Elucidating Cell Communication Networks during Tissue Inflammation, Fibrosis, and Regeneration

阐明组织炎症、纤维化和再生过程中的细胞通信网络

• 批准号: 9562695
• 负责人: Kevin R King
• 金额: $ 235.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9562695
• 关键词: Cell Communication; Cells; Cicatrix; Clinical; Cognition; Data Analyses; Disease; Fibrosis; Genetic; Grant; Heart; Human body; Image; Inflammation; Injury; Kidney Failure; Liver Failure; Lung; Malignant neoplasm of liver; Molecular; Mus; Myocardial Infarction; Natural regeneration; Neurons; Reporter; Sterility; Stroke; Techniques; Tissues; brain cell; cell type; healing; intravital microscopy; programs; single cell analysis; single cell technology; tissue regeneration; tissue repair; tool

Abstract: Interconnected cells of the brain are the physical basis for cognition; however, electrically excitable neurons represent less than 1% of all cells in the human body. In this DP2 proposal we ask about the remaining cells. Are the vast number of non-excitable cells in the body also interconnected in similarly productive yet undiscovered cell communication networks? If so, what are their emergent functions? We propose an ambitious program that combines technologies of single cell analysis, genetic reporters, intravital microscopy, and quantitative data analysis to systematically discover cell communication networks in living tissue. We will apply these tools and techniques to the study of sterile injury and inflammation in the heart, liver, and cancer in the hopes of better understanding why some tissues fibrose and scar while others heal and regenerate.

摘要： 大脑中相互连接的细胞是认知的物理基础；然而，电兴奋的神经元 只占人体所有细胞的不到1%。在这个DP2提案中，我们询问剩余的单元格。 体内大量不可兴奋的细胞是否也相互联系在一起，产生同样多的能量 未被发现的蜂窝通信网络？如果是这样的话，它们的紧急功能是什么？我们提出了一个雄心勃勃的计划 该项目结合了单细胞分析、遗传记者、活体显微镜和 定量数据分析，系统地发现活组织中的细胞通讯网络。我们会申请 这些工具和技术用于研究心脏、肝脏和癌症的无菌损伤和炎症 希望更好地了解为什么有些组织会纤维和疤痕，而另一些组织会愈合和再生。