Electrical and Ultrasonic Modulation of Lateral Cerebellar Nucleus
Electrical and Ultrasonic Modulation of Lateral Cerebellar Nucleus
批准号:
10347883
负责人:
MESUT SAHIN
金额:
$21.73万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-30 至 2023-08-31
关键词:
AddressAffectAnatomyAnimal ModelAreaAxonBasal GangliaBrainCell NucleusCellsCerebellar CortexCerebellar DiseasesCerebellar NucleiCerebellumClinicalClinical ResearchClinical TrialsCognitionCognitiveCollaborationsDeep Brain StimulationDiseaseElectric StimulationElectrodesEmotionalEmotionsEquipmentFocused UltrasoundFunctional ImagingGoalsImageInstitutesLateralLeadLettersMental disordersMethodologyMethodsModalityMotivationMotorNeuronsNeurosciencesNorth CarolinaOperative Surgical ProceduresOutputPathway interactionsPatientsPenetrationPhasePopulationProcessProsencephalonProtocols documentationPurkinje CellsRattusReportingResearchRiskRoleSourceStimulusStructureTechnologyThalamic structureTherapeuticTissuesUltrasonicsUltrasonographyUniversitiesanimal dataclinical applicationcrystallinityexperimental studyimplantationimprovedknowledge basemotor learningnervous system disorderneural circuitneuroregulationnoninvasive brain stimulationnoveloptogeneticspsychiatric symptomtool
中文摘要
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英文摘要
Electrical and Ultrasonic Modulation of Lateral Cerebellar Nucleus
Abstract
The cerebellum has been overlooked for its potential for neuromodulation for decades. Traditionally
thought of as critical for motor coordination, anatomical, clinical and imaging evidence now indicate that the
cerebellum also has central roles in cognition and emotion, and that cerebellar dysfunction impacts these
functions. Consistent with these findings of cerebellar involvement in motor and non-motor functions,
projections from the cerebellar nuclei (CN) target, via the thalamus, both motor and non-motor areas of the
cortex and the basal ganglia. Thus, modulation of cerebellar outputs should be able to affect areas throughout
the forebrain, and therefore has the potential to treat numerous disorders.
Gap in Prior Research: Stimulation of the cerebellar cortex produced mixed results in clinical trials, almost
fifty years ago, and discouraged further attempts. Whereas stimulation of the CN, where the efferent axons
from the cerebellar cortex converge, has recently been shown to have clinical benefits in patients and animal
models. However, direct stimulation of the CN requires surgical implantation of deep brain stimulation leads
into the cerebellum.
Novel Solution by Current Technology: Focused Ultrasound (FUS) Stimulation and Transcranial Electrical
Stimulation (tES) are two non-invasive brain stimulation methods that have great potentials for clinical
applications and provide ideal tools for cerebellar stimulation. FUS has the potential to stimulate the CN
directly with its superior focusing and steering capabilities. tES would be the preferred method for stimulation of
the cerebellar cortex due to its ease of application and the inexpensive equipment involved. Cerebellar
stimulation with ultrasound has not been reported by any other group to date and tES for the cerebellum is
severely lacking animal data for understanding of underlying mechanisms. Advances in the past two decades
on functional imaging and anatomical mapping provide an improved understanding of the circuitry of the
cerebellar cortex and its connections to the cerebellar nuclei. Thus, we have novel tools and the knowledge
base to develop protocols for effective modulation of the cerebellar outputs.
Current Proposal: The overarching goal of this proposal is to develop a non-invasive and effective modulation
paradigm for one of the cerebellar nuclei, the lateral cerebellar nucleus (LCN). Optimal stimulation parameters
will be investigated for selective stimulation of neuronal subtypes in the LCN. Novel mechanisms of
neuromodulation will be investigated that can emerge from combined application of the electrical and ultrasonic
methods. The modulation paradigms developed in this project should generalize to numerous motor and non-
motor brain functions in which the cerebellum is involved.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.brs.2021.03.004
发表时间:
2021-05
期刊:
Brain stimulation
影响因子:
7.7
作者:
[Asan AS, Kang Q, Oralkan Ö, Sahin M]
通讯作者:
Sahin M
DOI:
10.3389/fnins.2023.1282322
发表时间:
2023
期刊:
FRONTIERS IN NEUROSCIENCE
影响因子:
4.3
作者:
[Kang, Qi, Lang, Eric J., Sahin, Mesut]
通讯作者:
Sahin, Mesut
Spinal Cord-to-Computer Interface
-
批准号:8522320
-
项目类别:
-
资助金额:$27.27万
-
财政年份:2011
-
负责人:MESUT SAHIN
-
依托单位:
Spinal Cord-to-Computer Interface
-
批准号:8720825
-
项目类别:
-
资助金额:$27.86万
-
财政年份:2011
-
负责人:MESUT SAHIN
-
依托单位:
Spinal Cord-to-Computer Interface
-
批准号:8328925
-
项目类别:
-
资助金额:$28.36万
-
财政年份:2011
-
负责人:MESUT SAHIN
-
依托单位:
Spinal Cord-to-Computer Interface
-
批准号:8187094
-
项目类别:
-
资助金额:$28.17万
-
财政年份:2011
-
负责人:MESUT SAHIN
-
依托单位:
Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
-
批准号:8089484
-
项目类别:
-
资助金额:$32.52万
-
财政年份:2009
-
负责人:MESUT SAHIN
-
依托单位:
Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
-
批准号:7741496
-
项目类别:
-
资助金额:$34.88万
-
财政年份:2009
-
负责人:MESUT SAHIN
-
依托单位:
Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
-
批准号:8281535
-
项目类别:
-
资助金额:$32.43万
-
财政年份:2009
-
负责人:MESUT SAHIN
-
依托单位:
Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
-
批准号:7900403
-
项目类别:
-
资助金额:$34.19万
-
财政年份:2009
-
负责人:MESUT SAHIN
-
依托单位:
Spinal Cord Computer Interface
-
批准号:7405397
-
项目类别:
-
资助金额:$18.16万
-
财政年份:2007
-
负责人:MESUT SAHIN
-
依托单位:
Spinal Cord Computer Interface
-
批准号:7255246
-
项目类别:
-
资助金额:$21.41万
-
财政年份:2007
-
负责人:MESUT SAHIN
-
依托单位:
Floating Micro-Stimulators for Neural Prosthetics
-
批准号:7140507
-
项目类别:
-
资助金额:$14.76万
-
财政年份:2005
-
负责人:MESUT SAHIN
-
依托单位:
Floating Micro-Stimulators for Neural Prosthetics
-
批准号:6983078
-
项目类别:
-
资助金额:$16.07万
-
财政年份:2005
-
负责人:MESUT SAHIN
-
依托单位:
海外基金