Imaging and Radiochemistry Core

成像和放射化学核心

• 批准号: 8961776
• 负责人: PAT B ZANZONICO
• 金额: $ 21.53万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-27 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8961776
• 关键词: Animal Model; Animals; Binding; Biological; Blood; Brain Neoplasms; Cancer Model; Chemicals; Clinical; Computer software; Cyclotrons; Detection; Development; Diagnostic Imaging; Dose; Dyes; Equipment; Fluorescence; Functional Imaging; Funding; Genetic Engineering; Hand; High Pressure Liquid Chromatography; I125 isotope; Image; Investigation; Iodine; Kinetics; Label; Laboratories; Lutetium; Magnetic Resonance Imaging; Malignant Neoplasms; Methods; Miniature Swine; Modality; Modeling; Molecular; Mus; Nerve; Non-Small-Cell Lung Carcinoma; Normal tissue morphology; Optics; Peptides; Positron; Positron-Emission Tomography; Primary Brain Neoplasms; Production; Property; Radiation; Radiochemistry; Radioisotopes; Radiolabeled; Radiometry; Reagent; Research; Research Project Grants; Resource Sharing; Resources; Rodent; Running; Silicon Dioxide; System; Tissue Sample; Tracer; Translations; Ultrasonography; Xenograft procedure; abstracting; base; cancer imaging; data management; dosimetry; fluorescence imaging; imaging system; in vivo; in vivo Model; instrumentation; melanoma; microPET; molecular phenotype; nanomedicine; nanoparticle; optical imaging; particle; radiotracer; screening; systems research; tool; tumor; urinary

SHARED RESOURCE CORE - IMAGING AND RADIOCHEMISTRY CORE (CORE B) Project Abstract/Summary The research proposed in the MC2TCN is focused on particle-driven, multi-modality translational developments of radiolabeled ultra-small fluorescent core-shell silica nanoparticles for oncologic diagnostic imaging and therapy. In support of this overarching theme, the Imaging and Radiochemistry Core will provide expertise and state-of-the-art instrumentation in positron emission tomography (PET), fluorescence imaging, and cyclotron production of radionuclides. The specific functions, then, of the Core are to provide for the research projects - both using small animal (rodents) and larger animal models (miniswine) - in vivo structural and functional imaging capabilities, related image display, analysis, and data management tools, cyclotron-produced positron- emitting radioisotopes (e.g., iodine-124 (124I) for synthesis of clinical-grade nanoparticle-based molecular tracers, and compartmental modeling-based kinetic analysis and radiation dosimetry software and expertise.

共享资源核心--成像和放射化学核心(核心B) 项目摘要/摘要 MC2TCN中提出的研究重点是助词驱动的、多通道的翻译发展 放射性标记的超小荧光核壳二氧化硅纳米粒子用于肿瘤诊断成像和 心理治疗。为支持这一重要主题，成像和放射化学核心将提供专门知识和 正电子发射断层扫描(PET)、荧光成像和回旋加速器的最新仪器 放射性核素的生产。因此，核心的具体职能是为研究项目提供资金- 使用小动物(啮齿动物)和较大动物模型(迷你葡萄酒)--体内结构和功能 成像功能、相关的图像显示、分析和数据管理工具、回旋加速器生产的正电子- 发射放射性同位素(例如，碘-124(124I))以合成临床级纳米颗粒分子 示踪剂，以及基于隔室建模的动力学分析和辐射剂量测定软件和专业知识。