imaging particle particle exposure screening systems research tool tumor urinary

项目摘要

SHARED RESOURCE CORE - IMAGING AND RADIOCHEMISTRY CORE (CORE B) Project Abstract/Summary The research proposed in the MC2TCN is focused on particle-driven, multi-modality translational developments of radiolabeled ultra-small fluorescent core-shell silica nanoparticles for oncologic diagnostic imaging and therapy. In support of this overarching theme, the Imaging and Radiochemistry Core will provide expertise and state-of-the-art instrumentation in positron emission tomography (PET), fluorescence imaging, and cyclotron production of radionuclides. The specific functions, then, of the Core are to provide for the research projects - both using small animal (rodents) and larger animal models (miniswine) - in vivo structural and functional imaging capabilities, related image display, analysis, and data management tools, cyclotron-produced positron- emitting radioisotopes (e.g., iodine-124 (124I) for synthesis of clinical-grade nanoparticle-based molecular tracers, and compartmental modeling-based kinetic analysis and radiation dosimetry software and expertise.

共享资源核心-成像和放射化学核心（核心B）项目摘要/摘要 MC 2 TCN中提出的研究重点是粒子驱动的多模态翻译开发用于肿瘤诊断成像的放射性标记的超小荧光核-壳二氧化硅纳米颗粒，疗法为了支持这一总体主题，成像和放射化学核心将提供专业知识，正电子发射断层扫描（PET）、荧光成像和回旋加速器中最先进的仪器生产放射性核素。因此，核心的具体职能是为研究项目提供经费- 使用小动物（啮齿动物）和较大动物模型（小型猪）-体内结构和功能成像能力，相关的图像显示，分析和数据管理工具，回旋加速器产生的正电子，发射放射性同位素（例如，碘-124（124 I）用于合成临床级纳米颗粒基分子示踪剂和基于房室模型的动力学分析和辐射剂量测定软件和专门知识。