The Inveon PET/CT for Pre-Clinical Oncology Research
用于临床前肿瘤学研究的 Inveon PET/CT
基本信息
- 批准号:8334760
- 负责人:
- 金额:$ 102.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:10 year old8 year oldAnimalsBiodistributionCapitalClinical OncologyCore FacilityDiseaseDockingEmission-Computed TomographyFundingFunding ApplicantImageImmuneMalignant NeoplasmsManufacturer NameMedicalMemorial Sloan-Kettering Cancer CenterModalityModelingMonitorMusPathway interactionsPositronProcessRadiation therapyRadioisotopesRattusResearchResearch InfrastructureResolutionResourcesServicesSolutionsStem cellsSystemTransmission Computed TomographyWidthgene therapyin vivoinstrumentoncologypre-clinicalpre-clinical researchprogramsresponsetraffickingtumor
项目摘要
DESCRIPTION (provided by applicant): Funds are being requested to purchase an Inveon PET (positron emission computed tomography) and dockable CT (transmission computed tomography) scanner (Siemens Medical Solutions USA, Inc, Knoxville, TN) for non-invasively and longitudinally monitoring cancer and other disease processes, trafficking of cancer, immune, and stem cells, cellular responses to therapy and other interventions, genetic pathway expression, and tumor targeting and biodistribution of new radiodiagnostic and radiotherapeutic agents in small-animal (i.e. mouse and rat) models. This state-of-the-art instrument, to be installed in our existing Small- Animal Imaging Core Facility, will be a critical, broadly used resource for the pre-clinical and translational oncology research program at Memorial Sloan-Kettering Cancer Center (MSKCC). The Inveon microPET- microCT (dockable) will replace our R4 microPET and microCAT II microCT. The R4 microPET was installed in 2000 and is now over 10 years old while the microCAT II was installed in 2003 and is now over 8 years old. Importantly, as of June 30, 2011, the R4 microPET is no longer supported, and, as of January 1, 2012, the microCAT II microCT will no longer be supported by the manufacturer, Siemens Medical Solutions USA, because the necessary replacement parts are no longer available for these instruments; this is documented in Section 12. Therefore, should either or both of these instruments require service support and replacement parts, they will simply not be available and these heavily used, critical resources will be immediately and permanently unavailable, a potentially devastating blow to our pre-clinical research program. Funds for a new, fully supported, and more functional microPET-microCT system, the Inveon microPET-microCT (dockable), are therefore urgently requested to maintain, enhance and expand our in vivo radionuclide and radiographic imaging capabilities. In addition to maintaining manufacturer service and applications support, among the critical advantages of the Inveon microPET-microCT (dockable) over our now-outdated R4 microPET and microCAT II microCT are: (1) superior spatial resolution - 1.4 mm full-width half-maximum (FWHM) for PET and 20 ¿m for CT; (2) higher PET sensitivity - > 10%; and (3) the unique ability to use the microPET-microCT as a fully integrated multi-modality system for transparent, near-perfect registration of PET and CT studies or as stand-alone microPET and microCT systems for independent imaging of separate animals. This docking feature eliminates the capital and operating expenses for a separate CT scanner. In addition to numerous new and ongoing funded projects in place to use the Inveon microPET-microCT (dockable), our Facility and our Center have well-established technical and scientific expertise to continue to fully and productively utilize this instrument upon its installtion and a highly efficient administrative and financial infrastructure in place to support and maintain
this instrument and its effective use long-term.
描述(申请人提供):正在申请资金购买一个Inveon PET(正电子发射计算机断层扫描)和可对接CT(透射式计算机断层摄影)扫描仪(Siemens Medical Solutions USA,Inc,诺克斯维尔,田纳西州),用于非侵入性和纵向监测癌症和其他疾病过程,癌症、免疫和干细胞的运输,对治疗和其他干预的细胞应答,遗传途径表达,以及新的放射诊断剂和放射治疗剂在小动物(即小鼠和大鼠)模型中的肿瘤靶向和生物分布。这种最先进的仪器将安装在我们现有的小动物成像核心设施中,将成为纪念斯隆-凯特琳癌症中心(MSKCC)临床前和转化肿瘤学研究项目的关键、广泛使用的资源。Inveon microPET- microCT(可对接)将取代我们的R4 microPET和microCAT II microCT。R4 microPET安装于2000年,现已超过10年,而microCAT II安装于2003年,现已超过8年。重要的是,自2011年6月30日起,不再支持R4 microPET,自2012年1月1日起,制造商Siemens Medical Solutions USA将不再支持microCAT II microCT,因为这些仪器不再提供必要的更换部件;这在第12节中记录。因此,如果这两种仪器中的一种或两种需要服务支持和更换部件,它们将根本不可用,这些大量使用的关键资源将立即永久不可用,这对我们的临床前研究计划可能是毁灭性的打击。因此,迫切需要为一个新的、得到充分支持的、功能更强的microPET-microCT系统-Inveon microPET-microCT(可对接)-提供资金,以维持、加强和扩大我们的体内放射性核素和放射成像能力。除了维护制造商服务和应用程序支持外,Inveon microPET-microCT的关键优势之一是与我们现在过时的R4 microPET和microCAT II microCT相比,(可对接):(1)上级空间分辨率-PET为1.4 mm半高宽(FWHM),CT为20 μ m;(2)更高的PET灵敏度- > 10%;以及(3)将microPET-microCT用作完全集成的多模态系统以实现PET和CT研究的透明、近乎完美的配准或用作独立的microPET和microCT系统以实现单独动物的独立成像的独特能力。这种对接功能消除了单独CT扫描仪的资本和运营费用。除了许多新的和正在进行的资助项目,以使用Inveon microPET-microCT(可对接),我们的设施和我们的中心有完善的技术和科学专业知识,继续充分和富有成效地利用这一仪器安装和高效的行政和财务基础设施到位,以支持和维护
这一工具及其长期有效使用。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Radiobiology in Cardiovascular Imaging.
心血管成像中的放射生物学。
- DOI:10.1016/j.jcmg.2016.09.012
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Zanzonico,Pat;Dauer,Lawrence;Strauss,HWilliam
- 通讯作者:Strauss,HWilliam
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PAT B ZANZONICO其他文献
PAT B ZANZONICO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PAT B ZANZONICO', 18)}}的其他基金
The X-Rad SmART+ Biological Irradiator for Pre-Clinical Oncology Research
用于临床前肿瘤学研究的 X-Rad SmART 生物辐照器
- 批准号:
10175157 - 财政年份:2021
- 资助金额:
$ 102.78万 - 项目类别:
The Ivis Spectrum CT for Pre-Clinical Oncology Research
用于临床前肿瘤学研究的 Ivis Spectrum CT
- 批准号:
8446658 - 财政年份:2013
- 资助金额:
$ 102.78万 - 项目类别:
相似海外基金
Neurolinguistic development in 4 to 8 year-old late talkers with language delay
语言迟缓的 4 至 8 岁说话晚者的神经语言发育
- 批准号:
10539603 - 财政年份:2023
- 资助金额:
$ 102.78万 - 项目类别:
The effect of in-utero exposure to metformin in 5-8 year old offspring of mothers in the MiTy Trial (MiTy Tykes)
MiTy 试验 (MiTy Tykes) 中子宫内暴露于二甲双胍对母亲 5-8 岁后代的影响
- 批准号:
432867 - 财政年份:2020
- 资助金额:
$ 102.78万 - 项目类别:
Operating Grants
Bone strength in 8 year old children: influence of preg nancy, early childhood and current lifestyle factor
8 岁儿童的骨强度:怀孕、幼儿期和当前生活方式因素的影响
- 批准号:
nhmrc : 961030 - 财政年份:1996
- 资助金额:
$ 102.78万 - 项目类别:
NHMRC Project Grants