Greater Southern California Node of the Clinical Trials Network

临床试验网络大南加州节点

• 批准号: 10359088
• 负责人: YIH-ING HSER
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10359088
• 关键词: Address; Area; Behavior Therapy; California; Cellular Phone; Clinical Research; Clinical Treatment; Clinical Trials Network; Collaborations; Concept Review; Data Science; Development; Drug abuse; Electronic Health Record; Faculty; Generations; Goals; Health; Health Care Research; Health Services Accessibility; Health care facility; Healthcare; Helping to End Addiction Long-term; Improve Access; Individual; Interdisciplinary Study; Intervention; Intervention Studies; Journals; Lead; Leadership; Mission; Modeling; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; New York; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Population; Population Heterogeneity; Principal Investigator; Protocols documentation; Public Health; Research; Research Infrastructure; Research Personnel; Research Priority; Research Support; Seminal; Substance Use Disorder; System; Talents; Technology; Telemedicine; Testing; Training; Treatment Effectiveness; Treatment outcome; United States; United States National Institutes of Health; Vulnerable Populations; Work; base; clinical practice; clinical trial implementation; comorbidity; design; eHealth; health care service organization; health care settings; implementation science; implementation strategy; improved; improved outcome; innovation; innovative technologies; mHealth; meetings; mortality; opioid epidemic; opioid use disorder; overdose death; protocol development; response; rural area; rural setting; service delivery; student training; substance use treatment; treatment services; uptake

Project Summary/Abstract The overarching goal of the Greater Southern California Node (GSCN) of the National Drug Abuse Treatment Clinical Trials Network (CTN) is to expand access to and improve outcomes of treatments for substance use disorders (SUDs)—with a special emphasis on opioid use disorder (OUD) —by collaboratively developing and testing effective and sustainable interventions for OUD that can be delivered in diverse healthcare settings. To achieve this goal, we have assembled (1) local, regional, and state-wide healthcare networks that serve millions of individuals, (2) investigators who have conducted seminal work on development and testing of pharmacological and behavioral interventions for SUDs, and (3) researchers with expertise in implementation strategies, data science, and innovative technologies to support treatment delivery and related research. Building upon investigators' past and current efforts, the specific aims of GSCN are: Aim 1. Lead and contribute to the development of new research protocols designed to increase access to treatments for OUD and to improve treatment outcomes; Aim 2. Support and participate in multi-site CTN projects and other CTN activities; and Aim 3. Disseminate research findings and provide innovative training to impact clinical practice. The GSCN research agenda will initially focus on four priority areas: (1) developing and testing effective medication and behavioral interventions for OUD and related comorbidities, (2) applying implementation science to deliver and expand OUD treatment in multiple healthcare settings, (3) leveraging eHealth (e.g., electronic health record systems) and data science for discovery and generation of innovative hypotheses and approaches to improve treatment for OUD, and (4) building on mHealth (e.g., smartphone- assisted interventions) and other technologies (e.g., telemedicine) to expand OUD treatment access and utilization. The GSCN research agenda reflects its capacity to collaboratively expand CTN efforts to develop and implement innovative approaches to improve treatment for OUD and other SUDs.

项目概要/摘要 国家药物滥用大南加州节点 (GSCN) 的总体目标 治疗临床试验网络 (CTN) 旨在扩大治疗的可及性并改善其结果 物质使用障碍（SUD）——特别强调阿片类药物使用障碍（OUD）——通过合作 开发和测试有效且可持续的 OUD 干预措施，这些干预措施可以通过多种方式提供 医疗保健设置。为了实现这一目标，我们聚集了 (1) 地方、区域和全州范围的医疗保健 为数百万人服务的网络，(2) 在发展方面开展开创性工作的调查人员 SUD 的药理学和行为干预措施的测试，以及 (3) 具有以下专业知识的研究人员 支持治疗提供和相关的实施战略、数据科学和创新技术 研究。基于调查人员过去和当前的努力，GSCN 的具体目标是： 目标 1. 领导 并致力于制定新的研究方案，旨在增加获得治疗的机会 OUD 并改善治疗结果；目标2.支持和参与多站点CTN项目和其他 CTN活动；目标 3. 传播研究成果并提供创新培训以影响临床 实践。 GSCN 研究议程最初将重点关注四个优先领域：(1) 开发和测试 针对 OUD 和相关合并症的有效药物和行为干预，(2) 应用 实施科学在多个医疗保健环境中提供和扩展 OUD 治疗，(3) 利用 电子医疗（例如电子健康记录系统）和数据科学，用于发现和产生创新 改善 OUD 治疗的假设和方法，以及 (4) 基于移动医疗（例如智能手机） 辅助干预）和其他技术（例如远程医疗），以扩大 OUD 治疗的可及性和 利用率。 GSCN 研究议程反映了其协作扩展 CTN 开发工作的能力 并实施创新方法来改善 OUD 和其他 SUD 的治疗。