Imaging and Radiochemistry Core

共享资源核心-成像和放射化学核心（核心B） 项目摘要/摘要 MC 2 TCN中提出的研究重点是粒子驱动的多模态翻译开发 用于肿瘤诊断成像的放射性标记的超小荧光核-壳二氧化硅纳米颗粒， 疗法为了支持这一总体主题，成像和放射化学核心将提供专业知识， 正电子发射断层扫描（PET）、荧光成像和回旋加速器中最先进的仪器 生产放射性核素。因此，核心的具体职能是为研究项目提供经费- 使用小动物（啮齿动物）和较大动物模型（小型猪）-体内结构和功能 成像能力，相关的图像显示，分析和数据管理工具，回旋加速器产生的正电子， 发射放射性同位素（例如，碘-124（124 I）用于合成临床级纳米颗粒基分子 示踪剂和基于房室模型的动力学分析和辐射剂量测定软件和专门知识。

SHARED RESOURCE CORE - IMAGING AND RADIOCHEMISTRY CORE (CORE B) Project Abstract/Summary The research proposed in the MC2TCN is focused on particle-driven, multi-modality translational developments of radiolabeled ultra-small fluorescent core-shell silica nanoparticles for oncologic diagnostic imaging and therapy. In support of this overarching theme, the Imaging and Radiochemistry Core will provide expertise and state-of-the-art instrumentation in positron emission tomography (PET), fluorescence imaging, and cyclotron production of radionuclides. The specific functions, then, of the Core are to provide for the research projects - both using small animal (rodents) and larger animal models (miniswine) - in vivo structural and functional imaging capabilities, related image display, analysis, and data management tools, cyclotron-produced positron- emitting radioisotopes (e.g., iodine-124 (124I) for synthesis of clinical-grade nanoparticle-based molecular tracers, and compartmental modeling-based kinetic analysis and radiation dosimetry software and expertise.