GH16-006: Conducting Communicable Disease Research in Kenya

项目摘要 华盛顿州立大学(WSU)提议在肯尼亚进行研究，以解决组成部分中的7个目标 A，传染病，RFA-GH-16-006。这项研究分为三个项目，分别是 共同处理以下目标：项目1(1)发展、维持和扩大监测 结合基于人口和基于设施的人口、发病率和死亡率的系统 监测；(2)发展实验室能力和平台，以进行病原学调查和评估 新诊断；项目2(III)进行研究，以评估疾病负担、风险因素和 预防人畜共患感染；(4)开展抗菌素耐药性监测和研究；(5) 开展虫媒病毒及其媒介的流行病学和生态学研究；以及项目3(Vi) 开展与传染病有关的知识、态度和行为的社会文化研究 接受预防方法；(Vii)制定疾病成本和干预估算。至 为了实现这些目标，西澳州立大学组建了一支由20名来自西澳州立大学的科学家组成的团队， 内罗毕大学(UON)、埃默里大学、肯尼亚医学研究所(KEMRI)，堪萨斯州 州立大学和肯尼亚政府。此外，我们还争取到了基础设施支持 KEMRI、UON和亨利·杰克逊基金会的。自2001年以来，疾控中心一直在管理人类 人口监测系统，农村和城市人口为基础的传染病监测 肯尼亚。这些平台和支持实验室旨在帮助确定 在疾病负担和进行疾病干预试验方面也是如此。在这里，西德克萨斯州立大学建议从 按现状管理这些平台，但也要试验新的方法，以促进其财政可持续性。 通过平台和其他监测方法，WSU将调查负担和风险 地方病和新发疾病的因素与抗菌素耐药性。此外，我们还将进行 干预研究，以应对威胁，并与肯尼亚政府分享数据和 倡导政策变革。社会科学家将与疾病研究团队合作，评估 对疾病的看法和治疗选择，以及可能影响人与人之间的行为和 动物与人类之间的传播。评估疾病的经济负担和成本效益 将考虑干预措施的直接和间接影响。这个项目的结果将是 更好地了解这些威胁的级别，并制定干预措施，从而 改善肯尼亚人的健康，减少全球健康威胁。

Project Summary Washington State University (WSU) proposes research in Kenya to address 7 objectives in Component A, Communicable Disease, of RFA-GH-16-006. The research is organized into three projects that together address the following objectives: Project 1 (i) develop, maintain and expand surveillance systems combining population-based and facility-based demographic, morbidity and mortality surveillance; (ii) develop laboratory capacity and platforms for etiologic investigation and evaluation of novel diagnostic; Project 2 (iii) conduct studies to assess the disease burden, risk factors, and prevention of zoonotic infections; (iv) conduct surveillance and research on antimicrobial resistance; (v) conduct research on the epidemiology and ecology of arboviruses and their vectors; and Project 3 (vi) conduct socio-cultural research on knowledge, attitudes and practice related to infectious disease and acceptance of prevention methods; (vii) develop cost of disease and intervention estimates. To accomplish these objectives, WSU has assembled a team of 20 scientists derived from WSU, University of Nairobi (UON), Emory University, Kenya Medical Research Institute (KEMRI), Kansas State University, and the government of Kenya. In addition, we have enlisted the infrastructural support of KEMRI, UON, and Henry Jackson Foundation. Since 2001, CDC has managed the human demographic surveillance system, rural and urban population-based infectious disease surveillance in Kenya. These platforms and the supporting laboratories were designed to assist in determining the burden of diseases and in conducting disease intervention trials. Here, WSU proposes to start by managing the platforms as-is, but also pilot new approaches to promote their fiscal sustainability. Through the platforms and other surveillance approaches, WSU will investigate the burden and risk factors of endemic and emerging diseases and antimicrobial resistance. In addition, we will conduct intervention studies to address the threats, and engage the government of Kenya to share data and advocate for policy change. Social scientists will work with the disease research team to assess the perceptions of diseases and treatment options, as well as behaviors that may affect human-human and animal-human transmission. To assess the economic burden of disease and cost-effectiveness of interventions, both direct and indirect impacts will be considered. The outcome of this project will be better understanding of level of these threats, and development of interventions that result in improvement of the health of Kenyans and reduction in global health threats.